| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.73192339 |
| We recently reported that the overexpression of transforming growth factor beta activated kinase 1 ( TAK 1 ) , a member of the mitogen activated protein kinase kinase kinase family , together with its activator TAK 1 binding protein 1 ( TAB 1 ) stimulates NF kappaB activation . 0.73192339^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.84082204 |
| Furthermore , TAK 1 is constitutively phosphorylated when ectopically overexpressed with TAB 1 . 0.84082204^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.82460928 |
| Expression of the MAP kinase kinase kinase ( MAPKKK ) TAK 1 together with its coactivator TAB 1 in HeLa cells activated all three pathways and was sufficient to induce IL 8 formation , NF kappaB + JNK 2 mediated transcription from a minimal IL 8 promoter , and p 38 MAPK mediated stabilization of a reporter mRNA containing IL 8 derived regulatory mRNA sequences . 0.82460928^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.55064313 |
| One comprises TAK 1 complexed with TAB 1 and TAB 2 , and the other TAK 1 complexed with TAB 1 and TAB 3 . 0.55064313^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Overexpression of TAK 1 together with its activator protein , TAK 1 binding protein 1 ( TAB 1 ) , induced the nuclear translocation of NF kappa B p50 / p65 heterodimer accompanied by the degradation of 1 kappa B alpha and 1 kappa B beta , and the expression of kappa B dependent reporter gene . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| H . pylori LPS stimulated phosphorylation of transforming growth factor beta activated kinase 1 ( TAK 1 ) , TAK 1 binding protein 1 ( TAB 1 ) , and c Jun NH ( 2 ) terminal kinase ( JNK ) 2 . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| These cells expressed the Toll like receptor 4 ( TLR 4 ) mRNA and its protein , and type 1 Hp LPS phosphorylated transforming growth factor beta activated kinase 1 ( TAK 1 ) and TAK 1 binding protein 1 ( TAB 1 ) in association with up regulation of the TLR 4 expressions , suggesting that type 1 Hp LPS evoked distinct TLR 4 signaling . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Moreover , the overexpression of TAK 1 along with TAK 1 binding protein 1 ( TAB 1 ) , or NIK stimulated the transcriptional activation of RANTES in the absence of external stimuli . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAK 1 mitogen activated protein kinase kinase kinase ( MAP3K ) is activated by its specific activator , TAK 1 binding protein 1 ( TAB 1 ) . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Recently , serine / threonine kinase TAK 1 and TAK 1 binding protein 1 and 2 ( TAB1 / 2 ) have been identified as molecules involved in IL 1 induced TRAF 6 mediated activation of AP 1 and NF kappa B via mitogen activated protein ( MAP ) kinases and 1 kappa B kinases , respectively . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Based on the finding that TAB 1 ( TAK 1 binding protein 1 ) binding to TAK 1 is required for TAK 1 activation , a minimal portion of TAK 1 lacking kinase activity that binds to TAB 1 was designed as a TAK 1 dominant negative inhibitor ( TAK 1 DN ) . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Transfection of C 6 glia , primary astrocytes and a rat microglial cell line with TAK 1 ( but not its inactive form ) along with its activator protein , TAK 1 binding protein 1 ( TAB 1 ) resulted in a marked stimulation of a co transfected rat iNOS promoter reporter construct ( iNOS Luc ) . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Ecabet completely blocked the LPS triggered phosphorylation of transforming growth factor beta activated kinase 1 ( TAK 1 ) and TAK 1 binding protein 1 , activation of caspase 8 , loss of mitochondrial membrane potential , release of cytochrome c , activation of caspase 3 , and appearance of apoptotic cells . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAK 1 is known to rely upon an additional protein , TAK 1 binding protein 1 ( TAB 1 ) , for complete activation . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Costimulation of Jurkat cells with 12 O tetradecanoylphorbol 13 acetate and A 23187 leads to a rapid phosphorylation of TAK 1 and TAK 1 binding protein 1 ( TAB 1 ) , critical for TAK 1 activation . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAK 1 binding protein 1 is a pseudophosphatase . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| TGF beta activated kinase 1 binding protein 1 ( TAB 1 ) was identified as a molecule that activates TGF beta activated kinase 1 ( TAK 1 ) . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAB 1 : an activator of the TAK 1 MAPKKK in TGF beta signal transduction . ^^^ The yeast two hybrid system has now revealed two human proteins , termed TAB 1 and TAB 2 ( for TAK 1 binding protein ) , that interact with TAK 1 . ^^^ TAB 1 and TAK 1 were co immunoprecipitated from mammalian cells . ^^^ Overproduction of TAB 1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter , which is regulated by TGF beta , and increased the kinase activity of TAK 1 . ^^^ TAB 1 may function as an activator of the TAK 1 MAPKKK in TGF beta signal transduction . . