| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.51056386 |
| We next expressed matriptase , either alone or with HAI 1 in breast cancer cells that do not endogenously express either protein . 0.51056386^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.81475178 |
| Most of the 24 cell lines released a latent , single chain matriptase of 75 kDa as a major form , as well as low levels of complex forms of an activated two chain enzyme with its specific inhibitor HAI 1 . 0.81475178^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| The present study examined the expression of HGF / SF , HGFA , the two inhibitors to HGFA action known as hepatocyte growth factor activator inhibitors type 1 and 2 ( HAI 1 and HAI 2 ) , and the HGF / SF receptor , c Met . ^^^ The highly invasive breast cancer cells ( MDA MB 231 ) expressed large amounts of both c Met and HGFA , to enable maximum influence from HGF / SF and did not express the HAI 1 gene at all , which suggests a shift in the activation inhibition balance to enhance metastatic potential . ^^^ However , there was no correlation between HAI 1 and HAI 2 expression . ^^^ Interestingly , there appeared to be an inverse correlation between the degree of HGFA and HAI 1 expression , which may influence the metastatic ability of the cancer cells . ^^^ The balance between HGF / SF activation and HGFA inhibition is critical to the metastatic potential of the tumour cells , and the invasive nature of the cancer cell lines correlated to the degree of c Met and / or HGFA presence along with HAI 1 expression . . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is a Kunitz type serine protease inhibitor identified as a strong inhibitor of hepatocyte growth factor ( HGF ) activator and matriptase . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| Expression of the serine protease matriptase and its inhibitor HAI 1 in epithelial ovarian cancer : correlation with clinical outcome and tumor clinicopathological parameters . ^^^ The aim of this study was to examine the expression of matriptase , and its inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , in epithelial ovarian cancer and to assign clinicopathological correlations . ^^^ EXPERIMENTAL DESIGN : We have determined by immunohistochemistry the expression of matriptase and HAI 1 in 54 epithelial ovarian cancers . ^^^ RESULTS : Of 54 tumors tested , 39 ( 72 % ) and 11 ( 20 % ) were positive for matriptase and for HAI 1 , respectively . ^^^ All HAI 1 positive tumors were also matriptase positive . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| Matriptase and its cognate inhibitor , HGF activator inhibitor 1 ( HAI 1 ) colocalize on the cell periphery of breast cancer cells and form stable complexes in the extracellular milieu , suggesting that the inhibitor serves to prevent undesired proteolysis in these cells . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| We examined HGF , matriptase ( an activator of HGF expressed on mammary epithelial cell surfaces ) , HAI 1 ( the cognate inhibitor of matriptase ) , and the Met receptor itself . ^^^ High level expression of Met , matriptase , and HAI 1 were associated with poor patient outcome . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| In tumorigenesis and tissue regeneration , HAI 1 regulates the hepatocyte growth factor ( HGF ) / c Met pathway by inhibiting the activity of HGF activator ( HGFA ) and matriptase , two serine proteases that convert pro HGF into its biologically active form . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| We evaluated the expression of HGFA and its endogenous inhibitors HAI 1 and HAI 2 in normal kidney and RCC . ^^^ MATERIALS AND METHODS : We examined the gene expression of HGFA , HAI 1 , HAI 2 , HGF and MET in a normal kidney by laser captured microdissection , followed by reverse transcriptase polymerase chain reaction . ^^^ RESULTS : HAI 1 and HAI 2 were abundant in the normal kidney . ^^^ The uriniferous tubules showed the highest levels of HAI 1 and HAI 2 mRNA . ^^^ The HAI 1 mRNA level was significantly and consistently down regulated in RCC relative to normal tissue . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| We examined HGF , the HGF receptor ( c Met ) , HGFA , matriptase , and the activation inhibitors ( HAI 1 and HAI 2 ) , tissues from patients with breast cancer . ^^^ HGF , c Met , HGFA , matriptase 1 , HAI 1 , and HAI 2 expression was quantified using real time quantitative PCR . ^^^ RESULTS : The breast cancer specimens expressed a significantly higher level of HGF , c Met , HGFA , HAI 1 , and HAI 2 , but not matriptase , compared with the normal background tissues . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| Activation of single chain , latent matriptase , a type 2 transmembrane serine protease , depends on the weak proteolytic activity of its own zymogen as well as its cognate inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) . ^^^ Oligomerization of matriptase zymogens and HAI 1 , and probably its interaction with other proteins , has been proposed to occur during matriptase activation . ^^^ While matriptase activation can occur at different subcellular locations , both S1P and suramin induced matriptase accumulation form unique subcellular structures , termed activation foci , where oligomerization of matriptase zymogens and HAI 1 may occur , promoting matriptase activation . ^^^ The requirement of HAI 1 for matriptase activation and the coincidence of HAI 1 and matriptase in activation foci apparently provide rapid access of HAI 1 for the inhibition of matriptase immediately after its activation . ^^^ Indeed , all activated matriptase was detected in complexes with HAI 1 only 5 min after suramin stimulation . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| HAI 1 is also a cognate inhibitor of matriptase , a membrane associated serine proteinase . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| Here we show that matriptase possesses a strong oncogenic potential when unopposed by its endogenous inhibitor , HAI 1 . ^^^ Increasing epidermal HAI 1 expression completely negated the oncogenic effects of matriptase . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| Matriptase activation and shedding with HAI 1 is induced by steroid sex hormones in human prostate cancer cells , but not in breast cancer cells . ^^^ Matriptase and its cognate inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , have been implicated in carcinoma onset and malignant progression . ^^^ Activated matriptase was shed in a complex with HAI 1 and may result from simultaneously proteolytic cleavages of both membrane bound proteins . ^^^ Latent matriptase and free HAI 1 were also shed into culture media . ^^^ As a result of shedding , the cellular levels of matriptase and HAI 1 were significantly reduced 24 h after exposure to DHT . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| We have previously demonstrated significantly decreased immunoreactivity of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) , an integral membrane protein that exhibits potent inhibitory activity against hepatocyte growth factor activator ( HGFA ) and matriptase , in colorectal adenocarcinomas . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| Here , we establish the clinical significance of matriptase and its inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , during the progression of human prostate cancer ( CaP ) . ^^^ METHODS : The expression patterns of matriptase and HAI 1 were determined in primary cultures of normal human prostate epithelial ( NHPE ) cells , human CaP cells LNCaP , DU 145 , CWR22Rnu1 , and PC 3 , and in tissue samples of 172 patients with normal prostate , benign prostatic hyperplasia ( BPH ) , prostatic intraepithelial neoplasia ( PIN ) , and adenocarcinoma of different tumor grades . ^^^ CONCLUSION : The increased expression of matriptase and loss of HAI 1 may be an important event during the progression of CaP in humans . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activation inhibitors ( HAI 1 and HAI 2 ) regulate HGF induced invasion of human breast cancer cells . ^^^ HAI 1 and HAI 2 are 2 novel Kunitz type serine protease inhibitors that regulate HGF activity through inhibition of HGFA , matriptase and hepsin action . ^^^ Recent studies demonstrate that HAI 1 and HAI 2 may also potently inhibit a number of other pro metastatic serine proteases and therefore have direct bearing on the spread of tumours . ^^^ Forced expression of either HAI 1 or HAI 2 in these fibroblasts resulted in a dramatic decrease in the production of bioactive hepatocyte growth factor ( HGF ) . ^^^ To further assess the anti cancer properties of HAI 1 and HAI 2 we generated recombinant HAI proteins . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| The ratio of Matriptase / HAI 1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals . ^^^ Overexpression of HAI 1 and matriptase together changed the frequency of carcinoma formation to normal . ^^^ This suggests that the ratio of matriptase to HAI 1 influences the malignant progression . ^^^ The aim of this study has been to determine the ratio of matriptase to HAI 1 mRNA expression in affected and normal tissue from individuals with colorectal cancer adenomas and carcinomas as well as in healthy individuals , in order to determine at which stages a dysregulated ratio of matriptase / HAI 1 mRNA is present during carcinogenesis . ^^^ METHODS : Using quantitative RT PCR , we have determined the mRNA levels for matriptase and HAI 1 in colorectal cancer tissue ( n = 9 ) , severe dysplasia ( n = 15 ) , mild / moderate dysplasia ( n = 21 ) and in normal tissue from the same individuals . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| Activation of the matriptase zymogen requires sequential N terminal cleavage , activation site autocleavage , and transient association with HAI 1 . ^^^ Matriptase and HAI expression are frequently dysregulated in human cancer , and matriptase expression that is unopposed by HAI 1 potently promotes carcinogenesis and metastatic dissemination in animal models . . ^^^ Matriptase and HAI expression are frequently dysregulated in human cancer , and matriptase expression that is unopposed by HAI 1 potently promotes carcinogenesis and metastatic dissemination in animal models . . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| Using COS 1 monkey kidney cells transiently transfected with rat MT SP1 / matriptase expression plasmids , we found that the enzyme is post translationally processed by the cleavage between Gly 149 and Ser 150 , that a portion of the C terminal part ( Ser 150 Val855 ) remains in the cells by association with the NTF ( N terminal fragment ) ( Met 1 Gly149 ) , while the other portions are released into the medium and that the release is increased on activation by co expression with hepatocyte growth factor activator inhibitor type 1 . ^^^ |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43278 and Q9Y5Y6 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.51056386 |
