| Interacting proteins: P98170 and O43318 |
Pubmed |
SVM Score :0.5211823 |
| We show that TAK 1 physically interacts with NIK and with IKK 2 , and both XIAP or active TAK 1 can stimulate IKK 2 kinase activity . 0.5211823^^^ |
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| Interacting proteins: P98170 and O43318 |
Pubmed |
SVM Score :0.0 |
| In addition , XIAP , NAIP , and JNK 1 bind to TAK 1 . ^^^ Importantly , expression of catalytically inactive TAK 1 did not affect XIAP inhibition of caspase activity . ^^^ These data suggest that XIAP ' s antiapoptotic activity is achieved by two separate mechanisms : one requiring TAK 1 dependent JNK 1 activation and the second involving caspase inhibition . . ^^^ |
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| Interacting proteins: P98170 and O43318 |
Pubmed |
SVM Score :0.0 |
| The expression of a catalytically inactive mutant of TAK 1 blocked XIAP / ILPIP synergistic activation of JNK 1 thereby implicating TAK 1 in this signaling pathway . ^^^ In vivo co precipitation experiments show that both ILPIP and XIAP interact with TAK 1 and tumor necrosis factor receptor associated factor 6 . ^^^ |
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| Interacting proteins: P98170 and O43318 |
Pubmed |
SVM Score :0.0 |
| X linked inhibitor of apoptosis ( XIAP ) inhibits c Jun N terminal kinase 1 ( JNK 1 ) activation by transforming growth factor beta 1 ( TGF beta 1 ) through ubiquitin mediated proteosomal degradation of the TGF beta 1 activated kinase 1 ( TAK 1 ) . ^^^ We show that NF kappaB plays a role in the up regulation of XIAP gene expression in response to TGF beta 1 treatment and forms a TGF beta 1 inducible complex with TAK 1 . ^^^ Furthermore , we show that the RING domain of XIAP mediates TAK 1 polyubiquitination , which then targets this molecule for proteosomal degradation . ^^^ |
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| Interacting proteins: P98170 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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