| Interacting proteins: O15409 and Q9H334 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15409 and Q9H334 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15409 and Q9H334 |
Pubmed |
SVM Score :0.57705454 |
| Screening for proteins that interact with subdomains 1 and 2 of Foxp 2 using yeast two hybrid analysis revealed that subdomain 2 binds to C terminal binding protein 1 , which can synergistically repress transcription with Foxp 1 and Foxp 2 , but not Foxp 4 . 0.57705454^^^ |
|
| Interacting proteins: O15409 and Q9H334 |
Pubmed |
SVM Score :0.0 |
| To elucidate the anatomical basis of language processing in the brain , we have examined the expression pattern of Foxp 2 gene and its homologous gene , Foxp 1 , in the rat brain through development . ^^^ In contrast to Foxp 2 , Foxp 1 was expressed in both the striosomal and matrix compartments in the striatum through development . ^^^ |
|
| Interacting proteins: O15409 and Q9H334 |
Pubmed |
SVM Score :0.0 |
| In this report , we have identified and characterized two members of this Fox gene family , Foxp 1 and Foxp 2 , and show that they comprise a new subfamily of Fox genes expressed in the lung . ^^^ Foxp 1 and Foxp 2 are expressed at high levels in the lung as early as E12 . 5 of mouse development with Foxp 2 expression restricted to the airway epithelium . ^^^ In addition , Foxp 1 and Foxp 2 are expressed at lower levels in neural , intestinal , and cardiovascular tissues during development . ^^^ Upon differentiation of the airway epithelium along the proximal distal axis , Foxp 2 expression becomes restricted to the distal alveolar epithelium whereas Foxp 1 expression is observed in the distal epithelium and mesenchyme . ^^^ Foxp 1 and Foxp 2 can regulate epithelial lung gene transcription as was demonstrated by their ability to dramatically repress the mouse CC 10 promoter and , to a lesser extent , the human surfactant protein C promoter . ^^^ |
|
| Interacting proteins: O15409 and Q9H334 |
Pubmed |
SVM Score :0.0 |
| Foxp 4 : a novel member of the Foxp subfamily of winged helix genes co expressed with Foxp 1 and Foxp 2 in pulmonary and gut tissues . ^^^ The full length mouse Foxp 4 cDNA encodes a 685 amino acid protein that is similar to Foxp 1 and Foxp 2 . ^^^ To compare the protein expression patterns of Foxp 4 to Foxp 1 and Foxp 2 , specific polyclonal antisera to each of these proteins was used in immunohistochemical analysis of mouse embryonic tissues . ^^^ All three proteins are expressed in lung epithelium with Foxp 1 and Foxp 4 expressed in both proximal and distal airway epithelium while Foxp 2 is expressed primarily in distal epithelium . ^^^ At embryonic day 12 . 5 , Foxp 1 and Foxp 2 are expressed in both the mucosal and epithelial layers of the intestine . ^^^ |
|
| Interacting proteins: O15409 and Q9H334 |
Pubmed |
SVM Score :0.0 |
| Characterization of Foxp 2 and Foxp 1 mRNA and protein in the developing and mature brain . ^^^ Foxp 2 and Foxp 1 are recently identified members of the Fox family of winged helix / forkhead transcription factor genes . ^^^ Since Foxp 2 appears to be important in language , we wanted to explore the expression of this gene and a homologous gene , Foxp 1 , in the developing brain . ^^^ In the present study , we investigated the time course and localization of Foxp 2 and Foxp 1 mRNA and protein expression in the developing and adult mouse using in situ hybridization and immunohistochemistry . ^^^ Foxp 2 and Foxp 1 are expressed as early as E12 . 5 and persist into adulthood . ^^^ |
|
| Interacting proteins: O15409 and Q9H334 |
Pubmed |
SVM Score :0.0 |