| We next expressed matriptase , either alone or with HAI 1 in breast cancer cells that do not endogenously express either protein . 0.51056386^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.81475178 |
| Most of the 24 cell lines released a latent , single chain matriptase of 75 kDa as a major form , as well as low levels of complex forms of an activated two chain enzyme with its specific inhibitor HAI 1 . 0.81475178^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is a Kunitz type serine protease inhibitor identified as a strong inhibitor of hepatocyte growth factor ( HGF ) activator and matriptase . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is a Kunitz type serine protease inhibitor identified as a strong inhibitor of hepatocyte growth factor ( HGF ) activator and matriptase . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| Expression of the serine protease matriptase and its inhibitor HAI 1 in epithelial ovarian cancer : correlation with clinical outcome and tumor clinicopathological parameters . ^^^ The aim of this study was to examine the expression of matriptase , and its inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , in epithelial ovarian cancer and to assign clinicopathological correlations . ^^^ EXPERIMENTAL DESIGN : We have determined by immunohistochemistry the expression of matriptase and HAI 1 in 54 epithelial ovarian cancers . ^^^ RESULTS : Of 54 tumors tested , 39 ( 72 % ) and 11 ( 20 % ) were positive for matriptase and for HAI 1 , respectively . ^^^ All HAI 1 positive tumors were also matriptase positive . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| Matriptase and its cognate inhibitor , HGF activator inhibitor 1 ( HAI 1 ) colocalize on the cell periphery of breast cancer cells and form stable complexes in the extracellular milieu , suggesting that the inhibitor serves to prevent undesired proteolysis in these cells . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| We examined HGF , matriptase ( an activator of HGF expressed on mammary epithelial cell surfaces ) , HAI 1 ( the cognate inhibitor of matriptase ) , and the Met receptor itself . ^^^ High level expression of Met , matriptase , and HAI 1 were associated with poor patient outcome . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| In tumorigenesis and tissue regeneration , HAI 1 regulates the hepatocyte growth factor ( HGF ) / c Met pathway by inhibiting the activity of HGF activator ( HGFA ) and matriptase , two serine proteases that convert pro HGF into its biologically active form . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| We examined HGF , the HGF receptor ( c Met ) , HGFA , matriptase , and the activation inhibitors ( HAI 1 and HAI 2 ) , tissues from patients with breast cancer . ^^^ HGF , c Met , HGFA , matriptase 1 , HAI 1 , and HAI 2 expression was quantified using real time quantitative PCR . ^^^ RESULTS : The breast cancer specimens expressed a significantly higher level of HGF , c Met , HGFA , HAI 1 , and HAI 2 , but not matriptase , compared with the normal background tissues . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| We have previously demonstrated significantly decreased immunoreactivity of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) , an integral membrane protein that exhibits potent inhibitory activity against hepatocyte growth factor activator ( HGFA ) and matriptase , in colorectal adenocarcinomas . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| Activation of single chain , latent matriptase , a type 2 transmembrane serine protease , depends on the weak proteolytic activity of its own zymogen as well as its cognate inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) . ^^^ Oligomerization of matriptase zymogens and HAI 1 , and probably its interaction with other proteins , has been proposed to occur during matriptase activation . ^^^ While matriptase activation can occur at different subcellular locations , both S1P and suramin induced matriptase accumulation form unique subcellular structures , termed activation foci , where oligomerization of matriptase zymogens and HAI 1 may occur , promoting matriptase activation . ^^^ The requirement of HAI 1 for matriptase activation and the coincidence of HAI 1 and matriptase in activation foci apparently provide rapid access of HAI 1 for the inhibition of matriptase immediately after its activation . ^^^ Indeed , all activated matriptase was detected in complexes with HAI 1 only 5 min after suramin stimulation . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| Using COS 1 monkey kidney cells transiently transfected with rat MT SP1 / matriptase expression plasmids , we found that the enzyme is post translationally processed by the cleavage between Gly 149 and Ser 150 , that a portion of the C terminal part ( Ser 150 Val855 ) remains in the cells by association with the NTF ( N terminal fragment ) ( Met 1 Gly149 ) , while the other portions are released into the medium and that the release is increased on activation by co expression with hepatocyte growth factor activator inhibitor type 1 . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| HAI 1 is also a cognate inhibitor of matriptase , a membrane associated serine proteinase . