| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| RTA KDEL and RTA YQRL respectively exhibited 6 . 7 fold and 6 . 1 fold more protection against papain digestion in reconstituted ER vesicles and 2 . 2 fold and 1 . 8 fold more protection in reconstituted Golgi vesicles , than unmodified rRTA . ^^^ |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| Addition of a KDEL sequence to RTA increases fluid phase uptake , consistent with the notion that transport to the ER is important for cytotoxicity . ^^^ |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| RTA is thought to translocate into the cytosol from the lumen of the endoplasmic reticulum ( ER ) , although how it traverses the ER membrane has not been established . ^^^ Using yeast mutants defective in various aspects of the ER associated protein degradation ( ERAD ) pathway , we show that RTA introduced into the yeast ER subverts this pathway to enter the cytosol via the Sec61p translocon . ^^^ |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| The relative transcription activity ( RTA ) of ER alpha correlated with Dif 0 Dif1 , while RTA of ER beta correlated with H bonding and polarity . ^^^ |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| During cell entry , ricin undergoes retrograde vesicular transport to reach the endoplasmic reticulum ( ER ) lumen , from where RTA translocates into the cytosol , probably by masquerading as a substrate for the ER associated protein degradation ( ERAD ) pathway . ^^^ |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| Mutation of the RNA recognition motif alters RNA binding specificity and results in a dominant negative form of RTA that leads to derepression of ERalpha transcriptional activity , allowing all classes of antiestrogens to manifest partial agonist activity and enhancing agonist efficacy . ^^^ |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| Several protein toxins , including the A chain of ricin ( RTA ) , enter mammalian cells by endocytosis and subsequently reach their cytosolic substrates by translocation across the endoplasmic reticulum ( ER ) membrane . ^^^ |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| To target ribosome in the mammalian cytosol , ricin must firstly retrograde transport from the endomembrane system to reach the endoplasmic reticulum ( ER ) where the ricin A chain ( RTA ) is recognized by ER components that facilitate its membrane translocation to the cytosol . ^^^ |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| Trends in RTA related spinal injuries : the post penalty points era . ^^^ |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43251 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|