Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Immunological detection of the NMDAR 1 glutamate receptor subunit expressed in embryonic kidney 293 cells and in rat brain . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Upon expression in cultured cells , the new subunits yielded prominent , typical glutamate and NMDA activated currents only when they were in heteromeric configurations with NR 1 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The half maximal response ( ED 50 ) value of NAAG on expressed NMDAR 1 was 185 microM , which shows that NAAG is about 115 times less potent than L glutamate ( Glu ) , the ED 50 of which value was 1 . 6 microM . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Thus , we examined immunocytochemically the distribution of the common NMDAR 1 glutamate receptor subunit to evaluate further the potential sites of glutamatergic action . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Expression of the gene coding for the NR 1 subunit of the N methyl D aspartate ( NMDA ) type of glutamate receptor was investigated in the developing rat brain . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Expression of the NR 1 subunit in Xenopus oocytes produces channels that respond to glutamate and are blocked by competitive and noncompetitive antagonists of the N methyl D aspartate ( NMDA ) receptor . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Nitric oxide ( NO ) , an important neuromessenger , and the glutamate receptor subtype , NMDA NR 1 , have been implicated in nociception in the STN . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The order of affinity for [ 3H ] glutamate was NR 1 NR2B > NR 1 NR2A approximately NR 1 NR2D > NR 1 NR2C > NR 1 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Antibodies to the NMDAR 1 glutamate receptor subunit and the GluR 1 and GluR2 / 3 subunits of the AMPA glutamate receptor were used to localize these receptor components in the basolateral amygdala ( ABL ) of the rat and monkey . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Because N methyl D aspartate ( NMDA ) glutamate ionotropic receptors are involved in the occurrence of audiogenic seizures , we investigated by in situ hybridization methods , the expression of the different subunits ( NR 1 , NR2A , NR2B , NR2C ) of this receptor in the central nucleus of the inferior colliculus ( IC ) , a main relay of the auditory pathways . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In order to characterize the neurochemical profile of these neoplastic and malformative glioneuronal lesions , we have examined the presence of the alpha 1 subunit of the GABAA receptor , the N methyl D aspartate receptor subunit 1 ( NR 1 ) , glutamate decarboxylase , tyrosine hydroxylase , somatostatin , parvalbumin , and calretinin in 60 gangliogliomas , 11 DNT , 10 tuberous sclerosis like lesions and 17 non tuberous sclerosis like glioneuronal malformations . ^^^ Despite a great variation between and within the different entities , the neurochemical profile was generally reminiscent of normal neocortex : glutamate decarboxylase , GABAA receptor and NR 1 which are common in neocortical neurons were present in the great majority of the lesions and often showed high labeling indices . ^^^ There were three tuberous sclerosis like lesions ( 30 % ) that contained both NR 1 and glutamate decarboxylase immunoreactive giant cells in addition to well differentiated ganglion cells . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Messenger RNA levels for the N methyl D aspartate receptor subunit , NR 1 ; the non N methyl D aspartate receptor subunits , glutamate receptors 3 and 4 ; the high affinity kainate receptor subunits 1 and 2 ; and the GABAA receptor subunits , alpha 2 , beta 2 , gamma 2 were unchanged . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The high evolutionary conservation in the structure and properties of NMDAR 1 argues strongly for the importance of this receptor in functions of glutamate neurotransmission . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Regulation of the expression of NR 1 NMDA glutamate receptor subunits during hippocampal LTP . ^^^ Several isoforms of the NMDA receptor 1 ( NR 1 ) subunits of the ionotropic NMDA ( N methyl D aspartate ) glutamate receptor contain a consensus site for phosphorylation by protein kinase C ( PKC ) which , once phosphorylated results in an increased conductance through the receptor channel . ^^^ The change in the expression of PKC sensitive NR 1 subunits may be the molecular basis for the increased response of the post synaptic cell to released glutamate during the maintenance phase of LTP . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The glutamate receptor channels of the N methyl D aspartate ( NMDA ) subtype are composed of different subunits named NR 1 and NR2A D . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Nine multiplex schizophrenia families were genotyped with polymorphisms for the GLUR 5 and NMDAR 1 glutamate receptor subunit genes . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The immunocytochemical localization of N acetylaspartyl glutamate , its hydrolysing enzyme NAALADase , and the NMDAR 1 receptor at a vertebrate neuromuscular junction . ^^^ Here we describe the immunocytochemical detection at the rat neuromuscular junction of N acetylaspartylglutamate in terminals of motoneurons , of N acetylated alpha linked acidic dipeptidase in perisynaptic Schwann cells , and of the NMDAR 1 glutamate receptor subunit on postsynaptic muscle membranes . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Comparison of intron positions in genes encoding different members of the glutamate receptor family confirms a close evolutionary relationship of the NR2C and NMDAR 1 subunit genes . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The NMDA receptor channel is formed by at least two members of the glutamate receptor ( GluR ) channel subunit families , the GluR epsilon ( NR 2 ) and GluR zeta ( NR 1 ) subunit families . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
High affinity binding to NR 1 transfected cells was not observed with the transmitter recognition site radioligands L [ 3H ] glutamate and D , L ( epsilon ) 2 [ 3H ] amino 4 propyl 5 phosphono 3 pentanoic acid ( [ 3H ] CGP 39653 ) or the ion channel radioligand [ 3H ] dizocilpine ( [ 3H ] MK 801 ) . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The N methyl D aspartate ( NMDA ) NR 1 glutamate receptor subtype has been proposed to play an important role in the transmission of orofacial sensory information in the spinal trigeminal nucleus ( STN ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We have now shown that glutamate enables PII to stimulate the dephosphorylation of NRI phosphate when present in equimolar concentration with NRII . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We have used site directed mutagenesis to study amino acids in the human NR 1 subunit that contribute to the glycine binding site of the NMDA receptor without affecting the agonist site for glutamate . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Fourteen glutamate receptor subunits were studied : GluR 1 4 ( including flip and flop variants ) , GluR 5 7 , KA 1 & 2 , NR 1 , and NR2A D . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We used in situ hybridization to examine the effect of removal of the glutamatergic input to the striatum by unilateral frontal cortical ablation on the expression of genes encoding subunits from three families of glutamate receptors : N methyl D aspartate receptors ( NMDAR 1 , NMDAR2A , and NMDAR2B ) ; alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate ( AMPA ) receptors ( GluR 1 4 , flip and flop splice variants ) ; and metabotropic receptors ( mGluR 1 5 ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NMDA subtypes of glutamate receptors are formed after coexpression of the NR 1 cDNA with a cDNA of the NR 2 family . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Transcript levels of the NMDA receptor genes NMDAR 1 , NR2A , NR2B , NR2C , and NR2D and a glutamate binding protein ( GBP ) were not altered by kindling . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In this study , in situ hybridization techniques were employed to map the distribution of enteric neurons which express mRNA for the glutamate N methyl D aspartate receptor 1 ( NMDAR 1 ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glutamate receptor mRNA for the AMPA subunits GluR 1 , GluR 2 and GluR 4 , and the NMDA receptor subtype NMDAR 1 , were heavily expressed in the SCN and surrounding areas . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
On the basis of sequence similarity and pharmacological properties , the recently cloned glutamate receptor subunits have been assigned as components of NMDA ( NMDAR 1 , 2A D ) , AMPA ( GluR 1 4 ) and KA ( GluR 5 7 , KA 1 , KA 2 ) receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The present study attempted to explore the gene expression of the subunits ( GluR 1 4 ) of the alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid ( AMPA ) type receptor , subunit ( GluR 5 ) of kainic acid ( KA ) type receptor , NR 1 [ a subunit of N methyl D aspartate ( NMDA ) receptors ] and the possible glutamate binding subunit of an NMDA receptor complex in the dorsal horn of the rat spinal cords using in situ hybridization histochemistry . ^^^ Labelling of the dorsal horn neurons by the GluR 5 probe was low , and NR 1 probe and a glutamate binding subunit of an NMDA receptor complex probe labelled them diffusely with low to moderate intensity . ^^^ However , expression of NR 1 and the glutamate binding subunit of an NMDA receptor complex is very strong . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We examined the effects of chronic ethanol exposure on the levels of N methyl D aspartate receptor subunit 1 ( NMDAR 1 ) protein , an essential component of N methyl D aspartate glutamate receptors , in rat brain . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The localization of AMPA receptor subunits ( GluR 1 4 ) , a KA receptor subunit ( GluR 5 ) and NMDA receptor subunits ( NR 1 and NRgbs ; the glutamate binding subunits of an NMDA receptor complex ) was investigated using immunohistochemistry and in situ hybridization histochemistry in the rat dorsal root ganglion . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
With the anti NR 1 A antibody , a 125 kDa protein was discovered that may represent a glutamate receptor not yet characterized . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Comparison with previous studies of localization of other glutamate receptor types revealed that NMDAR 1 may colocalize with these other types in many neurons throughout the nervous system . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
These results demonstrate that alternative splicing of the NR 1 messenger RNA regulates its phosphorylation by PKC , and that mRNA splicing is a novel mechanism for regulating the sensitivity of glutamate receptors to protein phosphorylation . ^^^ These results also provide evidence that the C terminal domain of the NR 1 protein is located intracellularly , suggesting that the proposed transmembrane topology model for glutamate receptors may be incorrect . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The deduced amino acid sequence of DNMDAR 1 displays 46 % amino acid identity to the rat NMDAR 1 polypeptide and shows significant homology ( 16 23 % ) to other vertebrate and invertebrate glutamate receptor proteins . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Alternatively spliced isoforms of the NMDAR 1 glutamate receptor subunit : differential expression in the basal ganglia of the rat . ^^^ Several isoforms of the NMDAR 1 glutamate receptor subunit are produced by alternative mRNA splicing of three cassette sequences . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Sections were immunolabeled with antibodies to the neuronal markers NeuN , glutamate , and calbindin D28k , and to receptors for fibroblast growth factor 2 ( FGFR 1 ) and NMDA ( NMDAR 1 ) and were examined using confocal microscopy . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
After NMDAR 1 antisense ODN injection , striatal binding of 3H glutamate target mRNA signal intensity in the injected striatum . ^^^ After NMDAR 1 antisense ODN injection , striatal binding of 3H glutamate to NMDA sites was not altered , although strychnine insensitive 3H glycine binding sites exhibited a small but significant reduction . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Comparative ultrastructural localization of the NMDAR 1 glutamate receptor in the rat basolateral amygdala and bed nucleus of the stria terminalis . ^^^ Our findings provide the first ultrastructural evidence that glutamate may prominently act through NMDAR 1 receptors to elicit postsynaptic actions on intrinsic neurons in the BLA and BNST . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Drugs of abuse and stress increase the expression of GluR 1 and NMDAR 1 glutamate receptor subunits in the rat ventral tegmental area : common adaptations among cross sensitizing agents . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Histamine and the polyamine agonists spermine and spermidine enhanced glutamate toxicity in a dose dependent manner consistent with expression of an NR 1 NR2B combination of subunits . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Here , the contribution of the M 3 M4 loop of the NR 1 subunit to the binding of glutamate and the co agonist glycine was investigated by site directed mutagenesis . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The N methyl D aspartate ( NMDA ) subtype of ionotropic glutamate receptor is assembled from one NR 1 subunit , expressed in eight splice variants , and four NR 2 subunits ( NR2A D ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In contrast , neither glutamate nor NMDA treatment caused neuronal degeneration in NR 1 / cells , indicating that NMDA receptors are responsible for rapidly triggered glutamate neurotoxicity . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