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| Here we show that matriptase possesses a strong oncogenic potential when unopposed by its endogenous inhibitor , HAI 1 . ^^^ Increasing epidermal HAI 1 expression completely negated the oncogenic effects of matriptase . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| Matriptase activation and shedding with HAI 1 is induced by steroid sex hormones in human prostate cancer cells , but not in breast cancer cells . ^^^ Matriptase and its cognate inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , have been implicated in carcinoma onset and malignant progression . ^^^ Activated matriptase was shed in a complex with HAI 1 and may result from simultaneously proteolytic cleavages of both membrane bound proteins . ^^^ Latent matriptase and free HAI 1 were also shed into culture media . ^^^ As a result of shedding , the cellular levels of matriptase and HAI 1 were significantly reduced 24 h after exposure to DHT . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| Here , we establish the clinical significance of matriptase and its inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , during the progression of human prostate cancer ( CaP ) . ^^^ METHODS : The expression patterns of matriptase and HAI 1 were determined in primary cultures of normal human prostate epithelial ( NHPE ) cells , human CaP cells LNCaP , DU 145 , CWR22Rnu1 , and PC 3 , and in tissue samples of 172 patients with normal prostate , benign prostatic hyperplasia ( BPH ) , prostatic intraepithelial neoplasia ( PIN ) , and adenocarcinoma of different tumor grades . ^^^ CONCLUSION : The increased expression of matriptase and loss of HAI 1 may be an important event during the progression of CaP in humans . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| HAI 1 and HAI 2 are 2 novel Kunitz type serine protease inhibitors that regulate HGF activity through inhibition of HGFA , matriptase and hepsin action . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| The ratio of Matriptase / HAI 1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals . ^^^ Overexpression of HAI 1 and matriptase together changed the frequency of carcinoma formation to normal . ^^^ This suggests that the ratio of matriptase to HAI 1 influences the malignant progression . ^^^ The aim of this study has been to determine the ratio of matriptase to HAI 1 mRNA expression in affected and normal tissue from individuals with colorectal cancer adenomas and carcinomas as well as in healthy individuals , in order to determine at which stages a dysregulated ratio of matriptase / HAI 1 mRNA is present during carcinogenesis . ^^^ METHODS : Using quantitative RT PCR , we have determined the mRNA levels for matriptase and HAI 1 in colorectal cancer tissue ( n = 9 ) , severe dysplasia ( n = 15 ) , mild / moderate dysplasia ( n = 21 ) and in normal tissue from the same individuals . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| Matriptase is a type 2 transmembrane serine protease expressed in most human epithelia , where it is coexpressed with its cognate transmembrane inhibitor , hepatocyte growth factor activator inhibitor ( HAI ) 1 . ^^^ Activation of the matriptase zymogen requires sequential N terminal cleavage , activation site autocleavage , and transient association with HAI 1 . ^^^ Matriptase and HAI expression are frequently dysregulated in human cancer , and matriptase expression that is unopposed by HAI 1 potently promotes carcinogenesis and metastatic dissemination in animal models . . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| The present study examined the expression of HGF / SF , HGFA , the two inhibitors to HGFA action known as hepatocyte growth factor activator inhibitors type 1 and 2 ( HAI 1 and HAI 2 ) , and the HGF / SF receptor , c Met . ^^^ The highly invasive breast cancer cells ( MDA MB 231 ) expressed large amounts of both c Met and HGFA , to enable maximum influence from HGF / SF and did not express the HAI 1 gene at all , which suggests a shift in the activation inhibition balance to enhance metastatic potential . ^^^ However , there was no correlation between HAI 1 and HAI 2 expression . ^^^ Interestingly , there appeared to be an inverse correlation between the degree of HGFA and HAI 1 expression , which may influence the metastatic ability of the cancer cells . ^^^ The balance between HGF / SF activation and HGFA inhibition is critical to the metastatic potential of the tumour cells , and the invasive nature of the cancer cell lines correlated to the degree of c Met and / or HGFA presence along with HAI 1 expression . . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| We evaluated the expression of HGFA and its endogenous inhibitors HAI 1 and HAI 2 in normal kidney and RCC . ^^^ MATERIALS AND METHODS : We examined the gene expression of HGFA , HAI 1 , HAI 2 , HGF and MET in a normal kidney by laser captured microdissection , followed by reverse transcriptase polymerase chain reaction . ^^^ RESULTS : HAI 1 and HAI 2 were abundant in the normal kidney . ^^^ The uriniferous tubules showed the highest levels of HAI 1 and HAI 2 mRNA . ^^^ The HAI 1 mRNA level was significantly and consistently down regulated in RCC relative to normal tissue . ^^^ |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y5Y6 and O43278 |
Pubmed |
SVM Score :0.0 |
| NA |
|