| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.74608704 |
| Activation of endogenous TAK 1 , a mitogen activated protein kinase ( MAP3K ) regulating the JNK and p 38 MAPK pathways , was induced rapidly by TNF alpha , and co transfection of TAK 1 with its activator protein TAB 1 stimulated activation of JNK and p 38 MAPKs , which led to activation of the transcription factor AP 1 . 0.74608704^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| The TAK 1 MAPKKK mediates activation of JNK and NF KB in the IL 1 activated signaling pathway . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Maximal activation of JNK by lipopolysaccharide requires the MAP3K TAK 1 . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| We show that POSH binds to and degrades TAK 1 , a crucial activator of both the JNK and the Relish signalling pathways . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| The TAK 1 plays a pivotal role in the innate immune response of Drosophila by controlling the activation of JNK and NF kappaB . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| ET 1 induces JNK through TAK 1 . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Thymocytes lacking TAK 1 failed to activate NF kappaB and JNK and were prone to apoptosis upon stimulation . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| X linked inhibitor of apoptosis ( XIAP ) inhibits c Jun N terminal kinase 1 ( JNK 1 ) activation by transforming growth factor beta 1 ( TGF beta 1 ) through ubiquitin mediated proteosomal degradation of the TGF beta 1 activated kinase 1 ( TAK 1 ) . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Expression of a constitutively active form of TAK 1 resulted in activation of SAPK / JNK and SEK1 / MKK4 , a direct activator of SAPK / JNK . ^^^ Furthermore , expression of a kinase negative form of TAK 1 interfered with the activation of SAPK / JNK induced by ceramide . ^^^ These results indicate that TAK 1 may function as a mediator of ceramide signaling to SAPK / JNK activation . . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Activation of the hematopoietic progenitor kinase 1 ( HPK 1 ) dependent , stress activated c Jun N terminal kinase ( JNK ) pathway by transforming growth factor beta ( TGF beta ) activated kinase ( TAK 1 ) , a kinase mediator of TGF beta signal transduction . ^^^ This report shows that TAK 1 is also a strong activator of c Jun N terminal kinase ( JNK ) . ^^^ Both the wild type and a constitutively active mutant of TAK 1 stimulated JNK in transient transfection assays . ^^^ Mitogen activated protein kinase kinase 4 ( MKK 4 ) / stress activated protein kinase / extracellular signal regulated kinase ( SEK 1 ) , a dual specificity kinase that phosphorylates and activates JNK , synergized with TAK 1 in activating JNK . ^^^ Conversely , a dominant negative ( MKK4 / SEK1 mutant inhibited TAK 1 induced JNK activation . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| In transfection assays , curcumin moderately suppressed MEKK 1 induced JNK activation ; however , it effectively blocked JNK activation caused by co transfection of TAK 1 , GCK , or HPK 1 . ^^^ Although curcumin suppressed TAK 1 and GCK activities at high concentrations , this inhibition can not fully account for the JNK inhibition by curcumin in vivo . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| The dominant negative mutant of TAK 1 , but not MEKK 1 or MAPK upstream kinase ( MUK ) , strongly inhibited HGK induced JNK activation . ^^^ These results indicate that HGK , a novel activator of the JNK pathway , may function through TAK 1 , and that the HGK > TAK 1 > MKK 4 , MKK 7 > JNK kinase cascade may mediate the TNF alpha signaling pathway . . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Dominant negative mutants of HPK 1 downstream effectors , including MEKK 1 , TAK 1 , and SEK 1 , also inhibited Crk induced JNK activation . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| We also found that TGF beta induced JNK 1 activation was blocked by a kinase defective mutant of TGF beta activated kinase 1 ( TAK 1 ) . ^^^ Although SEK and MKK 7 acted downstream of TAK 1 , only a kinase defective SEK mutant blocked TGF beta induced activation of JNK 1 , indicating that the TGF beta signal is relayed solely through SEK , but not MKK 7 , in vivo . ^^^ Taken together , these studies establish a potential cascade of TGF beta activated interacting kinases beginning with HPK 1 , a Ste 20 homolog , and ending in JNK 1 activation : HPK 1 > TAK 1 > SEK > JNK1 . . