Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.97932205 |
We show that TAK 1 physically interacts with NIK and with IKK 2 , and both XIAP or active TAK 1 can stimulate IKK 2 kinase activity . 0.97932205^^^ |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
We show that the prototypical pro inflammatory molecule , bacterial lipopolysaccharide , activates multiple protein kinases such as p 38 , JNK , IKK beta , and PKB / Akt via transforming growth factor beta activated kinase 1 ( TAK 1 ) . ^^^ |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
RKIP physically interacted with four kinases of the NF kappaB activation pathway , NF kappaB inducing kinase , transforming growth factor beta activated kinase 1 , IKKalpha , and IKKbeta . ^^^ |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
Dominant negative mutants of IkappaB kinase ( IKK ) alpha and IKKbeta inhibited TAK 1 induced NF kappaB activation . ^^^ TAK 1 activated IKKalpha and IKKbeta in the presence of TAB 1 . ^^^ IKKalpha and IKKbeta were coimmunoprecipitated with TAK 1 in the absence of TAB 1 . ^^^ TAB 1 induced TAK 1 activation promoted the dissociation of active forms of IKKalpha and IKKbeta from active TAK 1 , whereas the IKK mutants remained to interact with active TAK 1 . ^^^ |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
Here , we utilized small interfering RNAs ( siRNAs ) directed against IKKalpha , IKKbeta and the upstream regulatory kinase TAK 1 in order to better define their roles in cytokine induced activation of the NF kappaB pathway . ^^^ TNFalpha activation of the NF kappaB pathway is associated with the inducible binding of TAK 1 to TRAF 2 and both IKKalpha and IKKbeta . ^^^ This analysis further defines the distinct in vivo roles of IKKalpha , IKKbeta and TAK 1 in cytokine induced activation of the NF kappaB pathway . . ^^^ |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
We also determined partial sequence information for myeloid differentiation factor 88 ( MyD 88 ) , two novel TLRs , TNF receptor associated factor 6 ( TRAF 6 ) , TGF beta activated kinase 1 ( TAK 1 ) , TAB 2 , inhibitor of nuclear factor kappa B kinase alpha ( IKK alpha ) and IKK beta . ^^^ |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
In addition , overexpression of TGF beta activated kinase 1 ( TAK 1 ) , IKKalpha and IKKbeta stimulated the phosphorylation , and their dominant negative mutants blocked the TNF alpha induced phosphorylation . ^^^ Moreover , small interfering RNAs ( siRNAs ) against TAK 1 , IKKalpha and IKKbeta blocked the phosphorylation of endogenous p 65 . ^^^ |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
Furthermore R ( + ) WIN 55 , 212 2 inhibited the ability of overexpressed Myd 88 , Tak 1 , and IKK 2 to induce the reporter gene suggesting that R ( + ) WIN 55 , 212 2 acts at or downstream of IKK 2 in the IL 1 pathway . ^^^ |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
Therefore , our studies suggests that TAK 1 acts as an upstream activating kinase for IKKbeta and JNK , but not IKKalpha , revealing an unexpectedly specific role of TAK 1 in inflammatory signaling pathways . . ^^^ |
|
Interacting proteins: O43318 and O14920 |
Pubmed |
SVM Score :0.0 |
NF kappaB reporter activity induced by TNFR 1 , TNF receptor associated death domain , TRAF 2 , TAK 1 , NF kappaB inducing kinase , and IKKbeta was inhibited by indirubin but not that induced by p 65 transfection . ^^^ |
|