| Interacting proteins: O15516 and Q8WYA1 |
Pubmed |
SVM Score :0.87716636 |
| In endothelial cells , CLIF forms a heterodimer with CLOCK and up regulates the PAI 1 gene through E box sites . 0.87716636^^^ |
|
| Interacting proteins: O15516 and Q8WYA1 |
Pubmed |
SVM Score :0.0 |
| Like its homologs , MOP 9 forms a transcriptionally active heterodimer with the circadian CLOCK protein , the structurally related MOP 4 , and hypoxia inducible factors , such as HIF1alpha . ^^^ Importantly , MOP 9 is coexpressed with CLOCK in the suprachiasmatic nucleus , the site of the master circadian oscillator in mammals . . ^^^ |
|
| Interacting proteins: O15516 and Q8WYA1 |
Pubmed |
SVM Score :0.0 |
| Brain Muscle Arnt Like protein 2 ( BMAL 2 ; Arnt 4 ) ( aryl hydrocarbon receptor nuclear translocator ) is a recently identified basic Helix Loop Helix Per Arnt Sim ( bHLH PAS ) transcription factor , which contributes to a positive regulation of autoregulatory feedback loop in vertebrate circadian clock systems . ^^^ |
|
| Interacting proteins: O15516 and Q8WYA1 |
Pubmed |
SVM Score :0.0 |
| We also show that Clock , Bmal 1 , and Bmal 2 all oscillate under LD and dark dark conditions with similar kinetics , but only Clock is significantly induced while initiating a light induced circadian oscillation in Z 3 cells that have never been exposed to a LD cycle . ^^^ |
|
| Interacting proteins: O15516 and Q8WYA1 |
Pubmed |
SVM Score :0.0 |
| Chicken pineal clock genes : implication of BMAL 2 as a bidirectional regulator in circadian clock oscillation . ^^^ RESULTS : We identified expression of the Per 2 , Bmal 1 , Bmal 2 and Clock genes in the chicken pineal gland . ^^^ CONCLUSION : The functional characterization of the chicken pineal clock molecules supports the key roles of BMAL 1 , BMAL 2 and CLOCK which contribute to the E box dependent transcriptional regulation in the circadian clock system . . ^^^ |
|
| Interacting proteins: O15516 and Q8WYA1 |
Pubmed |
SVM Score :0.0 |
| Because CLIF is expressed in vascular endothelial cells and forms a heterodimer with CLOCK , the key transcription factor controlling the circadian rhythm , we hypothesized that CLIF regulates the circadian oscillation of PAI 1 gene expression in endothelial cells . ^^^ In endothelial cells , the heterodimer of CLIF and CLOCK upregulated the PAI 1 gene expression through E box sites . ^^^ Furthermore , Period and Cryptochrome , which are negative regulators in the feedback loop of the biological clock , inhibited PAI 1 promoter activation by the CLOCK : CLIF heterodimer . ^^^ These results suggest that the peripheral tissues have their own biological clock and CLIF regulates the circadian oscillation of PAI 1 gene expression in endothelial cells . ^^^ |
|
| Interacting proteins: O15516 and Q8WYA1 |
Pubmed |
SVM Score :0.0 |
| The functional consequences of alternative splicing for transcriptional activation by CLOCK : BMAL 2 heterodimers were assessed using luciferase reporter gene constructs that contained one of three diurnally regulated promoters , namely , those of the mouse period 1 , mouse vasopressin , and human plasminogen activator inhibitor 1 genes . ^^^ Indeed , alternative splicing of BMAL 2 may provide tissues with a rheostat capable of regulating CLOCK : BMAL 2 heterodimer function across a broad continuum of potential transcriptional activities to accommodate varied metabolic demands and physiological roles . . ^^^ |
|
| Interacting proteins: O15516 and Q8WYA1 |
Pubmed |
SVM Score :0.0 |
| Regulation of the PAI 1 promoter by circadian clock components : differential activation by BMAL 1 and BMAL 2 . ^^^ Both CLOCK : BMAL 1 and CLOCK : BMAL 2 heterodimers activate the PAI 1 promoter through requisite proximal ( 565 to 560 bp ) and distal ( 680 to 675 bp ) E box enhancers . ^^^ Although the distal E box overlaps the 4G / 5G polymorphism of the PAI 1 promoter , allelic variation at this site does not influence CLOCK : BMAL 1 and CLOCK : BMAL 2 mediated transactivation . ^^^ Together , CLOCK : BMAL 1 and CLOCK : BMAL 2 make additive contributions to PAI 1 gene transcription . ^^^ |
|
| Interacting proteins: O15516 and Q8WYA1 |
Pubmed |
SVM Score :0.0 |
| Additionally , expressions of Per 1 , Per 2 , Per 3 , Bmal 1 , Bmal 2 , Clock , Cry 1 , and Cry 2 clock genes were simultaneously detected in single chicken pineal glands . . ^^^ |
|
