| Poly ( 1 C ) induced Toll like receptor 3 ( TLR 3 ) mediated activation of NFkappa B and MAP kinase is through an interleukin 1 receptor associated kinase ( IRAK ) independent pathway employing the signaling components TLR 3 TRAF6 TAK 1 TAB2 PKR . ^^^ The dsRNA dependent protein kinase ( PKR ) is also detected in this signal induced TAK 1 complex . ^^^ Kinase inactive mutants of TAK 1 ( TAK1DN ) and PKR ( PKRDN ) inhibit poly ( dI . dC ) induced TLR 3 mediated NFkappaB activation , suggesting that both of these kinases play important roles in this pathway . . ^^^ |