| Interacting proteins: O15455 and O43318 |
Pubmed |
SVM Score :0.0 |
| Poly ( 1 C ) induced Toll like receptor 3 ( TLR 3 ) mediated activation of NFkappa B and MAP kinase is through an interleukin 1 receptor associated kinase ( IRAK ) independent pathway employing the signaling components TLR 3 TRAF6 TAK 1 TAB2 PKR . ^^^ Upon binding of dsRNA to TLR 3 , TRAF 6 , TAK 1 , and TAB 2 are recruited to the receptor to form a complex , which then translocates to the cytosol where TAK 1 is phosphorylated and activated . ^^^ Kinase inactive mutants of TAK 1 ( TAK1DN ) and PKR ( PKRDN ) inhibit poly ( dI . dC ) induced TLR 3 mediated NFkappaB activation , suggesting that both of these kinases play important roles in this pathway . . ^^^ |
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| Interacting proteins: O15455 and O43318 |
Pubmed |
SVM Score :0.0 |
| Instead , TRAF 6 , TAK 1 , and TAB 2 are recruited to TLR 3 on poly ( I . ^^^ The present study addressed two important questions : ( 1 ) How are TRAF 6 , TAK 1 , and TAB 2 recruited to TLR 3 . ( 2 ) Are TRAF 6 , TAK 1 , and TAB 2 also required for TLR 3 mediated IRF 3 activation . ^^^ |
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| Interacting proteins: O15455 and O43318 |
Pubmed |
SVM Score :0.0 |
| Upon TLR 3 activation , Rip 1 is also modified by polyubiquitin chains and is recruited to TLR 3 along with Traf 6 and the ubiquitin activated kinase Tak 1 . ^^^ |
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| Interacting proteins: O15455 and O43318 |
Pubmed |
SVM Score :0.0 |
| Using embryonic fibroblasts lacking TAK 1 , TAB 1 , or TAB 2 , we have found that TNFR 1 , IL 1R , TLR 3 , and TLR 4 mediated NF kappaB and AP 1 activation are severely impaired in Tak 1 ( m / m ) cells , but they are normal in Tab 1 ( / ) and Tab 2 ( / ) cells . ^^^ |
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