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Role of TAK 1 and TAB 1 in BMP signaling in early Xenopus development . ^^^ TAK 1 and TAB 1 were identified as a MAPKKK and its activator , respectively , which might be involved in the up regulation of TGF beta superfamily induced gene expression , but their biological role is poorly understood . ^^^ Here , we have examined the role of TAK 1 and TAB 1 in the dorsoventral patterning of early Xenopus embryos . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAK 1 , a member of the MAP kinase kinase kinase family , and its activator , TAB 1 , participate in the bone morphogenetic protein ( BMP ) signaling pathway involved in mesoderm induction and patterning in early Xenopus embryos . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation dependent activation of TAK 1 mitogen activated protein kinase kinase kinase by TAB 1 . ^^^ Here , we characterized the molecular mechanisms of TAK 1 activation by its specific activator TAB 1 . ^^^ Association with TAK 1 and induction of TAK 1 autophosphorylation required the C terminal 24 amino acids of TAB 1 , but full TAK 1 activation required additional C terminal Ser / Thr rich sequences . ^^^ These results demonstrated that the association between the kinase domain of TAK 1 and the C terminal TAB 1 triggered the phosphorylation dependent TAK 1 activation mechanism . . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| An evolutionarily conserved motif in the TAB 1 C terminal region is necessary for interaction with and activation of TAK 1 MAPKKK . ^^^ TAK 1 kinase activity is specifically activated by the TAK 1 binding protein TAB 1 . ^^^ The C terminal 68 amino acid sequence of TAB 1 ( TAB 1 C68 ) is sufficient for TAK 1 interaction and activation . ^^^ Analysis of various truncated versions of TAB 1 C68 defined a C terminal 30 amino acid sequence ( TAB 1 C30 ) necessary for TAK 1 binding and activation . ^^^ We identified a conserved sequence motif , PYVDXA / TXF , in the C terminal domain of mammalian TAB 1 , Xenopus TAB 1 , and its Caenorhabditis elegans homolog TAP 1 , suggesting that this motif constitutes a specific TAK 1 docking site . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Here we report the purification and identification of TRIKA 2 , which is composed of TAK 1 , TAB 1 and TAB 2 , a protein kinase complex previously implicated in IKK activation through an unknown mechanism . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| The goal of this study was to understand how IRAK activates the intermediate proteins TRAF 6 , TAK 1 , TAB 1 , and TAB 2 . ^^^ The translocation of TAB 2 and TRAF 6 is needed to form a TRAF 6 TAK1 TAB 1 TAB2 complex in the cytosol and thus activate TAK 1 . ^^^ Our results show that IRAK is required for the IL 1 induced phosphorylation of TAK 1 , TAB 1 , and TAB 2 . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| In addition to IRAK , we implicate two other components in IL 18 signaling , TAK 1 ( TGF beta activated kinase 1 ) and its activator and substrate TAB 1 . ^^^ A dominant negative mutant of TAK 1 inhibits the IL 18 mediated NFkappaB activation , while IL 18 stimulation leads to the phosphorylation of TAB 1 . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Rather it depends on interaction of p38alpha with TAB 1 [ transforming growth factor beta activated protein kinase 1 ( TAK 1 ) binding protein 1 ] leading to autophosphorylation and activation of p38alpha . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| IRAK then brings TRAF 6 to TAK 1 , TAB 1 , and TAB 2 , which are preassociated on the membrane before stimulation to form the membrane associated complex 2 . ^^^ The formation of complex 2 leads to the phosphorylation of TAK 1 and TAB 2 on the membrane by an unknown kinase , followed by the dissociation of TRAF 6 TAK1 TAB 1 TAB2 ( complex 3 ) from IRAK and consequent translocation of complex 3 to the cytosol . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAB1beta ( transforming growth factor beta activated protein kinase 1 binding protein 1beta ) , a novel splicing variant of TAB 1 that interacts with p38alpha but not TAK 1 . ^^^ Different from TAB 1 , TAB1beta does not bind or activate TAK 1 . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Furthermore , activation of p 38 kinase by overexpression of TAK 1 and TAB 1 , without affecting PPARgamma expression , led the up regulation of transcriptional activity of PPARgamma . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Moreover , Cot induced interleukin 8 production in HeLa cells is almost completely inhibited by the concurrent expression of hKSR 2 , whereas transforming growth factor beta activated kinase 1 ( TAK 1 ) / TAK1 binding protein 1 ( TAB 1 ) induced interleukin 8 production is not affected by hKSR 2 co expression . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAB 1 , a subunit of the kinase TAK 1 , was phosphorylated by SAPK2a / p38alpha at Ser 423 , Thr 431 and Ser 438 in vitro . ^^^ Our results suggest that TAB 1 participates in a SAPK2a / p38alpha mediated feedback control of TAK 1 , which not only limits the activation of SAPK2a / p38alpha but synchronizes its activity with other signalling pathways that lie downstream of TAK 1 ( JNK and IKK ) . . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| In contrast , two TAK 1 binding proteins , TAB 1 and TAB 2 , which are involved in the activation of TAK 1 , were localized in the neurites and the nuclei of the differentiating cells , respectively . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| The activation of NF kappaB and IKK requires an upstream kinase complex consisting of TAK 1 and adaptor proteins such as TAB 1 , TAB 2 , or TAB 3 . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Critical roles of threonine 187 phosphorylation in cellular stress induced rapid and transient activation of transforming growth factor beta activated kinase 1 ( TAK 1 ) in a signaling complex containing TAK 1 binding protein TAB 1 and TAB 2 . ^^^ RNA interference and overexpression experiments demonstrated that TAK 1 binding protein TAB 1 and TAB 2 were involved in the phosphorylation of TAK 1 , but they regulated TAK 1 phosphorylation differentially . ^^^ These results indicate critical roles of Thr 187 phosphorylation in the stress induced rapid and transient activation of TAK 1 in a signaling complex containing TAB 1 and TAB2 . . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Both factors activated endogenous TAK 1 and its activating protein , TAB 1 , and the collagen response was inhibited by dominant negative TAK1a . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAK 1 , but not TAB 1 or TAB 2 , plays an essential role in multiple signaling pathways in vivo . ^^^ Although in vitro biochemical studies have revealed the existence of a TAK 1 complex , which includes TAK 1 and the adapter proteins TAB 1 and TAB 2 , it remains unclear which members of this complex are essential for signaling . ^^^ Using embryonic fibroblasts lacking TAK 1 , TAB 1 , or TAB 2 , we have found that TNFR 1 , IL 1R , TLR 3 , and TLR 4 mediated NF kappaB and AP 1 activation are severely impaired in Tak 1 ( m / m ) cells , but they are normal in Tab 1 ( / ) and Tab 2 ( / ) cells . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Although TAK 1 MEKK3 interaction is not affected by overexpressed TAB 1 , TAB 1 is required for TAK 1 activation and subsequent MEKK 3 phosphorylation . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Activation of TAK 1 in mammals is mediated by two TAK 1 binding proteins , TAB 1 and TAB 2 , but the role of the TAB proteins in the immune response of Drosophila has not yet been established . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Activation of endogenous TAK 1 , a mitogen activated protein kinase ( MAP3K ) regulating the JNK and p 38 MAPK pathways , was induced rapidly by TNF alpha , and co transfection of TAK 1 with its activator protein TAB 1 stimulated activation of JNK and p 38 MAPKs , which led to activation of the transcription factor AP 1 . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| We further show that recombinant TAK 1 , fused to the activation domain of its binding partner TAB 1 , phosphorylates Thr 172 in the activation loop of the AMPK catalytic domain . ^^^ Finally , expression of TAK 1 and TAB 1 in HeLa cells or treatment of cells with cytokines stimulated phosphorylation of Thr 172 of AMPK . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| YopP , but not the catalytically inactive mutant YopP ( C172A ) , also suppresses basal and interleukin 1 inducible activation of endogenous TAK 1 , TAB 1 and TAB 2 . ^^^ YopP does not affect the interaction of TAK 1 , TAB 1 and TAB 2 but inhibits autophosphorylation of TAK 1 at Thr 187 and phosphorylation of TAB 1 at Ser 438 . ^^^ Glutathione S transferase tagged YopP ( GST YopP ) binds to MAPK kinase ( MAPKK ) 4 and TAB 1 but not to TAK 1 or TAB 2 in vitro . ^^^ Furthermore , YopP in synergy with a previously described negative regulatory feedback loop inhibits TAK 1 by MAPKK 6 p38 mediated TAB 1 phosphorylation . ^^^ Taken together , these data strongly suggest that YopP binds to TAB 1 and directly inhibits TAK 1 activity by affecting constitutive TAK 1 and TAB 1 ubiquitination that is required for autoactivation of TAK1 . . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| Using recombinant human dicer we generated siRNA mixtures ( dsiRNA ) directed against the protein kinase TAK 1 and its subunit TAB 1 , important upstream molecules in the pathways activated by IL 1 , TNF , and toll like receptors ( TLR ) . dsiRNA against TAK 1 or TAB 1 significantly suppressed their target proteins as well as TAK 1 mediated activation of NFkappaB , p 38 MAPK , and JNK , and of IL 8 transcription . ^^^ However , microarray analysis of 136 endogenous inflammatory genes revealed that dsiRNA against TAB 1 or TAK 1 did not suppress IL 1 or TNF induced genes but rather induced a broader range of 15 inflammatory genes as well as seven known interferon response genes . ^^^ |
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| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15750 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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