| Interacting proteins: O15467 and P32246 |
Pubmed |
SVM Score :0.69259695 |
| Human CC chemokine liver expressed chemokine / CCL16 is a functional ligand for CCR 1 , CCR 2 and CCR 5 , and constitutively expressed by hepatocytes . 0.69259695^^^ |
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| Interacting proteins: O15467 and P32246 |
Pubmed |
SVM Score :1.1520466 |
| We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR 1 and CCR 8 transfected HEK 293 cells . 1.1520466^^^ LEC induces chemotaxis and adhesion by interacting with CCR 1 and CCR 8 . 0.87388354^^^ |
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| Interacting proteins: O15467 and P32246 |
Pubmed |
SVM Score :0.95982987 |
| LEC has been shown to chemoattract monocytes , lymphocytes , and polymorphonuclear leukocytes ( PMNs ) by its binding to CCR 1 and CCR 8 chemokine receptors . 0.95982987^^^ |
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| Interacting proteins: O15467 and P32246 |
Pubmed |
SVM Score :0.0 |
| Here we report that CCL 16 activates an angiogenic program in vascular endothelial cells by activating CCR 1 . ^^^ BX 471 ( R N [ 5 chloro 2 [ 2 [ 4 ( 4 fluorophenyl ) methyl ] 2 methyl 1 piperazinyl ] 2 oxoethoxy ] phenyl ] urea hydrochloric acid salt ) , a CCR 1 antagonist , inhibits angiogenic properties of CCL 16 , whereas blocking of CCR 8 or desensitizing CCR 2 , which are both well known receptors for CCL 16 , did not abolish endothelial activation . ^^^ CCL 16 may be specifically cross linked to CCR 1 expressed on endothelial cells . ^^^ |
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| Interacting proteins: O15467 and P32246 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The result of cDNA array showed that one chemotactic related gene was up regulated more than two fold ( RANTES ) and seven chemotactic related genes were down regulated more than two fold ( CCR 1 , CCR 5 , ccl 16 , GRObeta , GROgamma , IL 8 and granulocyte chemotactic protein 2 ) in MCP 1 treated U 937 cells at mRNA level . ^^^ |
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| Interacting proteins: O15467 and P32246 |
Pubmed |
SVM Score :0.0 |
| We propose that IL 10 modulates the effects of CCL 16 on monocytes by increasing their CCR 1 dependent response . ^^^ |
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| Interacting proteins: O15467 and P32246 |
Pubmed |
SVM Score :0.0 |
| Differential CCR 1 mediated chemotaxis signaling induced by human CC chemokine HCC 4 / CCL16 in HOS cells . ^^^ Human osteogenic sarcoma cells stably expressing CCR 1 were used to investigate HCC 4 mediated chemotaxis signaling events via CCR 1 . ^^^ The chemotactic activity of HCC 4 as well as those of other CCR 1 dependent chemokines including MIP 1alpha / CCL3 , RANTES / CCL5 , and Lkn 1 / CCL15 was inhibited by the treatment of pertussis toxin , an inhibitor of Gi / Go protein , U 73122 , an inhibitor of phospholipase C ( PLC ) , and rottlerin , a specific inhibitor of protein kinase Cdelta ( PKCdelta ) . ^^^ SB 202190 , an inhibitor of p 38 mitogen activated protein kinase , only blocked the chemotactic activity of HCC 4 , but not those of other CCR 1 dependent chemokines . ^^^ HCC 4 induced no intracellular Ca2+ flux in contrast to other CCR 1 dependent chemokines . ^^^ |
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| Interacting proteins: O15467 and P32246 |
Pubmed |
SVM Score :0.0 |
| NA |
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