| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.76928727 |
| It is likely , therefore , that whereas during early development Fgfr 2 interacts with Fgf 4 , in limb and lung development interactions between Fgf 10 and Fgfr 2 may be required . 0.76928727^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| We identified heterozygous mutations in the tyrosine kinase domains of the genes encoding fibroblast growth factor receptors 2 and 3 ( FGFR 2 , FGFR 3 ) in LADD families , and in one further LADD family , we detected a mutation in the gene encoding fibroblast growth factor 10 ( FGF 10 ) , a known FGFR ligand . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| Fibroblast growth factor receptor 2 ( FGFR 2 ) mediated reciprocal regulation loop between FGF 8 and FGF 10 is essential for limb induction . ^^^ Fibroblast growth factor receptor 2 ( FGFR 2 ) mediated reciprocal regulation loop between FGF 8 and FGF 10 is essential for limb induction . ^^^ These findings provide direct genetic evidence that FGF / FGFR2 signals are absolutely required for vertebrate limb induction and that an FGFR 2 signal is essential for the reciprocal regulation loop between FGF 8 and FGF 10 during limb induction . . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| Within this concentration range , FGF 10 did not stimulate DNA synthesis in NIH / 3T3 mouse fibroblasts . rFGF 10 bound the KGFR with high affinity comparable to that of KGF , and did not bind detectably to either the FGFR1c ( Flg ) or FGFR2c ( Bek ) receptor isoforms . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| We show here that FGFR 2 IIIb and its ligands FGF 1 , FGF 7 , and FGF 10 are expressed throughout pancreatic development . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| The expression of the KGF receptor ( KGFR ) and its stromal ligands , KGF and FGF 10 , was compared during mouse mammary gland development . ^^^ Differences in the level and pattern of expression of mRNA for KGF , FGF 10 , and the KGFR during postnatal development of the mouse mammary gland are a result of morphological development , changes in the ratio of stroma to epithelium , and hormonal regulation of cell differentiation . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| Interactions between FGF 10 and the IIIb isoform of FGFR 2 appear to be crucial for the induction and growth of several organs , particularly those that involve budding morphogenesis . ^^^ FGF 10 and FGFR 2 ( IIIb ) mRNAs showed distinct , largely nonoverlapping expression patterns in the undifferentiated otic epithelium . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| We show that the S252W mutation allows the mesenchymal splice form of FGFR 2 ( FGFR2c ) to bind and to be activated by the mesenchymally expressed ligands FGF 7 or FGF 10 and the epithelial splice form of FGFR 2 ( FGFR2b ) to be activated by FGF 2 , FGF 6 , and FGF 9 . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| Its absence did not prevent expression of Fgf 8 , Fgf 10 , Bmp 4 , and Msx 1 , but did prevent induction of Shh and Fgf 4 , indicating that they are downstream targets of FgfR 2 IIIb activation . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| However , treatment with exogenous FGF 10 or antisense Fgf 10 did not change Shh and FgfR 2 mRNA levels in the lungs . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| In the present study , the expression of FGF 10 and FGFR 2 iiib in five cultured human colorectal adenocarcinoma cell lines ( COLO 205 , DLD 1 , HCT 15 , SW 480 and WiDr ) and the localization of FGF 10 messenger RNA ( mRNA ) and its protein in human colorectal cancer tissues from 10 patients were determined . ^^^ FGFR 2 iiib mRNAs were expressed in these cells and the recombinant FGF 10 ( 1 ng / ml ) increased the growth rate of COLO 205 cells . ^^^ These findings indicate that FGF 10 and its receptor , FGFR 2 iiib expression in colorectal adenocarcinoma cells and FGF 10 may contribute to the growth of cells of this type . . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| In the Twist ( / ) forelimb bud , Fgf 10 expression is reduced , Fgf 4 is not expressed , and the domain of Fgf 8 and Fgfr 2 expression is altered . ^^^ Fgf4 and Fgf 8 expression is lost or reduced in the apical ectoderm , but other genes ( Fgf 10 , Fgfr 2 ) involved with FGF signalling are expressed in normal patterns . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| Recently it was shown that Fgf 10 , a major ligand for the IIIb isoform of fibroblast growth factor receptor 2 ( Fgfr2b ) , has an important regulatory role in early pancreas development . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that FGF 7 and FGF 10 contribute to the regeneration and differentiation of acinar cells and angiogenesis in AP through KGFR . . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| FGF 7 and FGF 10 activate only the b isoform of FGFR 2 ( FGFR2b ) . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| In an effort to determine the possible genetic causes of neonatal death and organ abnormalities , we used real time quantitative reverse transcription polymerase chain reaction to examine expression patterns of eight developmentally important genes ( PCAF , Xist , FGFR 2 , PDGFRa , FGF 10 , BMP 4 , Hsp70 . 1 , and VEGF ) in six organs ( heart , liver , spleen , lung , kidney , and brain ) of both cloned bovines that died soon after birth ( n=9 ) and normal control calves produced by artificial insemination . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that antagonism of the androgen receptor ( AR ) leads to loss of Fgfr 2 IIIb and Fgf 10 expression in the urethra , and an associated hypospadias phenotype , suggesting that these genes are downstream targets of AR during external genital development . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| While these results confirm the established notion that FGFR 2 IIIB ligands ( FGF 7 and FGF 10 ) are important for wound healing , they also suggest that decreased expression of multiple FGF ligands contributes to the slowing of wound healing in aged mice and indicate the potential importance of further study of the involvement of FGF 9 , 16 , 18 and 23 in the wound healing process . . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| To better understand the function of FGFR 2 in mandibular morphogenesis , we have analysed the expression Fgfr2b , Fgfr2c and their putative ligands Fgf 10 and Fgf 9 , in the developing chick mandibular processes by in situ hybridisation and RT PCR . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| The signaling pathways between endoderm derived gastric epithelium and the surrounding mesenchyme are largely unknown ; however , the developmental expression profile of the IIIb isoform of Fgfr 2 ( Fgfr2b ) and its main ligand , Fgf 10 , suggest that they may be strong candidates . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| Keratinocyte growth factor 2 ( KGF 2 ) is found in dermal papilla fibroblasts and its receptor , fibroblast growth factor receptor 2 ( FGFR 2 ) , in the neighboring outer root sheath of keratinocytes . ^^^ |
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| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15520 and P21802 |
Pubmed |
SVM Score :0.0 |
| NA |
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