| Interacting proteins: O15503 and P04035 |
Pubmed |
SVM Score :0.0 |
| Accelerated degradation of HMG CoA reductase mediated by binding of insig 1 to its sterol sensing domain . ^^^ Here , we show that degradation of HMG CoA reductase is accelerated by the sterol induced binding of its sterol sensing domain to the ER protein insig 1 . ^^^ Whereas insig 1 binding to SCAP leads to ER retention , insig 1 binding to HMG CoA reductase leads to accelerated degradation that is blocked by proteasome inhibitors . ^^^ Insig 1 appears to play an essential role in the sterol mediated trafficking of two proteins with sterol sensing domains , HMG CoA reductase and SCAP . . ^^^ |
|
| Interacting proteins: O15503 and P04035 |
Pubmed |
SVM Score :0.0 |
| The membranous nature of Insig 1 is consistent with its sterol dependent binding to hydrophobic sterol sensing domains in SCAP and HMG CoA reductase . . ^^^ |
|
| Interacting proteins: O15503 and P04035 |
Pubmed |
SVM Score :0.0 |
| Isolation of mutant cells lacking Insig 1 through selection with SR 12813 , an agent that stimulates degradation of 3 hydroxy 3 methylglutaryl coenzyme A reductase . ^^^ Insig 1 and Insig 2 are membrane proteins of the endoplasmic reticulum that regulate lipid metabolism by the following two actions : 1 ) sterol induced binding to 3 hydroxy 3 methylglutaryl coenzyme A reductase , an action that leads to ubiquitination and degradation of the enzyme ; and 2 ) sterol induced binding to SREBP cleavage activating protein , an action that blocks the proteolytic processing of sterol regulatory element binding proteins ( SREBPs ) , membrane bound transcription factors that enhance the synthesis of cholesterol and fatty acids . ^^^ |
|
| Interacting proteins: O15503 and P04035 |
Pubmed |
SVM Score :0.0 |
| Insig 1 and Insig 2 , a pair of endoplasmic reticulum ( ER ) membrane proteins , mediate feedback control of cholesterol synthesis through their sterol dependent binding to the following two polytopic ER membrane proteins : sterol regulatory element binding protein ( SREBP ) cleavage activating protein ( SCAP ) and 3 hydroxy 3 methylglutaryl coenzyme A reductase . ^^^ |
|
| Interacting proteins: O15503 and P04035 |
Pubmed |
SVM Score :0.0 |
| Gp 78 , a membrane anchored ubiquitin ligase , associates with Insig 1 and couples sterol regulated ubiquitination to degradation of HMG CoA reductase . ^^^ |
|
| Interacting proteins: O15503 and P04035 |
Pubmed |
SVM Score :0.0 |
| Insig 1 and Insig 2 are regulatory proteins that restrict the cholesterol biosynthetic pathway by preventing proteolytic activation of SREBPs and by enhancing degradation of HMG CoA reductase . ^^^ |
|
| Interacting proteins: O15503 and P04035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04035 and O15503 |
Pubmed |
SVM Score :0.0 |
| Isolation of mutant cells lacking Insig 1 through selection with SR 12813 , an agent that stimulates degradation of 3 hydroxy 3 methylglutaryl coenzyme A reductase . ^^^ Insig 1 and Insig 2 are membrane proteins of the endoplasmic reticulum that regulate lipid metabolism by the following two actions : 1 ) sterol induced binding to 3 hydroxy 3 methylglutaryl coenzyme A reductase , an action that leads to ubiquitination and degradation of the enzyme ; and 2 ) sterol induced binding to SREBP cleavage activating protein , an action that blocks the proteolytic processing of sterol regulatory element binding proteins ( SREBPs ) , membrane bound transcription factors that enhance the synthesis of cholesterol and fatty acids . ^^^ |
|
| Interacting proteins: P04035 and O15503 |
Pubmed |
SVM Score :0.0 |
| Insig 1 and Insig 2 , a pair of endoplasmic reticulum ( ER ) membrane proteins , mediate feedback control of cholesterol synthesis through their sterol dependent binding to the following two polytopic ER membrane proteins : sterol regulatory element binding protein ( SREBP ) cleavage activating protein ( SCAP ) and 3 hydroxy 3 methylglutaryl coenzyme A reductase . ^^^ |
|
| Interacting proteins: P04035 and O15503 |
Pubmed |
SVM Score :0.0 |
| Accelerated degradation of HMG CoA reductase mediated by binding of insig 1 to its sterol sensing domain . ^^^ Here , we show that degradation of HMG CoA reductase is accelerated by the sterol induced binding of its sterol sensing domain to the ER protein insig 1 . ^^^ Whereas insig 1 binding to SCAP leads to ER retention , insig 1 binding to HMG CoA reductase leads to accelerated degradation that is blocked by proteasome inhibitors . ^^^ Insig 1 appears to play an essential role in the sterol mediated trafficking of two proteins with sterol sensing domains , HMG CoA reductase and SCAP . . ^^^ |
|
| Interacting proteins: P04035 and O15503 |
Pubmed |
SVM Score :0.0 |
| The membranous nature of Insig 1 is consistent with its sterol dependent binding to hydrophobic sterol sensing domains in SCAP and HMG CoA reductase . . ^^^ |
|
| Interacting proteins: P04035 and O15503 |
Pubmed |
SVM Score :0.0 |
| Gp 78 , a membrane anchored ubiquitin ligase , associates with Insig 1 and couples sterol regulated ubiquitination to degradation of HMG CoA reductase . ^^^ |
|
| Interacting proteins: P04035 and O15503 |
Pubmed |
SVM Score :0.0 |
| Insig 1 and Insig 2 are regulatory proteins that restrict the cholesterol biosynthetic pathway by preventing proteolytic activation of SREBPs and by enhancing degradation of HMG CoA reductase . ^^^ |
|
| Interacting proteins: P04035 and O15503 |
Pubmed |
SVM Score :0.0 |
| NA |
|