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Genetic and biochemical analyses also indicate that the c Jun amino terminal kinase ( JNK ) signaling pathway is specifically activated by TAK 1 signaling . ^^^ Our results strongly suggest that in Drosophila melanogaster , TAK 1 functions as a MAPKKK in the JNK signaling pathway and participates in such diverse roles as control of cell shape and regulation of apoptosis . . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Here we show that ASK 1 directly interacts with transforming growth factor beta activated kinase 1 ( TAK 1 ) , another MAPKKK that has been identified as a signaling intermediate in the interleukin 1 ( IL 1 ) induced NF kappaB pathway as well as the transforming growth factor beta superfamily induced JNK / p38 pathway . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Expression of the MAP kinase kinase kinase ( MAPKKK ) TAK 1 together with its coactivator TAB 1 in HeLa cells activated all three pathways and was sufficient to induce IL 8 formation , NF kappaB + JNK 2 mediated transcription from a minimal IL 8 promoter , and p 38 MAPK mediated stabilization of a reporter mRNA containing IL 8 derived regulatory mRNA sequences . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| We show that the prototypical pro inflammatory molecule , bacterial lipopolysaccharide , activates multiple protein kinases such as p 38 , JNK , IKK beta , and PKB / Akt via transforming growth factor beta activated kinase 1 ( TAK 1 ) . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Moreover , the activity of TAK 1 to phosphorylate MKK 6 , which activates the JNK p 38 kinase pathway , is directly regulated by K 63 linked polyubiquitination . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| H . pylori LPS stimulated phosphorylation of transforming growth factor beta activated kinase 1 ( TAK 1 ) , TAK 1 binding protein 1 ( TAB 1 ) , and c Jun NH ( 2 ) terminal kinase ( JNK ) 2 . ^^^ Epidermal growth factor blocked all of these apoptotic processes and inhibited apoptosis , whereas it did not modify the phosphorylation of TAK 1 , TAB 1 , and JNK 2 . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| The effect of JNK was assessed by using an adenovirus expressing a dominant negative form of transforming growth factor beta ( TGF beta ) activated kinase 1 ( TAK 1 ) ( Ad5dnTAK1 ) and a new selective pharmacologic inhibitor SP 600125 . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Our findings suggest the existence of a novel mechanism that regulates the anti apoptotic activity of IAPs that is separate from caspase inhibition but instead involves TAK 1 mediated activation of JNK 1 . ^^^ The expression of a catalytically inactive mutant of TAK 1 blocked XIAP / ILPIP synergistic activation of JNK 1 thereby implicating TAK 1 in this signaling pathway . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| However , the effect of inhibiting JNK activation with a dn TAK 1 virus was also specific but was stronger than that via dn TRAF 2 . ^^^ In further experiments , the inhibitory effect of dn TAK 1 on JNK was used to define its role during TNF dependent apoptosis . ^^^ Inhibition of JNK by adv dn TAK 1 resulted in an earlier and stronger induction of apoptosis . ^^^ In conclusion , we define TAK 1 as a kinase specifically involved in TNF induced JNK activation in hepatoma cells and show that JNK transduces antiapoptotic signals , which modulate the strength and time course of FADD dependent cell death involving mitochondrial permeability transfer . . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| LTbetaR mediated IL 8 response was inhibited by the dominant negative mutants of ASK 1 , MKK 4 , MKK 7 , and JNK , but not by those of MEKK 1 , TAK 1 , MEK , ERK , and p 38 MAPK . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| The formation of complex 3 and its interaction with additional cytosolic factors lead to the activation of TAK 1 , resulting in NF kappaB and JNK activation . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Recently , the association of the MAPK kinase kinase , transforming growth factor beta activated kinase 1 ( TAK 1 ) , with TRAF 6 was shown to mediate the IL 1 signaling to NF kappaB and JNK . ^^^ A dominant negative form of TAK 1 was discovered to abolish the RANK induced activation of AP 1 and JNK . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Recently , several MAPKKKs involved in the JNK pathway , such as MEKK 1 , TAK 1 and MLK 3 , were shown , using over expression assay systems , to activate a transcription factor , NF kappaB , through activation of the IKK complex . