| Interacting proteins: Q8N5C8 and O43318 |
Pubmed |
SVM Score :0.0 |
| We have identified a new binding partner of the TGFbeta ( transforming growth factor beta ) activated protein kinase ( TAK 1 ) , termed TAB 3 ( TAK 1 binding protein 3 ) , which shares 48 % amino acid sequence identity with TAB 2 . ^^^ |
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| Interacting proteins: Q8N5C8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Gene profiling during neural induction in Xenopus laevis : regulation of BMP signaling by post transcriptional mechanisms and TAB 3 , a novel TAK 1 binding protein . ^^^ Based on these studies , we propose a role for post transcriptional control of gene expression during neural induction in vertebrates and present a model whereby sustained BMP inhibition is promoted partly through the regulation of TGFbeta activated kinase ( TAK 1 ) activity by a novel TAK 1 binding protein ( TAB 3 ) . . ^^^ |
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| Interacting proteins: Q8N5C8 and O43318 |
Pubmed |
SVM Score :0.0 |
| Here we report the identification and characterization of a novel protein designated TAB 3 , a TAB 2 like molecule that associates with TAK 1 and can activate NF kappaB similar to TAB 2 . ^^^ Cotransfection of siRNAs directed against both TAB 2 and TAB 3 inhibit both IL 1 and TNF induced activation of TAK 1 and NF kappaB . ^^^ These results suggest that TAB 2 and TAB 3 function redundantly as mediators of TAK 1 activation in IL 1 and TNF signal transduction . . ^^^ |
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| Interacting proteins: Q8N5C8 and O43318 |
Pubmed |
SVM Score :0.0 |
| The activation of NF kappaB and IKK requires an upstream kinase complex consisting of TAK 1 and adaptor proteins such as TAB 1 , TAB 2 , or TAB 3 . ^^^ Mutations of the ZnF domain abolish the ability of TAB 2 and TAB 3 to bind polyubiquitin chains , as well as their ability to activate TAK 1 and IKK . ^^^ Significantly , replacement of the ZnF domain with a heterologous ubiquitin binding domain restored the ability of TAB 2 and TAB 3 to activate TAK 1 and IKK . ^^^ |
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