| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| Coexpression of downstream kinases , MAP kinase kinase 4 , MAP kinase kinase 6 , and c Jun NH ( 2 ) terminal kinase 1 , but not MAP kinase kinase 3 and p 38 , augmented ARE activation by MEKK 1 , TAK 1 , and ASK 1 . ^^^ |
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| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| MAPKK 6 was shown to phosphorylate and specifically activate the p38 / MPK2 subgroup of the mitogen activated protein kinase superfamily and could be demonstrated to be phosphorylated and activated in vitro by TAK 1 , a recently identified MAPKK kinase . ^^^ Furthermore , when co expressed with TAK 1 in cells in culture , both MAPKK 6 and MKK 3 were strongly activated . ^^^ |
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| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| Expression of dominant negative MKK 6 or dominant negative TAK 1 inhibited the TGF beta induced transcriptional activation as well as the p 38 activation . ^^^ |
|
| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor beta ( TGF beta ) activating kinase 1 ( TAK 1 ) is a novel MAPK kinase kinase that is reported to stimulate the MKK 6 p38K pathway . ^^^ |
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| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| In contrast , activation of stress activated c Jun N terminal kinase and p 38 pathways by expression of constitutively active mutants of Rac , transforming growth factor beta activated kinase 1 ( TAK 1 ) , MAPK kinase 3 ( MKK 3 ) , or MKK 6 or by treatment with arsenite or anisomycin did not alone markedly enhance MMP 1 promoter activity . ^^^ Constitutively active MKK 6 augmented Raf 1 mediated activation of the MMP 1 promoter , whereas active mutants of TAK 1 and MKK3b potently inhibited the stimulatory effect of Raf 1 . ^^^ |
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| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| Moreover , the activity of TAK 1 to phosphorylate MKK 6 , which activates the JNK p 38 kinase pathway , is directly regulated by K 63 linked polyubiquitination . ^^^ |
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| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| Co immunoprecipitation experiments indicated that PP2Cepsilon associates stably with TAK 1 and attenuates the binding of TAK 1 to MKK 4 or MKK 6 . ^^^ Ectopic expression of a phosphatase negative mutant of PP2Cepsilon , PP2Cepsilon ( D / A ) , which acted as a dominant negative form , enhanced both the association between TAK 1 and MKK 4 or MKK 6 and the TAK 1 induced activation of an AP 1 reporter gene . ^^^ |
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| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| S Lipoxygenase 2 mediates arachidonic acid stimulated adhesion of human breast carcinoma cells through the activation of TAK 1 , MKK 6 , and p 38 MAPK . ^^^ |
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| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| Co transfection of IP 10 luciferase with the active forms of the upstream kinases in the MAP kinase cascades , i . e . , MAPK kinase 3 ( MKK 3 ) , MKK 6 ( the immediately upstream activators of p 38 kinase ) and a MAP3K , i . e . , TGFbeta activated kinase 1 ( TAK 1 ) , produced a marked stimulation of the promoter activity . ^^^ |
|
| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P52564 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|