| Interacting proteins: O43318 and P35222 |
Pubmed |
SVM Score :0.50732199 |
| In particular , it has been shown that TAK 1 activates NLK , which phosphorylates TCFs bound to beta catenin . 0.50732199^^^ |
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| Interacting proteins: O43318 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and P35222 |
Pubmed |
SVM Score :0.0 |
| The TAK 1 NLK MAPK related pathway antagonizes signalling between beta catenin and transcription factor TCF . ^^^ Here we show that TAK 1 activation stimulates NLK activity and downregulates transcriptional activation mediated by beta catenin and TCF . ^^^ |
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| Interacting proteins: O43318 and P35222 |
Pubmed |
SVM Score :0.0 |
| The TAK 1 NLK mitogen activated protein kinase cascade functions in the Wnt 5a / Ca ( 2+ ) pathway to antagonize Wnt / beta catenin signaling . ^^^ The mitogen activated protein kinase ( MAPK ) pathway composed of TAK 1 MAPK kinase kinase and NLK MAPK also negatively regulates the canonical Wnt / beta catenin signaling pathway . ^^^ Furthermore , by using a chimeric receptor ( beta ( 2 ) AR Rfz 2 ) containing the ligand binding and transmembrane segments from the beta ( 2 ) adrenergic receptor ( beta ( 2 ) AR ) and the cytoplasmic domains from rat Frizzled 2 ( Rfz 2 ) , stimulation with the beta adrenergic agonist isoproterenol activates activities of endogenous CaMKII , TAK 1 , and NLK and inhibits beta catenin induced transcriptional activation . ^^^ These results suggest that the TAK 1 NLK MAPK cascade is activated by the noncanonical Wnt 5a / Ca ( 2+ ) pathway and antagonizes canonical Wnt / beta catenin signaling . . ^^^ |
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