| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.52160573 |
| Here we show that an active form of HGFA is specifically complexed with membrane form HAI 1 , but not with HAI 2 / PB , on the surface of epithelial cells expressing both inhibitors . 0.52160573^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| We previously purified an inhibitor of HGF activator ( HGF activator inhibitor type 1 , HAI 1 ) from the conditioned medium of a human stomach carcinoma cell line MKN 45 and cloned its cDNA . ^^^ Because HAI 2 and HAI 1 are potent inhibitors specific for HGF activator , they may be involved in regulation of proteolytic activation of HGF in injured tissues . . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Recently , HGFA inhibitor 1 ( HAI 1 ) , a novel Kunitz type serine protease inhibitor , has been isolated . ^^^ These results suggest that , in human brain , secreted pro HGF from astrocytes may be activated by HGFA and inhibited by HAI 1 on or near the astrocytic cell surface and that rapid HAI 1 consumption may occur in the white matter in AD . . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Distribution of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in human tissues . ^^^ We used a specific monoclonal antibody to human hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in immunohistochemical procedures to determine the distribution and localization of HAI 1 in human tissues . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is a Kunitz type serine protease inhibitor , which was identified as a potent inhibitor of hepatocyte growth factor ( HGF ) activator from the conditioned medium of a human carcinoma cell line . ^^^ Further , the soluble forms of HAI 1 have different inhibitory activity against HGF activator . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are new Kunitz type serine protease inhibitors that were recently purified and cloned from the human stomach cancer cell line MKN 45 as specific inhibitors against HGF activator . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are recently discovered Kunitz type serine protease inhibitors which can be purified and cloned from human stomach cancer cell line MKN 45 as specific inhibitors against hepatocyte growth factor activator ( HGFA ) . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are recently discovered Kunitz type serine protease inhibitors which can be purified and cloned from human stomach cancer cell line MKN 45 as specific inhibitors against hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| The activity was also inhibited by recombinant HGFA inhibitor type 1 ( HAI 1 ) . ^^^ We examined the expression of HGFA and HAI 1 in human colorectal mucosa and adenoma carcinoma sequence . ^^^ In contrast to HGFA , the expression of HAI 1 decreased significantly in carcinoma cells relative to the adjacent normal or adenoma cells , indicating that the net balance between HGFA and HAI 1 shifts in favor of HGFA in carcinomas . ^^^ Therefore , the balance between HGFA and HAI 1 could play an important role in the regulation of HGF / SF activity in colorectal carcinomas . . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| The HGF activator inhibitor type 1 ( HAI 1 ) was identified as a potent inhibitor of HGF activator ( HGFA ) , a serine proteinase that is responsible for the activation of HGF in vivo . ^^^ In addition to HAI 1 , low but distinct expression of HGFA mRNA was observed in the placenta tissue and cultured cytotrophoblasts by using a sensitive RT PCR method . ^^^ Since HGF plays an essential role in the placenta development , expression of HAI 1 and HGFA may have an important regulatory role in the placenta . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| The present study examined the expression of HGF / SF , HGFA , the two inhibitors to HGFA action known as hepatocyte growth factor activator inhibitors type 1 and 2 ( HAI 1 and HAI 2 ) , and the HGF / SF receptor , c Met . ^^^ The highly invasive breast cancer cells ( MDA MB 231 ) expressed large amounts of both c Met and HGFA , to enable maximum influence from HGF / SF and did not express the HAI 1 gene at all , which suggests a shift in the activation inhibition balance to enhance metastatic potential . ^^^ Interestingly , there appeared to be an inverse correlation between the degree of HGFA and HAI 1 expression , which may influence the metastatic ability of the cancer cells . ^^^ The balance between HGF / SF activation and HGFA inhibition is critical to the metastatic potential of the tumour cells , and the invasive nature of the cancer cell lines correlated to the degree of c Met and / or HGFA presence along with HAI 1 expression . . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) , a Kunitz type serine protease inhibitor for hepatocyte growth factor activator ( HGFA ) , is responsible for proteolytic activation of hepatocyte growth factor . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) , a Kunitz type serine protease inhibitor for hepatocyte growth factor activator ( HGFA ) , is responsible for proteolytic activation of hepatocyte growth factor . ^^^ We examined the expression of HGFA and HAI 1 in liver tissues of chronic liver diseases including hepatocellular carcinoma ( HCC ) . