| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.91681967 |
| Mitogen activated protein kinase kinase 4 ( MKK 4 ) / stress activated protein kinase / extracellular signal regulated kinase ( SEK 1 ) , a dual specificity kinase that phosphorylates and activates JNK , synergized with TAK 1 in activating JNK . 0.91681967^^^ |
|
| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| Coexpression of downstream kinases , MAP kinase kinase 4 , MAP kinase kinase 6 , and c Jun NH ( 2 ) terminal kinase 1 , but not MAP kinase kinase 3 and p 38 , augmented ARE activation by MEKK 1 , TAK 1 , and ASK 1 . ^^^ |
|
| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| Dominant negative mutants of HPK 1 downstream effectors , including MEKK 1 , TAK 1 , and SEK 1 , also inhibited Crk induced JNK activation . ^^^ |
|
| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| These results indicate that HGK , a novel activator of the JNK pathway , may function through TAK 1 , and that the HGK > TAK 1 > MKK 4 , MKK 7 > JNK kinase cascade may mediate the TNF alpha signaling pathway . . ^^^ |
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| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| LTbetaR mediated IL 8 response was inhibited by the dominant negative mutants of ASK 1 , MKK 4 , MKK 7 , and JNK , but not by those of MEKK 1 , TAK 1 , MEK , ERK , and p 38 MAPK . ^^^ |
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| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of PP2Cepsilon inhibited the IL 1 and TAK 1 induced activation of mitogen activated protein kinase kinase 4 ( MKK 4 ) c Jun N terminal kinase or MKK 3 p38 signaling pathway . ^^^ Co immunoprecipitation experiments indicated that PP2Cepsilon associates stably with TAK 1 and attenuates the binding of TAK 1 to MKK 4 or MKK 6 . ^^^ Ectopic expression of a phosphatase negative mutant of PP2Cepsilon , PP2Cepsilon ( D / A ) , which acted as a dominant negative form , enhanced both the association between TAK 1 and MKK 4 or MKK 6 and the TAK 1 induced activation of an AP 1 reporter gene . ^^^ |
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| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| The ephrin B 1 mediated JNK activation was reduced significantly by dominant negative TAK 1 , MKK 4 , or MKK 7 . ^^^ |
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| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrated that activities of MAPK kinase 4 ( MKK 4 ) and TAK 1 , one of the upstream kinases of MKK 4 , were enhanced in the neurally differentiating cells . ^^^ Confocal microscopic analysis indicated that TAK 1 , phospho MKK 4 , and phospho JNK were colocalized with tubulin in the neurites and localized also in the nuclei of the differentiating cells . ^^^ |
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| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| Sef and SefIC overexpression also resulted in apoptotic cell death , while dominant negative forms of MKK 4 and TAK 1 blocked Sef mediated JNK activation and attendant 293T cell apoptosis . ^^^ |
|
| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P45985 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|