| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| In zebrafish , expression of the clock gene Period 3 ( Per 3 ) oscillates throughout embryogenesis in the central nervous system and the retina . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| The basic helix loop helix PAS proteins CLOCK and BMAL 1 are positive regulators and drive the expression of the negative regulators CRY 1 and CRY 2 , as well as PER 1 , PER 2 , and PER 3 . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| Among three period genes ( per 1 , per 2 , per 3 ) in mammals , only per 2 gene was shown to be involved in the core clock mechanism . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| We analyzed the human period 3 ( hPer 3 ) gene , one of the human homologs of the Drosophila clock gene period ( Per ) , as a possible candidate for rhythm disorder susceptibility . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| Avian homologues of mammalian clock genes Per 2 , Per 3 , Clock , bmal 1 , and MOP 4 have been cloned . ^^^ |
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| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| Recent reports demonstrate that mammalian orthologs ( Per 1 , Per 2 , and Per 3 ) of the Drosophila clock gene Period are expressed in the SCN , PVN , and peripheral tissues . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| We have found that in rat heart all mammalian homologues of known Drosophila clock genes ( bmal 1 , clock , cry 1 , cry 2 , per 1 , per 2 , per 3 , dbp , hlf , and tef ) show circadian patterns of expression and that the induction of clock output genes ( the PAR [ rich in proline and acidic amino acid residues ] transcription factors dbp , hlf , and tef ) is attenuated in the pressure overloaded hypertrophied heart . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| The circadian patterns of gene expression of seven components of the mammalian clock ( bmal 1 , clock , cry 1 , cry 2 , per 1 , per 2 and per 3 ) , as well as three clock output genes ( dbp , hlf and tef ) , were compared in hearts isolated from control and STZ induced diabetic rats . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| The expression of per 3 , cry 1 , 2 , clock , npas 2 , bmal 1 , and casein kinase 1epsilon did not change with sleep deprivation . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| We here report the expression pattern of Period ( Per ) 1 , Per 2 , Per 3 , Cryptochrome ( Cry ) 1 , Cry 2 , Bmal 1 and Clock genes in the SCN of Syrian hamsters when kept under long ( LP ) and short ( SP ) photoperiods . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| A circadian oscillator involving the clock genes Per 3 and Rev erb alpha was identified during early development in zebrafish ( Science 289 ( 2000 ) 297 ) . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| A length polymorphism in the circadian clock gene Per 3 is linked to delayed sleep phase syndrome and extreme diurnal preference . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| On the basis of studies derived from 3 human subjects under controlled conditions , circadian clock genes hPer 1 , hPer 2 , hPer 3 , and hDec 1 are expressed in a circadian manner in human peripheral blood mononuclear cells ( PBMCs ) , with the peak level occurring during the habitual time of activity . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| The endogenous oscillation machinery involves interactive positive and negative transcriptional and posttranslational feedback loops involving the clock genes Per 1 , Per 2 , Per 3 , Clock , Bmal 1 , Cry 1 and Cry 2 . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| Advances in chronobiology have identified the suprachiasmatic nucleus ( SCN ) as the center of biological rhythms and the area in which clock genes such as PER 1 , PER 2 , PER 3 , CLOCK , BMAL 1 , TIM , CRY 1 , CRY 2 , tau act to generate and coordinate biological rhythms . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| Per1 , Per 3 , Cry 2 and Cry 1 clock genes are expressed in the pineal gland and their transcription is increased during the night . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| We cloned human clock genes , including per 1 , per 2 , per 3 , cry 2 and clock , and evaluated their circadian mRNA expression profiles in WI 38 fibroblasts stimulated with serum . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| In Syrian hamsters ( Mesocricetus auratus ) , cells in a subregion of the caudal SCN marked by calbindin D ( 28K ) ( CalB ) express light induced , but not rhythmic , clock genes ( Per 1 , Per 2 , and Per 3 ) . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| This group includes putative clock elements cry 1 and per 3 in addition to several previously unidentified and uninvestigated genes exhibiting profiles of mRNA abundance that varied markedly under daily and constant conditions . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| In summary , per 3 luc zebrafish has revealed complex interactions among developmental events , light , and temperature in the expression of a clock gene . . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| For this purpose , the 24 h expression of nine clock genes ( bmal 1 , clock , per 1 , per 2 , per 3 , cry 1 , cry 2 , dec 1 and dec 2 ) and the aa nat gene was monitored under light dark 8 : 16 and light dark 16 : 8 in the rat pineal by using real time RT PCR . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| Additionally , expressions of Per 1 , Per 2 , Per 3 , Bmal 1 , Bmal 2 , Clock , Cry 1 , and Cry 2 clock genes were simultaneously detected in single chicken pineal glands . . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| The peak phase of Per 1 , Per 2 , and Per 3 appeared in the early morning , whereas that of Bmal 1 and Clock appeared in the midnight hours . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| Recent papers demonstrated strong expression of clock genes such as Per 1 , Per 2 and Per 3 in the SCN . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| For this purpose , the 24 h profiles of nine clock genes ( bmal 1 , clock , per 1 , per 2 , per 3 , dec 1 , dec 2 , cry 1 and cry 2 ) and the arylalkylamine N acetyltransferase gene as an indicator of the circadian pacemaker output were compared between light dark periods of 8 : 16 and 16 : 8 h . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| We have assessed evidence for linkage and association involving polymorphisms in 10 circadian clock genes ( ARNTL , CLOCK , CRY 2 , CSNK1epsilon , DBP , GSK3beta , NPAS 2 , PER 1 , PER 2 , and PER 3 ) to BPAD . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| Three mammalian Period ( Per ) genes , termed Per 1 , Per 2 , and Per 3 , have been identified as structural homologues of the Drosophila circadian clock gene , period ( per ) . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| To investigate avian clock gene expression , partial cDNA sequences of six mammalian clock gene homologs ( Bmal 1 , Clock , Per 2 , Per 3 , Cry 1 , and Cry 2 ) and a novel avian cryptochrome gene ( Cry 4 ) were cloned from the house sparrow , a model system in circadian research . ^^^ |
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| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| For instance , a point mutation in a human clock gene ( Per 2 ) was shown to produce the rare advanced sleep phase syndrome , whereas a functional polymorphism in Per 3 is associated with the more frequent delayed sleep phase syndrome . ^^^ |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15516 and P56645 |
Pubmed |
SVM Score :0.0 |
| NA |
|