N methyl D aspartate ( NMDA ) type glutamate receptors are constituted of one obligatory subunit ( NR 1 ) , expressed as eight splice variants , combined with one or more of four NMDAR 2 subunits . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The current through homomeric NMDAR 1 expressed in Xenopus oocytes was increased by 200 500 % by phorbol ester and also by activation of a metabotropic glutamate receptor ( mGluR 1 ) expressed in the same oocytes . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The rank order of potency was quinolinic acid < NMDA < homoquinolinic acid < or = glutamate for the NR 1 + NR2A and NR 1 + NR2B combinations whereas for NR 1 + NR2C it was quinolinic acid < < < < homoquinolinic acid < NMDA < or = glutamate . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Oligonucleotide primers were designed from the previously cloned sequences of the AMPA selective glutamate receptors ( GluR 1 4 ) , KA selective glutamate receptors ( GluR 5 7 , KA 1 & 2 ) , NMDA selective glutamate receptors ( NMDAR 1 & 2 ) , and metabotropic glutamate receptors ( mGluR 1 4 ) . ^^^ The present study suggested that the subunits of GluR 1 4 , GluR 5 , and NMDAR 1 may be assembled into the hetero oligomeric glutamate receptor complex in the VG and that the VG neuron specific stoichiometry of the receptor complex may be functionally significant for the afferent signal transduction in the rat peripheral vestibular system . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We have examined the expression of the NR 1 subunit of the glutamate NMDA receptor and the immediate early gene c jun in lumbar spinal cord following neonatal common peroneal nerve crush . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Homogenates were immunoblotted by using antibodies directed against glutamate transporters ( GLT 1 , GLAST , and EAAC 1 ) and glutamate receptors ( GluR 1 , GluR2 / 3 , GluR6 / 7 , and NMDAR 1 ) , and they were assayed for glutamate transport by D [ 3H ] aspartate binding . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Transiently catecholaminergic cells in the fetal rat express mRNA for the glutamate NMDAR 1 receptor . ^^^ Whether TC cell migration is glutamate mediated remains unclear , since some of them successfully reached the gut without expressing NMDAR 1 message . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In the present study , we used an immunohistochemical double labelling approach to localize ionotropic glutamate receptor subunits ( NMDAR 1 , GluR 1 , GluR2 / 3 , GluR 4 and GluR5 / 6 / 7 ) on specific striatal neuron populations . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Distribution of glutamate receptor subunit proteins GluR 2 ( 4 ) , GluR5 / 6 / 7 , and NMDAR 1 in the canine and primate cerebral cortex : a comparative immunohistochemical analysis . ^^^ The distribution of the AMPA , kainate and NMDA glutamate receptor subunit proteins GluR 2 ( 4 ) , GluR5 / 6 / 7 and NMDAR 1 , respectively , were analyzed in the dog hippocampus and neocortex and compared to macaque monkeys and humans . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The aetiology of ALS is poorly understood , although abnormalities in glutamate and glycine transport have been reported as well as alterations in NMDA receptors including the NR 1 subunit ; suggesting a role for glutamate in the disease process . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The effect of chronic haloperidol treatment on glutamate receptor subunit ( GluR 1 , GluR 2 , KA 1 , KA 2 , NR 1 ) mRNAs and glutamate binding protein mRNA in rat forebrain . ^^^ The mRNAs targetted were the flip and flop isoforms of GluR 1 and GluR 2 , KA 1 and KA 2 , NR 1 , and the glutamate binding protein ( GBP ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
High level expression of the NMDAR 1 glutamate receptor subunit in electroporated COS cells . ^^^ The rat N methyl D aspartate ( NMDA ) glutamate receptor subunit NR 1 1a was transiently expressed in COS cells using the technique of electroporation , which was fivefold more efficient than the calcium phosphate precipitation method of transfection . ^^^ Although immunofluorescent labeling of electroporated COS cells demonstrated that the NR 1 1a protein appears to be associated with the cell membrane , neither NMDA nor glutamate effected an increase in intracellular calcium concentration in fura 2 loaded cells , suggesting that homomeric NR 1 1a receptors do not act as functional ligand gated ion channels . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Alternatively , NMDAR 1 subunit splice variants may differentially respond to interactions with glutamate . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In the NR 1 subunit of the NMDA receptor , mutation of D 732 to glutamate ( D732E ) , asparagine ( D732N ) , alanine ( D732A ) , or glycine ( D732G ) reduced the potency of glycine by > 4000 fold , but these mutations had no effect on sensitivity to glutamate . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
