| The tagged Sept 4 and alpha synuclein synergistically accelerated cell death induced by the proteasome inhibitor , and this effect was further enhanced by expression of another Lewy body associated protein , synphilin 1 , tagged with the V 5 epitope . ^^^ Moreover , co expression of the three proteins ( tagged Sept 4 , alpha synuclein , and synphilin 1 ) was sufficient to induce cell death . ^^^ |