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is a Kunitz type serine protease inhibitor identified as a strong inhibitor of hepatocyte growth factor ( HGF ) activator and matriptase . ^^^ To determine the roles of the Kunitz domains in the inhibitory activity of HAI 1 against serine proteases , we constructed various HAI 1 mutant proteins and examined their inhibitory activity against HGF activator and trypsin . ^^^ These results indicate that Kunitz 1 is the functional domain of HAI 1 for inhibiting the HGF converting activity of HGF activator . ^^^ Furthermore , the presence of two Kunitz domains affected the inhibitory activity of HAI 1 against HGF activator , and it showed a similar , but not additive , level of inhibitory activity against trypsin when compared with that of the individual Kunitz domains . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to examine the expression of matriptase , and its inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , in epithelial ovarian cancer and to assign clinicopathological correlations . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Matriptase and its cognate inhibitor , HGF activator inhibitor 1 ( HAI 1 ) colocalize on the cell periphery of breast cancer cells and form stable complexes in the extracellular milieu , suggesting that the inhibitor serves to prevent undesired proteolysis in these cells . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are recently identified integral membrane Kunitz type proteinase inhibitors . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| The method is based on positive immunoselection using an antibody ( mAb C76 / 18 ) reacting with hepatocyte growth factor activator inhibitor 1 , HAI 1 , a membrane antigen on villous cytotrophoblast . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Tissue expression , protease specificity , and Kunitz domain functions of hepatocyte growth factor activator inhibitor 1B ( HAI 1B ) , a new splice variant of HAI 1 . ^^^ Hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) is an integral membrane protein expressed on epithelial cells and contains two extracellular Kunitz domains ( N terminal KD 1 and C terminal KD 2 ) known to inhibit trypsin like serine proteases . ^^^ In tumorigenesis and tissue regeneration , HAI 1 regulates the hepatocyte growth factor ( HGF ) / c Met pathway by inhibiting the activity of HGF activator ( HGFA ) and matriptase , two serine proteases that convert pro HGF into its biologically active form . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| We evaluated the expression of HGFA and its endogenous inhibitors HAI 1 and HAI 2 in normal kidney and RCC . ^^^ MATERIALS AND METHODS : We examined the gene expression of HGFA , HAI 1 , HAI 2 , HGF and MET in a normal kidney by laser captured microdissection , followed by reverse transcriptase polymerase chain reaction . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Two new HGFA inhibitors , HAI 1 and HAI 2 , inhibit the generation of biologically active HGF , through their interaction with HGFA . ^^^ We examined HGF , the HGF receptor ( c Met ) , HGFA , matriptase , and the activation inhibitors ( HAI 1 and HAI 2 ) , tissues from patients with breast cancer . ^^^ HGF , c Met , HGFA , matriptase 1 , HAI 1 , and HAI 2 expression was quantified using real time quantitative PCR . ^^^ RESULTS : The breast cancer specimens expressed a significantly higher level of HGF , c Met , HGFA , HAI 1 , and HAI 2 , but not matriptase , compared with the normal background tissues . ^^^ CONCLUSIONS : This study shows that there are aberrant levels of HGF , c Met , HGFA , HAI 1 , and HAI 2 expressed in breast cancer tissues compared with background breast tissue . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Roles of hepatocyte growth factor activator ( HGFA ) and its inhibitor HAI 1 in the regeneration of injured gastrointestinal mucosa . ^^^ The activity of HGFA is regulated by two recently identified Kunitz type serine proteinase inhibitors , namely HGFA inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) . ^^^ In vitro study revealed that HAI 1 is not only an inhibitor , but also a specific cell surface binding protein , of active HGFA , and acts as a reservoir of this enzyme on the cell surface . ^^^ Active HGFA / HAI 1 complexes were quickly released from the cell surface by treatment with IL 1beta accompanying significant recovery of HGFA activity in the culture supernatant . ^^^ These results suggest that HAI 1 is a cell surface acceptor of activated HGFA in regenerative epithelial cells , and functions on the cell surface to localize the active HGFA that is going to enter the repair process . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Activation of single chain , latent matriptase , a type 2 transmembrane serine protease , depends on the weak proteolytic activity of its own zymogen as well as its cognate inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) was initially identified as cognate inhibitor of matriptase , a membrane bound serine protease . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| In addition to finding macromolecular hepsin substrates , the extracellular inhibitors of the HGF activator , HAI 1 and HAI 2 , were potent inhibitors of hepsin activity ( IC 50 4+ / 0 . 2 nM and 12+ / 0 . 5 nM respectively ) . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is required for branching morphogenesis in the chorioallantoic placenta . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is a membrane associated Kunitz type serine proteinase inhibitor that was initially identified as a potent inhibitor of hepatocyte growth factor activator . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Paradoxically enhanced immunoreactivity of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in cancer cells at the invasion front . ^^^ We have previously demonstrated significantly decreased immunoreactivity of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) , an integral membrane protein that exhibits potent inhibitory activity against hepatocyte growth factor activator ( HGFA ) and matriptase , in colorectal adenocarcinomas . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Diverse roles of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in the growth of glioblastoma cells in vivo . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is an integral membrane proteinase inhibitor . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| We found the expression profile of prostasin in normal human tissues to correlate highly with hepatocyte growth factor activator inhibitor 1B ( HAI 1B ) and its splice variant HAI 1 . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| AIM : To provide the expression profile of serine protease SNC19 / matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in normal and malignant tissues of gastrointestinal tract at mRNA level for further study on their correlations with tumor progression and metastasis . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Serum hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) in prostate cancer . ^^^ BACKGROUND : Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are Kunitz type serine protease inhibitors for hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| The women ' s plasma concentrations of total HGF , active HGF , active HGF activator ( HGFA ) , HGF activator inhibitor type 1 ( HAI 1 ) and HGF activator inhibitor type 2 ( HAI 2 ) were determined by enzyme linked immunosorbent assay . ^^^ CONCLUSION : A high concentration of HAI 1 during pregnancy may decrease the plasma level of active HGFA . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Matriptase and its cognate inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , have been implicated in carcinoma onset and malignant progression . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Here , we establish the clinical significance of matriptase and its inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , during the progression of human prostate cancer ( CaP ) . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| HAI 1 and HAI 2 are 2 novel Kunitz type serine protease inhibitors that regulate HGF activity through inhibition of HGFA , matriptase and hepsin action . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Mouse hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) / placental bikunin genes and their promoters . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Using COS 1 monkey kidney cells transiently transfected with rat MT SP1 / matriptase expression plasmids , we found that the enzyme is post translationally processed by the cleavage between Gly 149 and Ser 150 , that a portion of the C terminal part ( Ser 150 Val855 ) remains in the cells by association with the NTF ( N terminal fragment ) ( Met 1 Gly149 ) , while the other portions are released into the medium and that the release is increased on activation by co expression with hepatocyte growth factor activator inhibitor type 1 . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Monoclonal antibody ( MAb ) MG 2 was specific to villous cytotrophoblast across gestation , and recognizes hepatocyte growth factor activator inhibitor type 1 . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Gene expression of hepatocyte growth factor activator inhibitor ( HAI ) , a recently identified Kunitz type serine proteinase inhibitor , was analyzed in a series of human colorectal carcinoma cell lines and in human colorectal tissues . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| Matriptase is a type 2 transmembrane serine protease expressed in most human epithelia , where it is coexpressed with its cognate transmembrane inhibitor , hepatocyte growth factor activator inhibitor ( HAI ) 1 . ^^^ |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43278 and Q04756 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.52160573 |
| Here we show that an active form of HGFA is specifically complexed with membrane form HAI 1 , but not with HAI 2 / PB , on the surface of epithelial cells expressing both inhibitors . 0.52160573^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans ' cells of human placenta . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Mouse hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) / placental bikunin genes and their promoters . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| The present study examined the expression of HGF / SF , HGFA , the two inhibitors to HGFA action known as hepatocyte growth factor activator inhibitors type 1 and 2 ( HAI 1 and HAI 2 ) , and the HGF / SF receptor , c Met . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Gene expression of hepatocyte growth factor activator inhibitor ( HAI ) , a recently identified Kunitz type serine proteinase inhibitor , was analyzed in a series of human colorectal carcinoma cell lines and in human colorectal tissues . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Distribution of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in human tissues . ^^^ We used a specific monoclonal antibody to human hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in immunohistochemical procedures to determine the distribution and localization of HAI 1 in human tissues . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is a Kunitz type serine protease inhibitor , which was identified as a potent inhibitor of hepatocyte growth factor ( HGF ) activator from the conditioned medium of a human carcinoma cell line . ^^^ Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are recently discovered Kunitz type serine protease inhibitors which can be purified and cloned from human stomach cancer cell line MKN 45 as specific inhibitors against hepatocyte growth factor activator ( HGFA ) . ^^^ Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Tissue expression , protease specificity , and Kunitz domain functions of hepatocyte growth factor activator inhibitor 1B ( HAI 1B ) , a new splice variant of HAI 1 . ^^^ Hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) is an integral membrane protein expressed on epithelial cells and contains two extracellular Kunitz domains ( N terminal KD 1 and C terminal KD 2 ) known to inhibit trypsin like serine proteases . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Paradoxically enhanced immunoreactivity of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in cancer cells at the invasion front . ^^^ We have previously demonstrated significantly decreased immunoreactivity of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) , an integral membrane protein that exhibits potent inhibitory activity against hepatocyte growth factor activator ( HGFA ) and matriptase , in colorectal adenocarcinomas . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Activation of single chain , latent matriptase , a type 2 transmembrane serine protease , depends on the weak proteolytic activity of its own zymogen as well as its cognate inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) , a Kunitz type serine protease inhibitor for hepatocyte growth factor activator ( HGFA ) , is responsible for proteolytic activation of hepatocyte growth factor . ^^^ Expression of hepatocyte growth factor activator and hepatocyte growth factor activator inhibitor type 1 in human hepatocellular carcinoma . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is a Kunitz type serine protease inhibitor identified as a strong inhibitor of hepatocyte growth factor ( HGF ) activator and matriptase . ^^^ Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1 . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to examine the expression of matriptase , and its inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , in epithelial ovarian cancer and to assign clinicopathological correlations . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are recently identified integral membrane Kunitz type proteinase inhibitors . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Roles of hepatocyte growth factor activator ( HGFA ) and its inhibitor HAI 1 in the regeneration of injured gastrointestinal mucosa . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| The method is based on positive immunoselection using an antibody ( mAb C76 / 18 ) reacting with hepatocyte growth factor activator inhibitor 1 , HAI 1 , a membrane antigen on villous cytotrophoblast . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Using COS 1 monkey kidney cells transiently transfected with rat MT SP1 / matriptase expression plasmids , we found that the enzyme is post translationally processed by the cleavage between Gly 149 and Ser 150 , that a portion of the C terminal part ( Ser 150 Val855 ) remains in the cells by association with the NTF ( N terminal fragment ) ( Met 1 Gly149 ) , while the other portions are released into the medium and that the release is increased on activation by co expression with hepatocyte growth factor activator inhibitor type 1 . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) was initially identified as cognate inhibitor of matriptase , a membrane bound serine protease . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is required for branching morphogenesis in the chorioallantoic placenta . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is a membrane associated Kunitz type serine proteinase inhibitor that was initially identified as a potent inhibitor of hepatocyte growth factor activator . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Diverse roles of hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in the growth of glioblastoma cells in vivo . ^^^ Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) is an integral membrane proteinase inhibitor . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| We found the expression profile of prostasin in normal human tissues to correlate highly with hepatocyte growth factor activator inhibitor 1B ( HAI 1B ) and its splice variant HAI 1 . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| AIM : To provide the expression profile of serine protease SNC19 / matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) in normal and malignant tissues of gastrointestinal tract at mRNA level for further study on their correlations with tumor progression and metastasis . ^^^ Expression of serine protease SNC19 / matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Serum hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) in prostate cancer . ^^^ BACKGROUND : Hepatocyte growth factor activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are Kunitz type serine protease inhibitors for hepatocyte growth factor activator ( HGFA ) . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Matriptase and its cognate inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , have been implicated in carcinoma onset and malignant progression . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Here , we establish the clinical significance of matriptase and its inhibitor , hepatocyte growth factor activator inhibitor 1 ( HAI 1 ) , during the progression of human prostate cancer ( CaP ) . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Monoclonal antibody ( MAb ) MG 2 was specific to villous cytotrophoblast across gestation , and recognizes hepatocyte growth factor activator inhibitor type 1 . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Matriptase is a type 2 transmembrane serine protease expressed in most human epithelia , where it is coexpressed with its cognate transmembrane inhibitor , hepatocyte growth factor activator inhibitor ( HAI ) 1 . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Recently , HGFA inhibitor 1 ( HAI 1 ) , a novel Kunitz type serine protease inhibitor , has been isolated . ^^^ These results suggest that , in human brain , secreted pro HGF from astrocytes may be activated by HGFA and inhibited by HAI 1 on or near the astrocytic cell surface and that rapid HAI 1 consumption may occur in the white matter in AD . . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| The activity was also inhibited by recombinant HGFA inhibitor type 1 ( HAI 1 ) . ^^^ We examined the expression of HGFA and HAI 1 in human colorectal mucosa and adenoma carcinoma sequence . ^^^ In contrast to HGFA , the expression of HAI 1 decreased significantly in carcinoma cells relative to the adjacent normal or adenoma cells , indicating that the net balance between HGFA and HAI 1 shifts in favor of HGFA in carcinomas . ^^^ Therefore , the balance between HGFA and HAI 1 could play an important role in the regulation of HGF / SF activity in colorectal carcinomas . . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| We evaluated the expression of HGFA and its endogenous inhibitors HAI 1 and HAI 2 in normal kidney and RCC . ^^^ MATERIALS AND METHODS : We examined the gene expression of HGFA , HAI 1 , HAI 2 , HGF and MET in a normal kidney by laser captured microdissection , followed by reverse transcriptase polymerase chain reaction . ^^^ The expression of the 2 HAIs was significantly down regulated in RCC , whereas HGFA expression was enhanced in the diseased kidney , suggesting an imbalance between HAI and its target proteinases , including HGFA , in favor of proteinase activities in RCC . . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Two new HGFA inhibitors , HAI 1 and HAI 2 , inhibit the generation of biologically active HGF , through their interaction with HGFA . ^^^ We examined HGF , the HGF receptor ( c Met ) , HGFA , matriptase , and the activation inhibitors ( HAI 1 and HAI 2 ) , tissues from patients with breast cancer . ^^^ HGF , c Met , HGFA , matriptase 1 , HAI 1 , and HAI 2 expression was quantified using real time quantitative PCR . ^^^ RESULTS : The breast cancer specimens expressed a significantly higher level of HGF , c Met , HGFA , HAI 1 , and HAI 2 , but not matriptase , compared with the normal background tissues . ^^^ CONCLUSIONS : This study shows that there are aberrant levels of HGF , c Met , HGFA , HAI 1 , and HAI 2 expressed in breast cancer tissues compared with background breast tissue . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| The women ' s plasma concentrations of total HGF , active HGF , active HGF activator ( HGFA ) , HGF activator inhibitor type 1 ( HAI 1 ) and HGF activator inhibitor type 2 ( HAI 2 ) were determined by enzyme linked immunosorbent assay . ^^^ CONCLUSION : A high concentration of HAI 1 during pregnancy may decrease the plasma level of active HGFA . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| HAI 1 and HAI 2 are 2 novel Kunitz type serine protease inhibitors that regulate HGF activity through inhibition of HGFA , matriptase and hepsin action . ^^^ |
|
| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| We previously purified an inhibitor of HGF activator ( HGF activator inhibitor type 1 , HAI 1 ) from the conditioned medium of a human stomach carcinoma cell line MKN 45 and cloned its cDNA . ^^^ Because HAI 2 and HAI 1 are potent inhibitors specific for HGF activator , they may be involved in regulation of proteolytic activation of HGF in injured tissues . . ^^^ |
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| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) activator inhibitor type 1 ( HAI 1 ) and type 2 ( HAI 2 ) are new Kunitz type serine protease inhibitors that were recently purified and cloned from the human stomach cancer cell line MKN 45 as specific inhibitors against HGF activator . ^^^ |
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| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| Matriptase and its cognate inhibitor , HGF activator inhibitor 1 ( HAI 1 ) colocalize on the cell periphery of breast cancer cells and form stable complexes in the extracellular milieu , suggesting that the inhibitor serves to prevent undesired proteolysis in these cells . ^^^ |
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| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| In addition to finding macromolecular hepsin substrates , the extracellular inhibitors of the HGF activator , HAI 1 and HAI 2 , were potent inhibitors of hepsin activity ( IC 50 4+ / 0 . 2 nM and 12+ / 0 . 5 nM respectively ) . ^^^ |
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| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and O43278 |
Pubmed |
SVM Score :0.0 |
| NA |
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