| Parallel FoxP 1 and FoxP 2 expression in songbird and human brain predicts functional interaction . ^^^ Here , in situ hybridization analyses for FoxP 1 and FoxP 2 in a songbird reveal a corticostriatal expression pattern congruent with the abnormalities in brain structures of affected KE family members . ^^^ The overlap in FoxP 1 and FoxP 2 expression observed in the songbird suggests that combinatorial regulation by these molecules during neural development and within vocal control structures may occur . ^^^ In support of this idea , we find that FOXP 1 and FOXP 2 expression patterns in human fetal brain are strikingly similar to those in the songbird , including localization to subcortical structures that function in sensorimotor integration and the control of skilled , coordinated movement . ^^^ The specific colocalization of FoxP 1 and FoxP 2 found in several structures in the bird and human brain predicts that mutations in FOXP 1 could also be related to speech disorders . . ^^^ |
|
| Interacting proteins: O15409 and Q9H334 |
Pubmed |
SVM Score :0.0 |
| To test whether the expression pattern of FOXP 2 is consistent with a role in learned vocal communication , we cloned zebra finch FoxP 2 and its close relative FoxP 1 and compared mRNA and protein distribution in developing and adult brains of a variety of avian vocal learners and non learners , and a crocodile . ^^^ |
|
| Interacting proteins: O15409 and Q9H334 |
Pubmed |
SVM Score :0.0 |
| We have studied FoxP 2 in avian vocal learners and non learners and review evidence that links both the molecule and its close homologue FoxP 1 to the development of brain regions implicated in vocal learning and to their function . ^^^ |
|
| Interacting proteins: O15409 and Q9H334 |
Pubmed |
SVM Score :0.0 |
| First , the specificity of our FOXP 1 monoclonal antibody was verified by confirming that it did not recognize the closely related FOXP 2 , FOXP 3 , or FOXP 4 proteins . ^^^ |
|
| Interacting proteins: O15409 and Q9H334 |
Pubmed |
SVM Score :0.0 |
| Here , we show that , among the Foxp transcriptional factor family , which includes Foxp 1 , Foxp 2 , and Foxp 3 , only Foxp 3 has the ability to inhibit IL 2 , IL 4 , and IFN gamma production by primary T helper cells . ^^^ |
|
| Interacting proteins: Q9H334 and O15409 |
Pubmed |
SVM Score :0.57705454 |
| Screening for proteins that interact with subdomains 1 and 2 of Foxp 2 using yeast two hybrid analysis revealed that subdomain 2 binds to C terminal binding protein 1 , which can synergistically repress transcription with Foxp 1 and Foxp 2 , but not Foxp 4 . 0.57705454^^^ |
|
| Interacting proteins: Q9H334 and O15409 |
Pubmed |
SVM Score :0.0 |
| In this report , we have identified and characterized two members of this Fox gene family , Foxp 1 and Foxp 2 , and show that they comprise a new subfamily of Fox genes expressed in the lung . ^^^ Foxp 1 and Foxp 2 are expressed at high levels in the lung as early as E12 . 5 of mouse development with Foxp 2 expression restricted to the airway epithelium . ^^^ In addition , Foxp 1 and Foxp 2 are expressed at lower levels in neural , intestinal , and cardiovascular tissues during development . ^^^ Upon differentiation of the airway epithelium along the proximal distal axis , Foxp 2 expression becomes restricted to the distal alveolar epithelium whereas Foxp 1 expression is observed in the distal epithelium and mesenchyme . ^^^ Foxp 1 and Foxp 2 can regulate epithelial lung gene transcription as was demonstrated by their ability to dramatically repress the mouse CC 10 promoter and , to a lesser extent , the human surfactant protein C promoter . ^^^ |
|
| Interacting proteins: Q9H334 and O15409 |
Pubmed |
SVM Score :0.0 |
| Foxp 4 : a novel member of the Foxp subfamily of winged helix genes co expressed with Foxp 1 and Foxp 2 in pulmonary and gut tissues . ^^^ The full length mouse Foxp 4 cDNA encodes a 685 amino acid protein that is similar to Foxp 1 and Foxp 2 . ^^^ To compare the protein expression patterns of Foxp 4 to Foxp 1 and Foxp 2 , specific polyclonal antisera to each of these proteins was used in immunohistochemical analysis of mouse embryonic tissues . ^^^ All three proteins are expressed in lung epithelium with Foxp 1 and Foxp 4 expressed in both proximal and distal airway epithelium while Foxp 2 is expressed primarily in distal epithelium . ^^^ At embryonic day 12 . 5 , Foxp 1 and Foxp 2 are expressed in both the mucosal and epithelial layers of the intestine . ^^^ |
