| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.80908462 |
| We show that TAK 1 physically interacts with NIK and with IKK 2 , and both XIAP or active TAK 1 can stimulate IKK 2 kinase activity . 0.80908462^^^ |
|
| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.0 |
| The dominant negative mutant of TAK 1 , but not MEKK 1 or MAPK upstream kinase ( MUK ) , strongly inhibited HGK induced JNK activation . ^^^ These results indicate that HGK , a novel activator of the JNK pathway , may function through TAK 1 , and that the HGK > TAK 1 > MKK 4 , MKK 7 > JNK kinase cascade may mediate the TNF alpha signaling pathway . . ^^^ |
|
| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.0 |
| A dominant negative mutant of NIK did not inhibit TAK 1 induced NF kappa B activation . ^^^ These results suggest that TAK 1 induces NF kappa B activation through a novel NIK independent signaling pathway . . ^^^ |
|
| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.0 |
| The kinase TAK 1 can activate the NIK 1 kappaB as well as the MAP kinase cascade in the IL 1 signalling pathway . ^^^ Here we show that the MAPKK kinase TAK 1 acts upstream of NIK in the IL 1 activated signalling pathway and that TAK 1 associates with TRAF 6 during IL 1 signalling . ^^^ Stimulation of TAK 1 causes activation of NF kappaB , which is blocked by dominant negative mutants of NIK , and an inactive TAK 1 mutant prevents activation of NF kappaB that is mediated by IL 1 but not by NIK . ^^^ Activated TAK 1 phosphorylates NIK , which stimulates IKK alpha activity . ^^^ Our results indicate that TAK 1 links TRAF 6 to the NIK IKK cascade in the IL 1 signalling pathway . . ^^^ |
|
| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.0 |
| Here we report that ASK 1 binds to TAK 1 and dissociates TAK 1 from TNF receptor associated factor 6 ( TRAF 6 ) , and inhibits TAK 1 and TRAF 6 , but not NF kappa B inducing kinase ( NIK ) induced NF kappa B activation . . ^^^ |
|
| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.0 |
| Activation of NF kappa B by nontypeable Hemophilus influenzae is mediated by toll like receptor 2 TAK 1 dependent NIK IKK alpha / beta 1 kappa B alpha and MKK3 / 6 p 38 MAP kinase signaling pathways in epithelial cells . ^^^ Bifurcation of NTHi induced NIK IKK alpha / beta 1 kappa B alpha and MKK3 / 6 p 38 MAP kinase pathways may occur at transforming growth factor beta activated kinase 1 ( TAK 1 ) . ^^^ |
|
| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.0 |
| Reporter assay experiments revealed that A 20 is a very effective inhibitor of NF kappa B signaling induced by TRAFs and several Map 3 kinases , including NIK , MEKK 1 , COT , and TAK 1 . ^^^ |
|
| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.0 |
| Second , the expression of dominant negative mutants of TGF beta activated kinasel ( TAK 1 ) and NF kappaB inducing kinase ( NIK ) , blocked the LPS induced transcriptional activation of RANTES promoter . ^^^ Moreover , the overexpression of TAK 1 along with TAK 1 binding protein 1 ( TAB 1 ) , or NIK stimulated the transcriptional activation of RANTES in the absence of external stimuli . ^^^ These results indicate that NF kappaB mediates LPS triggered RANTES induction and that TAK 1 as well as NIK , as NF kappaB activators participates in LPS triggered RANTES induction . . ^^^ |
|
| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.0 |
| Silica induces nuclear factor kappaB activation through TAK 1 and NIK in Rat 2 cell line . ^^^ In addition , we observed that transforming growth factor beta activated kinase 1 ( TAK 1 ) and NF kappaB inducing kinase ( NIK ) were involved in silica mediated NF kappaB activation in Rat 2 cells . ^^^ The dominant negative mutant forms of TAK 1 and NIK inhibited the silica induced NF kappaB activation in Rat 2 cells . ^^^ |
|
| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.0 |
| Induction of nuclear factor kappaB activation through TAK 1 and NIK by diesel exhaust particles in L 2 cell lines . ^^^ This study showed that DEP induced NF kappaB activity via transforming growth factor beta activated kinase 1 ( TAK 1 ) and NF kappaB inducing kinase ( NIK ) in L 2 rat lung epithelial cells . ^^^ However , this effect was abolished by the expression of the dominant negative forms of TAK 1 or NIK . ^^^ These results suggest that TAK 1 and NIK are important mediators of DEP induced NF kappaB activation . . ^^^ |
|
| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.0 |
| NF kB inducing kinase ( NIK ) and TGF k activated kinase 1 ( TAK 1 ) , the upstream signaling molecules of NF kB , are involved in the silica mediated COX 2 expression . ^^^ |
|
| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95819 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|