| Interacting proteins: O15400 and Q9UNK0 |
Pubmed |
SVM Score :0.0 |
| Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking . ^^^ |
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| Interacting proteins: O15400 and Q9UNK0 |
Pubmed |
SVM Score :0.0 |
| We report that syntaxin 7 , syntaxin 8 , vti1b and endobrevin / VAMP 8 form a complex that functions in the fusion of late endosomes . ^^^ Substitution experiments , sequence and structural comparisons revealed that each protein occupies a unique position in the complex , with syntaxin 7 corresponding to syntaxin 1 , and vti1b and syntaxin 8 corresponding to the N and C terminal domains of SNAP 25 , respectively . ^^^ |
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| Interacting proteins: O15400 and Q9UNK0 |
Pubmed |
SVM Score :0.0 |
| Here we report the 1 . 9 A resolution crystal structure of an endosomal SNARE core complex containing four SNAREs : syntaxin 7 , syntaxin 8 , vti1b and endobrevin / VAMP 8 . ^^^ |
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| Interacting proteins: O15400 and Q9UNK0 |
Pubmed |
SVM Score :0.0 |
| The SNAREs syntaxin 7 , syntaxin 8 , vti1b , and endobrevin / VAMP8 function in the fusion of late endosomes . ^^^ Here we show that the N terminal regions of syntaxin 7 , syntaxin 8 , and vti1b contain well folded alpha helical domains . ^^^ Only syntaxin 7 adopts a closed conformation , whereas in vti1b and syntaxin 8 , the N terminal domains do not interact with the adjacent SNARE motifs . ^^^ Accordingly , the rate of SNARE complex assembly is retarded about 7 fold when syntaxin 7 contains its N terminal domain , whereas the N terminal domains of vti1b and syntaxin 8 have no influence on assembly kinetics . ^^^ |
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| Interacting proteins: O15400 and Q9UNK0 |
Pubmed |
SVM Score :0.0 |
| Syntaxin 7 , syntaxin 8 , Vti 1 and VAMP 7 ( vesicle associated membrane protein 7 ) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum . ^^^ The syntaxin 7 complex contains two co t SNAREs [ Vti 1 ( Vps10p tail interactor 1 ) and syntaxin 8 ] and a 5 SNARE [ VAMP 7 ( vesicle associated membrane protein 7 ) ] ( where t SNAREs are SNAREs of the target compartment and 5 SNAREs are SNAREs present in donor vesicles ) . ^^^ In endosomes and in vitro , syntaxin 7 , Vti 1 and syntaxin 8 form a complex that is able to bind VAMP 7 . ^^^ The lysosomal content of syntaxin 7 , Vti 1 , syntaxin 8 and VAMP 7 is low compared with that in endosomes , implying a highly active recycling or retention mechanism . ^^^ A likely model is that VAMP 7 is a 5 SNARE present on vesicles carrying lysosomal enzymes , and that the syntaxin 7 Vti 1 syntaxin 8 t SNARE complex is associated with incoming endocytic material . . ^^^ |
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| Interacting proteins: O15400 and Q9UNK0 |
Pubmed |
SVM Score :0.0 |
| A SNARE complex consisting of vti1b , syntaxin 8 , syntaxin 7 , and endobrevin / VAMP 8 which is required for fusion of late endosomes in vitro has been identified recently . ^^^ Here , we generated mice deficient in vti1b to study the function of this protein in vivo . vti1b deficient mice had reduced amounts of syntaxin 8 due to degradation of the syntaxin 8 protein , while the amounts of syntaxin 7 and endobrevin did not change . ^^^ |
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| Interacting proteins: O15400 and Q9UNK0 |
Pubmed |
SVM Score :0.0 |
| A trans SNARE complex consisting of Q SNAREs syntaxin 7 , Vti1b and syntaxin 8 and the R SNARE VAMP 8 has been shown by others to be responsible for homotypic fusion of late endosomes . ^^^ |
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