|
| Interacting proteins: Q9H334 and O15409 |
Pubmed |
SVM Score :0.0 |
| Characterization of Foxp 2 and Foxp 1 mRNA and protein in the developing and mature brain . ^^^ Foxp 2 and Foxp 1 are recently identified members of the Fox family of winged helix / forkhead transcription factor genes . ^^^ Since Foxp 2 appears to be important in language , we wanted to explore the expression of this gene and a homologous gene , Foxp 1 , in the developing brain . ^^^ In the present study , we investigated the time course and localization of Foxp 2 and Foxp 1 mRNA and protein expression in the developing and adult mouse using in situ hybridization and immunohistochemistry . ^^^ Foxp 2 and Foxp 1 are expressed as early as E12 . 5 and persist into adulthood . ^^^ |
|
| Interacting proteins: Q9H334 and O15409 |
Pubmed |
SVM Score :0.0 |
| To elucidate the anatomical basis of language processing in the brain , we have examined the expression pattern of Foxp 2 gene and its homologous gene , Foxp 1 , in the rat brain through development . ^^^ In contrast to Foxp 2 , Foxp 1 was expressed in both the striosomal and matrix compartments in the striatum through development . ^^^ |
|
| Interacting proteins: Q9H334 and O15409 |
Pubmed |
SVM Score :0.0 |
| Parallel FoxP 1 and FoxP 2 expression in songbird and human brain predicts functional interaction . ^^^ Here , in situ hybridization analyses for FoxP 1 and FoxP 2 in a songbird reveal a corticostriatal expression pattern congruent with the abnormalities in brain structures of affected KE family members . ^^^ The overlap in FoxP 1 and FoxP 2 expression observed in the songbird suggests that combinatorial regulation by these molecules during neural development and within vocal control structures may occur . ^^^ In support of this idea , we find that FOXP 1 and FOXP 2 expression patterns in human fetal brain are strikingly similar to those in the songbird , including localization to subcortical structures that function in sensorimotor integration and the control of skilled , coordinated movement . ^^^ The specific colocalization of FoxP 1 and FoxP 2 found in several structures in the bird and human brain predicts that mutations in FOXP 1 could also be related to speech disorders . . ^^^ |
|
| Interacting proteins: Q9H334 and O15409 |
Pubmed |
SVM Score :0.0 |
| To test whether the expression pattern of FOXP 2 is consistent with a role in learned vocal communication , we cloned zebra finch FoxP 2 and its close relative FoxP 1 and compared mRNA and protein distribution in developing and adult brains of a variety of avian vocal learners and non learners , and a crocodile . ^^^ |
|
| Interacting proteins: Q9H334 and O15409 |
Pubmed |
SVM Score :0.0 |
| We have studied FoxP 2 in avian vocal learners and non learners and review evidence that links both the molecule and its close homologue FoxP 1 to the development of brain regions implicated in vocal learning and to their function . ^^^ |
|
| Interacting proteins: Q9H334 and O15409 |
Pubmed |
SVM Score :0.0 |
| First , the specificity of our FOXP 1 monoclonal antibody was verified by confirming that it did not recognize the closely related FOXP 2 , FOXP 3 , or FOXP 4 proteins . ^^^ |
|
| Interacting proteins: Q9H334 and O15409 |
Pubmed |
SVM Score :0.0 |
| Here , we show that , among the Foxp transcriptional factor family , which includes Foxp 1 , Foxp 2 , and Foxp 3 , only Foxp 3 has the ability to inhibit IL 2 , IL 4 , and IFN gamma production by primary T helper cells . ^^^ |
|
| Interacting proteins: Q9H334 and O15409 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9H334 and O15409 |
Pubmed |
SVM Score :0.0 |
| NA |
|