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| This AKRL1 / 2 induced JNK activation is significantly suppressed by the expression of a kinase negative mutant of TAK 1 , a member of the MAPKKK family . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| The ephrin B 1 mediated JNK activation was reduced significantly by dominant negative TAK 1 , MKK 4 , or MKK 7 . ^^^ Taken together , our findings have identified a novel reverse signaling pathway transduced by ephrin B 1 , which is independent of tyrosine phosphorylation but involves the activation of JNK through TAK 1 and MKK4 / MKK7 and leads to changes in cell morphology . . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAK 1 induced iNOS Luc activity was substantially inhibited by pharmacological inhibitors of the known downstream kinases , p 38 MAPK and JNK ( SB 203580 and SP 620125 ) , and was almost completely blocked by co expression of a phosphorylation mutant of IkappaB . ^^^ The results of these studies provide evidence for an important role for TAK 1 mediated intracellular signaling , via p 38 MAPK , JNK and NFkappaB , in the transcriptional activation of iNOS in glial cells . . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Immune activation of NF kappaB and JNK requires Drosophila TAK 1 . ^^^ Genetic experiments suggest that the Drosophila homolog of the mammalian MAPK kinase kinase , TAK 1 ( transforming growth factor beta activated kinase 1 ) , activates both the JNK and NF kappaB pathways following immune stimulation . ^^^ In this report , we demonstrate that Drosophila TAK 1 functions as both the Drosophila IkappaB kinase activating kinase and the JNK kinase activating kinase . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that TAB 1 participates in a SAPK2a / p38alpha mediated feedback control of TAK 1 , which not only limits the activation of SAPK2a / p38alpha but synchronizes its activity with other signalling pathways that lie downstream of TAK 1 ( JNK and IKK ) . . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Of interest , MEKK 1 immunoprecipitates from IL 1 stimulated FLS appeared to activate c Jun through the JNK pathway and TAK 1 activation of c Jun was dependent on JNK , ERK , and p 38 . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Targeting of TAK 1 by the NF kappa B protein Relish regulates the JNK mediated immune response in Drosophila . ^^^ Relish activation is linked to proteasomal degradation of TAK 1 , the upstream MAP kinase kinase kinase required for JNK activation . ^^^ Degradation of TAK 1 leads to a rapid termination of JNK signaling , resulting in a transient JNK dependent response that precedes the sustained induction of Relish dependent innate immune loci . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Confocal microscopic analysis indicated that TAK 1 , phospho MKK 4 , and phospho JNK were colocalized with tubulin in the neurites and localized also in the nuclei of the differentiating cells . ^^^ These results suggest that two distinct TAK 1 MKK4 JNK signaling pathways are independently activated at the different intracellular locations and may participate in the regulation of the neural differentiation of P 19 cells . . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Sef interacts with TAK 1 and mediates JNK activation and apoptosis . ^^^ Here we show that Sef and a deletion mutant of Sef lacking the extracellular domain ( SefIC ) physically interact with TAK 1 ( transforming growth factor beta associated kinase ) and activate JNK through a TAK 1 MKK4 JNK pathway . ^^^ Sef and SefIC overexpression also resulted in apoptotic cell death , while dominant negative forms of MKK 4 and TAK 1 blocked Sef mediated JNK activation and attendant 293T cell apoptosis . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor ( TGF ) beta , bone morphogenetic protein ( BMP ) , and interleukin 1beta activate TGF beta activated kinase 1 ( TAK 1 ) , which lies upstream of the p 38 MAPK , JNK , and NF kappaB pathways . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAK 1 mitogen activated protein kinase kinase kinase participates in the Interleukin 1 ( IL 1 ) signaling pathway by mediating activation of JNK , p 38 , and NF kappaB . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Simultaneous blockade of NFkappaB , JNK , and p 38 MAPK by a kinase inactive mutant of the protein kinase TAK 1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [ corrected ] target genes . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| We , therefore , delineate a signaling pathway proceeding from the TGFbeta receptors to Dab 2 and TAK 1 , leading to TGFbeta stimulated JNK activation , FN expression , and cell migration . . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Consistent with these , the JNK is remarkably activated in response to ICP 0 , and this JNK activation is shown to be significantly attenuated by TAK 1 ( K63W ) . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| However , TAK 1 deficient B cells were able to activate NF kappaB but not the kinase Jnk in response to B cell receptor stimulation . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| In the TGF beta signaling pathway , TAK 1 deletion leads to impaired NF kappaB and c Jun N terminal kinase ( JNK ) activation without impacting Smad 2 activation or TGF beta induced gene expression . ^^^ Therefore , our studies suggests that TAK 1 acts as an upstream activating kinase for IKKbeta and JNK , but not IKKalpha , revealing an unexpectedly specific role of TAK 1 in inflammatory signaling pathways . . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| TAK 1 is a component of the Epstein Barr virus LMP 1 complex and is essential for activation of JNK but not of NF kappaB . ^^^ Furthermore , we found that ablation of TAK 1 resulted in the loss of LMP 1 induced activation of JNK but not of NF kappaB . ^^^ These results suggest that an LMP 1 associated complex containing TRAF 6 , TAB 2 , and TAK 1 plays an essential role in the activation of JNK . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor beta activated kinase 1 ( TAK 1 ) functions downstream of inflammatory cytokines to activate c Jun N terminal kinase ( JNK ) as well as NF kappaB in several cell types . ^^^ TAK 1 deficient keratinocytes can not activate NF kappaB or JNK upon TNF treatment . ^^^ These results suggest that TNF induces TAK 1 deficient keratinocyte death because of the lack of NF kappaB ( and possibly JNK ) mediated cell survival signaling . ^^^ Transforming growth factor beta activated kinase 1 ( TAK 1 ) functions downstream of inflammatory cytokines to activate c Jun N terminal kinase ( JNK ) as well as NF kappaB in several cell types . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| TLR 8 mediated NF kappaB and JNK activation are TAK 1 independent and MEKK 3 dependent . ^^^ TLR 8 ligands trigger similar levels of IkappaBalpha phosphorylation and NF kappaB and JNK activation in TAK 1 ( / ) mouse embryo fibroblasts ( MEFs ) as compared with wild type MEFs , whereas lack of TAK 1 results in reduced IL 1 mediated NF kappaB activation and abolished IL 1 induced JNK activation . ^^^ The above results indicate that although TLR 8 mediated NF kappaB and JNK activation are IRAK dependent , they do not require IRAK modification and are TAK 1 independent . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| In mature thymocytes , TAK 1 was required for interleukin 7 mediated survival and T cell receptor dependent activation of transcription factor NF kappaB and the kinase Jnk . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| The B1R JIP 1 complex increases the amount of MAPK bound to JIP 1 ; thus , MKK 7 and TAK 1 either bind with higher affinity or bind more stably to JIP 1 , while there is an increase in the phosphorylation state of JNK bound to JIP 1 . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| Using recombinant human dicer we generated siRNA mixtures ( dsiRNA ) directed against the protein kinase TAK 1 and its subunit TAB 1 , important upstream molecules in the pathways activated by IL 1 , TNF , and toll like receptors ( TLR ) . dsiRNA against TAK 1 or TAB 1 significantly suppressed their target proteins as well as TAK 1 mediated activation of NFkappaB , p 38 MAPK , and JNK , and of IL 8 transcription . ^^^ |
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| Interacting proteins: P45983 and O43318 |
Pubmed |
SVM Score :0.0 |
| The MAP 3 kinase , TAK 1 , appears to be an essential component of this antiapoptotic pathway since IAP mediated activation of JNK 1 , as well as protection against TNF alpha and ICE induced apoptosis , is inhibited when catalytically inactive TAK 1 is expressed . ^^^ In addition , XIAP , NAIP , and JNK 1 bind to TAK 1 . ^^^ These data suggest that XIAP ' s antiapoptotic activity is achieved by two separate mechanisms : one requiring TAK 1 dependent JNK 1 activation and the second involving caspase inhibition . . ^^^ |
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