| Interacting proteins: Q8WYA1 and O15516 |
Pubmed |
SVM Score :0.87716636 |
| In endothelial cells , CLIF forms a heterodimer with CLOCK and up regulates the PAI 1 gene through E box sites . 0.87716636^^^ |
|
| Interacting proteins: Q8WYA1 and O15516 |
Pubmed |
SVM Score :0.0 |
| Because CLIF is expressed in vascular endothelial cells and forms a heterodimer with CLOCK , the key transcription factor controlling the circadian rhythm , we hypothesized that CLIF regulates the circadian oscillation of PAI 1 gene expression in endothelial cells . ^^^ In endothelial cells , the heterodimer of CLIF and CLOCK upregulated the PAI 1 gene expression through E box sites . ^^^ Furthermore , Period and Cryptochrome , which are negative regulators in the feedback loop of the biological clock , inhibited PAI 1 promoter activation by the CLOCK : CLIF heterodimer . ^^^ These results suggest that the peripheral tissues have their own biological clock and CLIF regulates the circadian oscillation of PAI 1 gene expression in endothelial cells . ^^^ |
|
| Interacting proteins: Q8WYA1 and O15516 |
Pubmed |
SVM Score :0.0 |
| Additionally , expressions of Per 1 , Per 2 , Per 3 , Bmal 1 , Bmal 2 , Clock , Cry 1 , and Cry 2 clock genes were simultaneously detected in single chicken pineal glands . . ^^^ |
|
| Interacting proteins: Q8WYA1 and O15516 |
Pubmed |
SVM Score :0.0 |
| Like its homologs , MOP 9 forms a transcriptionally active heterodimer with the circadian CLOCK protein , the structurally related MOP 4 , and hypoxia inducible factors , such as HIF1alpha . ^^^ Importantly , MOP 9 is coexpressed with CLOCK in the suprachiasmatic nucleus , the site of the master circadian oscillator in mammals . . ^^^ |
|
| Interacting proteins: Q8WYA1 and O15516 |
Pubmed |
SVM Score :0.0 |
| Brain Muscle Arnt Like protein 2 ( BMAL 2 ; Arnt 4 ) ( aryl hydrocarbon receptor nuclear translocator ) is a recently identified basic Helix Loop Helix Per Arnt Sim ( bHLH PAS ) transcription factor , which contributes to a positive regulation of autoregulatory feedback loop in vertebrate circadian clock systems . ^^^ |
|
| Interacting proteins: Q8WYA1 and O15516 |
Pubmed |
SVM Score :0.0 |
| We also show that Clock , Bmal 1 , and Bmal 2 all oscillate under LD and dark dark conditions with similar kinetics , but only Clock is significantly induced while initiating a light induced circadian oscillation in Z 3 cells that have never been exposed to a LD cycle . ^^^ |
|
| Interacting proteins: Q8WYA1 and O15516 |
Pubmed |
SVM Score :0.0 |
| Chicken pineal clock genes : implication of BMAL 2 as a bidirectional regulator in circadian clock oscillation . ^^^ RESULTS : We identified expression of the Per 2 , Bmal 1 , Bmal 2 and Clock genes in the chicken pineal gland . ^^^ CONCLUSION : The functional characterization of the chicken pineal clock molecules supports the key roles of BMAL 1 , BMAL 2 and CLOCK which contribute to the E box dependent transcriptional regulation in the circadian clock system . . ^^^ |
|
| Interacting proteins: Q8WYA1 and O15516 |
Pubmed |
SVM Score :0.0 |
| The functional consequences of alternative splicing for transcriptional activation by CLOCK : BMAL 2 heterodimers were assessed using luciferase reporter gene constructs that contained one of three diurnally regulated promoters , namely , those of the mouse period 1 , mouse vasopressin , and human plasminogen activator inhibitor 1 genes . ^^^ Indeed , alternative splicing of BMAL 2 may provide tissues with a rheostat capable of regulating CLOCK : BMAL 2 heterodimer function across a broad continuum of potential transcriptional activities to accommodate varied metabolic demands and physiological roles . . ^^^ |
|
| Interacting proteins: Q8WYA1 and O15516 |
Pubmed |
SVM Score :0.0 |
| Regulation of the PAI 1 promoter by circadian clock components : differential activation by BMAL 1 and BMAL 2 . ^^^ Both CLOCK : BMAL 1 and CLOCK : BMAL 2 heterodimers activate the PAI 1 promoter through requisite proximal ( 565 to 560 bp ) and distal ( 680 to 675 bp ) E box enhancers . ^^^ Although the distal E box overlaps the 4G / 5G polymorphism of the PAI 1 promoter , allelic variation at this site does not influence CLOCK : BMAL 1 and CLOCK : BMAL 2 mediated transactivation . ^^^ Together , CLOCK : BMAL 1 and CLOCK : BMAL 2 make additive contributions to PAI 1 gene transcription . ^^^ |
|