| Interacting proteins: O14733 and O43318 |
Pubmed |
SVM Score :0.0 |
| These results indicate that HGK , a novel activator of the JNK pathway , may function through TAK 1 , and that the HGK > TAK 1 > MKK 4 , MKK 7 > JNK kinase cascade may mediate the TNF alpha signaling pathway . . ^^^ |
|
| Interacting proteins: O14733 and O43318 |
Pubmed |
SVM Score :0.0 |
| Although SEK and MKK 7 acted downstream of TAK 1 , only a kinase defective SEK mutant blocked TGF beta induced activation of JNK 1 , indicating that the TGF beta signal is relayed solely through SEK , but not MKK 7 , in vivo . ^^^ |
|
| Interacting proteins: O14733 and O43318 |
Pubmed |
SVM Score :0.0 |
| LTbetaR mediated IL 8 response was inhibited by the dominant negative mutants of ASK 1 , MKK 4 , MKK 7 , and JNK , but not by those of MEKK 1 , TAK 1 , MEK , ERK , and p 38 MAPK . ^^^ |
|
| Interacting proteins: O14733 and O43318 |
Pubmed |
SVM Score :0.0 |
| The ephrin B 1 mediated JNK activation was reduced significantly by dominant negative TAK 1 , MKK 4 , or MKK 7 . ^^^ |
|
| Interacting proteins: O14733 and O43318 |
Pubmed |
SVM Score :0.0 |
| The B1R JIP 1 complex increases the amount of MAPK bound to JIP 1 ; thus , MKK 7 and TAK 1 either bind with higher affinity or bind more stably to JIP 1 , while there is an increase in the phosphorylation state of JNK bound to JIP 1 . ^^^ |
|
| Interacting proteins: O14733 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14733 and O43318 |
Pubmed |
SVM Score :0.0 |
| NA |
|