| Interacting proteins: O15492 and P00533 |
Pubmed |
SVM Score :0.0 |
| RGS 16 underwent phosphorylation in response to m 2 muscarinic receptor or EGFR stimulation in HEK 293T or COS 7 cells , which required EGFR kinase activity . ^^^ RGS 16 co immunoprecipitated with EGFR , and the interaction did not require EGFR activation . ^^^ Purified EGFR phosphorylated only recombinant RGS 16 wild type or Y177F in vitro , implying that EGFR mediated phosphorylation depended on residue Tyr ( 168 ) . ^^^ These data suggest that tyrosine phosphorylation regulates RGS 16 function and that EGFR may potentially inhibit Galpha ( 1 ) dependent MAPK activation in a feedback loop by enhancing RGS 16 activity through tyrosine phosphorylation . . ^^^ RGS 16 function is regulated by epidermal growth factor receptor mediated tyrosine phosphorylation . ^^^ |
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| Interacting proteins: O15492 and P00533 |
Pubmed |
SVM Score :0.0 |
| In addition , p 60 Src or Lyn kinase phosphorylated recombinant RGS 16 in vitro , and RGS 16 underwent phosphorylation in the presence of constitutively active Src ( Y529F ) in EGFR ( ) CHO K 1 cells . ^^^ |
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