| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| Activated TAK 1 phosphorylates NIK , which stimulates IKK alpha activity . ^^^ |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| TAK 1 is an important activator of the IkappaB kinase complex in the TLR signaling cascade . ^^^ |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| RKIP physically interacted with four kinases of the NF kappaB activation pathway , NF kappaB inducing kinase , transforming growth factor beta activated kinase 1 , IKKalpha , and IKKbeta . ^^^ |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| Dominant negative mutants of IkappaB kinase ( IKK ) alpha and IKKbeta inhibited TAK 1 induced NF kappaB activation . ^^^ TAK 1 activated IKKalpha and IKKbeta in the presence of TAB 1 . ^^^ IKKalpha and IKKbeta were coimmunoprecipitated with TAK 1 in the absence of TAB 1 . ^^^ TAB 1 induced TAK 1 activation promoted the dissociation of active forms of IKKalpha and IKKbeta from active TAK 1 , whereas the IKK mutants remained to interact with active TAK 1 . ^^^ |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| The TAK 1 TAB1 fusion protein showed a significant MAP3K activity in vitro and activated c Jun N terminal kinase / p38 MAPKs and IkappaB kinase in vivo , which was followed by increased production of interleukin 6 . ^^^ |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| Here , we utilized small interfering RNAs ( siRNAs ) directed against IKKalpha , IKKbeta and the upstream regulatory kinase TAK 1 in order to better define their roles in cytokine induced activation of the NF kappaB pathway . ^^^ TNFalpha activation of the NF kappaB pathway is associated with the inducible binding of TAK 1 to TRAF 2 and both IKKalpha and IKKbeta . ^^^ This analysis further defines the distinct in vivo roles of IKKalpha , IKKbeta and TAK 1 in cytokine induced activation of the NF kappaB pathway . . ^^^ |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| We also determined partial sequence information for myeloid differentiation factor 88 ( MyD 88 ) , two novel TLRs , TNF receptor associated factor 6 ( TRAF 6 ) , TGF beta activated kinase 1 ( TAK 1 ) , TAB 2 , inhibitor of nuclear factor kappa B kinase alpha ( IKK alpha ) and IKK beta . ^^^ |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| In addition , overexpression of TGF beta activated kinase 1 ( TAK 1 ) , IKKalpha and IKKbeta stimulated the phosphorylation , and their dominant negative mutants blocked the TNF alpha induced phosphorylation . ^^^ Moreover , small interfering RNAs ( siRNAs ) against TAK 1 , IKKalpha and IKKbeta blocked the phosphorylation of endogenous p 65 . ^^^ |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| TRAF 6 TAK1 TAB 2 are then translocated to the cytosol where TAK 1 is phosphorylated and activated , leading to the activation of IkappaB kinase and NFkappaB . ^^^ |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| TRAF 6 ( tumor necrosis factor receptor associated factor 6 ) is a RING ( really interesting new gene ) domain ubiquitin ( Ub ) ligase that mediates the activation of protein kinases , such as transforming growth factor beta activated kinase ( TAK 1 ) and IkappaB kinase ( IKK ) , by catalyzing the formation of a unique polyubiquitin chain linked through Lys 63 of Ub . ^^^ |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| Therefore , our studies suggests that TAK 1 acts as an upstream activating kinase for IKKbeta and JNK , but not IKKalpha , revealing an unexpectedly specific role of TAK 1 in inflammatory signaling pathways . . ^^^ |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| The RE / AP driven transcription was regulated by TAK 1 mediated activation of the c Jun NH 2 terminal kinase , p 38 and IkappaB kinase . ^^^ |
|
| Interacting proteins: O43318 and O15111 |
Pubmed |
SVM Score :0.0 |
| Protein interactions of exogenously expressed TNFR associated factor 6 ( TRAF 6 ) and MyD 88 or receptor interacting protein 2 and nucleotide binding oligomerization domain 1 or those of endogenous IkappaB kinase , TGF beta activated kinase 1 ( TAK 1 ) , and TRAF 6 were assessed by immunoprecipitation . ^^^ |
|