It was found that long term , but not short term , ethanol exposure increased levels of immunoreactivity of the NMDAR 1 subunit , an obligatory component of NMDA glutamate receptors , and of the GluR 1 subunit , a component of many AMPA glutamate receptors ; but at the same time , long term ethanol exposure decreased immunoreactivity levels of the alpha 1 subunit of the GABAA receptor complex . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In this study , the distribution of glutamate receptors was examined with preembedding immunocytochemistry , using 14 antibodies to ionotropic ( GluR 1 , GluR2 / 3 , GluR 4 , GluR 5 7 , GluR6 / 7 , KA 2 , NR 1 , NR2A / B , delta 1 / 2 ) and metabotropic ( mGluR 1 alpha , mGluR2 / 3 , mGluR 5 ) glutamate receptor subtypes . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The expression of NMDA receptor genes ( NR 1 , NR2A B ) was examined by in situ hybridization using oligonucleotide probes , and binding to NMDA receptors assessed using L [ 3H ] glutamate . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To determine whether the perilesional cortex shows evidence for abnormal excitatory or inhibitory neurochemical activity , we immunohistochemically examined the distribution of the alpha 1 subunit of the GABAA receptor ( GABAR ) , the N methyl D aspartate receptor subunit 1 ( NR 1 ) , and glutamate decarboxylase ( GAD ) in 30 surgical specimens of neocortical epilepsy associated lesions . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NMDAR 1 mRNA expression and glutamate receptor stimulated increase in cytosolic calcium concentration in rat and mouse cerebellar granule cells . ^^^ We tested this hypothesis by measuring ( a ) the concentration of mRNA for the obligatory NMDA receptor subunit , NMDAR 1 , and ( b ) the glutamate / NMDA stimulated increase in cytosolic Ca ( 2+ ) ion concentration in cultures at physiological or elevated K ( + ) ion concentration . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The present immunocytochemical study used three specific antibodies to GluR 2 , 4 , GluR 5 , 6 , 7 and to NMDAR 1 to differentiate between the regional distribution of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionic acid ( AMPA ) , kainate and N methyl D aspartate ( NMDA ) subtypes of glutamate receptors throughout the rabbit spinal cord . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In situ hybridisation and immunocytochemical studies reveal the presence of several NMDA ( NMDAR 1 , NMDAR2C ) , non NMDA ( GluR 1 , GluR 2 , GluR 4 ) and metabotropic ( mGluR 1 ) glutamate receptor subunits in the SCN . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Ultrastructural localization of glutamate receptor subunits ( NMDAR 1 , AMPA GluR 1 and GluR2 / 3 ) and spinothalamic tract cells . ^^^ The associations of glutamate receptor subunits ( NMDAR 1 , AMPA GluR 1 and GluR2 / 3 ) and spinothalamic tract neurons in the rat lumbar spinal cord dorsal horn were investigated . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The distribution of ionotropic glutamate receptor subunits GluR 1 and NMDAR 1 , and the inhibitory neurotransmitter gamma aminobutyric acid ( GABA ) was studied by immunocytochemistry , in the monkey amygdala . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glutamate activated currents ( evoked every 20 s for up to 20 min ) were increased by src and fyn kinases without affecting the desensitization and deactivation kinetics in NR 1 NR2A but the kinases had no effects in NR 1 NR2B , NR 1 NR2C and NR 1 NR2D receptor channels , suggesting that a phosphorylation site in NR2A is targeted . 4 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The trafficking and phosphorylation of the NR 1 and NR 2 subunits of the N methyl D aspartate type glutamate receptor complex were studied in cultured rat hippocampal neurons . ^^^ Following stimulation of the cultures with glutamate / glycine or phorbol esters , NR 1 phosphorylation was found to be enhanced by 3 5 fold , whereas phosphorylation of NR 2 subunits was enhanced by less than 2 fold . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Distribution of glutamate receptors in these two synapse populations in rat cerebella was studied using preembedding immunocytochemistry with antibodies to GluR 1 , GluR2 / 3 , GluR 5 7 , NR 1 , delta 1 / 2 , and mGluR 1 alpha . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Changes of NMDA receptor subunit ( NR 1 , NR2B ) and glutamate transporter ( GLT 1 ) mRNA expression in Huntington ' s disease an in situ hybridization study . ^^^ The distribution of NMDA receptor subunit ( NR 1 , NR2B ) and glia bound glutamate transporter ( GLT 1 ) mRNAs was investigated in postmortem brains of Huntington ' s disease ( HD ) patients and controls by means of in situ hybridization using radiolabeled deoxyoligonucleotides . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Homology based molecular modeling of the glutamate and glycine binding domains indicates that the NR 2 and NR 1 subunits use similar residues to ligate the agonists ' alpha aminocarboxylic acid groups , whereas differences in side chain interactions and size of aromatic residues determine ligand selectivity . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The combination of NMDAR 1 and NMDAR 2 in heteromeric configurations potentiates glutamate response and produces a functional variability . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Moreover , findings from this study suggest that a change in NR 1 splicing following a neurological injury could significantly alter glutamate pathogenicity in a particular population of cells . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In addition , we show that stimulation of metabotropic glutamate receptor 1alpha , which potentiates NMDA channels through PKC , decreases the ability of NR 1 to bind to calmodulin . ^^^ Thus , our data provide clues to understanding the basis of cross talk between two types of receptors , metabotropic glutamate receptors and the NR 1 subunit , in NMDA channel potentiation . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
These neurons also express various glutamate receptor subunits including GluR 1 , GluR 4 and NMDAR 1 as detected by immunological methods . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Distribution of glutamate receptors GluR 2 / 3 and NR 1 in the developing rat cerebellum . ^^^ The distribution of glutamate receptors GluR2 / 3 and NR 1 was analysed immunohistochemically during development of the rat cerebellum . ^^^ The developmental appearance of stellate / basket cells and Golgi cells as well as their high reactivity remaining into adulthood suggest that these inhibitory molecular and granular layer interneurons are the principal targets of glutamate axons serving NR 1 synaptic properties while Purkinje cells and brush type granule cells are targets for glutamate connections with GluR2 / 3 characteristics . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We tested the hypothesis that NMDA receptors are necessary for prenatal development of central neural circuits underlying respiratory rhythm generation by comparing the responsiveness of control mice and mutant mice lacking the NMDA receptor R 1 subunit ( NMDAR 1 ) gene to glutamate receptor agonists and antagonists and comparing endogenous respiratory related oscillations generated in vitro by brain stem spinal cord and medullary slice preparations from control and mutant mice . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Such treatment caused an increase in the expression of the NMDAR 1 receptor subunit , 15 % above the levels in the pair fed controls , as well as of three subunits of a complex that has properties characteristic of NMDA receptors , the glutamate , carboxypiperazinylphosphonate , and glycine binding proteins . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glutamate immunoreactive neurons were found in cultured myenteric ganglia , and a subset of enteric neurons expressed NMDA ( NR 1 , NR2A / B ) , AMPA ( GluR 1 , GluR2 / 3 ) , and kainate ( GluR5 / 6 / 7 ) receptor subunits . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The distribution of ionotropic glutamate receptor subunits GluR 1 , GluR2 / 3 and NMDAR 1 , and meta botropic receptor mGluR 1 alpha was studied in the monkey substantia nigra . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The distribution of subunits for the N methyl D aspartate ( NR 1 , NR2A / B ) , alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate ( GluR 1 , GluR2 / 3 , GluR 4 ) and low affinity kainate ( GluR5 / 6 / 7 ) ionotropic glutamate receptors was examined by immunocytochemistry in the temporal cortex and hippocampus of the rhesus macaque ( Macaca mulatta ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To better characterize and distinguish the two entities we examined 25 oligodendrogliomas and 16 DNT immunohistochemically for the presence of the proliferation associated Ki 67 antigen and the following neural antigens : the alpha 1 subunit of the GABAA receptor ( GABAR ) , N methyl D aspartate receptor subunit 1 ( NR 1 ) , glutamate decarboxylase , neuronal nuclei antigen ( NeuN ) , the embryonal form of the neural cell adhesion molecule ( E NCAM ) , synaptophysin , neurofilament protein ( NFP ) , and glial fibrillary acidic protein ( GFAP ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The main findings were as follows : 1 ) AMPA selective GluR2 / 3 and NMDAR 1 share similar distribution patterns in the rat and cat somatosensory thalamus , 2 ) both glutamate receptors are likely to be colocalized at postsynaptic densities of both RL and RS synapses , and 3 ) localization of the glutamate receptor proteins in GABAergic dendrites in the cat thalamus indicates that glutamatergic transmission to GABAergic neurons is also mediated by both NMDA and non NMDA receptors . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Previously it was thought that the binding sites for glycine and glutamate were formed by residues on the NR 1 subunit . ^^^ Therefore we propose that the glutamate binding site is located on NR 2 subunits and ( taking our data together with previous work ) is not on the NR 1 subunit . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glutamate , aspartate , N methyl D aspartate receptor ( NMDAR 1 and 2 subunits ) , and nitric oxide synthase ( NOS ) immunoreactive neurons were studied in the arcuate nucleus ( AN ) of mice treated neonatally with monosodium glutamate ( MSG ) which is known to cause extensive neuronal loss in this hypothalamic nucleus . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NMDAR 1 glutamate receptor subunit isoforms in neostriatal , neocortical , and hippocampal nitric oxide synthase neurons . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Immunocytochemistry with antibodies specific for glutamate receptors GluR 1 , GluR 2 ( 4 ) ( alpha amino 3 hydroxy 5 methylisoxazole 4 propionic acid ) , GluR5 / 6 / 7 ( kainate ) and NR 1 ( N methyl D aspartate ) receptor subunits demonstrated that virtually all projection neurons in all subfields contained subunits from each receptor class . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The median eminence taken from ovariectomized rats was dual immunostained with GnRH and ionotropic glutamate receptor subtypes ( NR 1 , GIuR 1 , GluR2 / 3 , GluR6 / 7 and KA 2 ) , and their colocalization was examined under electron microscopy . ^^^ Of the glutamate receptor subtypes , NR 1 and KA 2 immunoreactivities were colocalized with GnRH immunoreactivity in nerve terminals of the median eminence . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Immunostaining for GluR2 / 3 , NR 1 or NR 2 showed , in both MAM and control animals , that glutamate receptors were mainly concentrated in the soma and dendrites of neocortical and hippocampal pyramidal cells , including in heterotopiae , and in the apical dendrites of hippocampal granule cells . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Here , the numbers of glycine binding NR 1 and glutamate binding NR 2 subunits in the NMDA receptor hetero oligomer were determined by coexpressing the wild type ( wt ) NR 1 with the low affinity mutant NR 1 ( Q387K ) , and the wt NR2B with the low affinity mutant NR2BE387A , subunits in Xenopus oocytes . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In order to understand how specific glutamate receptor genes are involved in the treatment of schizophrenia we have used a multiprobe oligonucleotide solution hybridization ( MOSH ) technique to examine the regulation of gene express of the NMDAR 1 , 2A , 2B , 2C , 2D receptor subunits in the left rat brain following treatment with the optical isomers of flupenthixol . cis and trans flupenthixol are both present in the commonly used oral and depot treatments for schizophrenia and a controlled trial showed that cis flupenthixol had a significantly superior ability to ameliorate the positive symptoms of schizophrenia compared to its trans isomer . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The binding site for the co agonist glycine on N methyl D aspartate ( NMDA ) receptors has been mapped to the NR 1 subunit whereas binding of the principal agonist glutamate is mediated by the NR 2 subunits . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We performed a quantitative electron microscopic analysis of the middle third of the molecular layer in the dentate gyrus of rat , using material processed with postembedding gold labeling for the glutamate receptor subunits GluR 1 , GluR2 / 3 , or NMDAR 1 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
At the postsynaptic level , immunohistochemistry and Western blotting revealed in the suprachiasmatic nuclei of infected rats a selective decrease of the expression of glutamate AMPA GluR2 / 3 and NMDAR 1 receptor subunits that gate retinal afferents . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Immunocytochemistry was used to study the expressions of glutamate receptor subunit proteins for NMDAR2A / B , NMDAR 1 splice variants , and AMPA Glu R2 / 3 in human brain resected for intractable epilepsy associated with cortical dysplasia . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
These glycoproteins , purified by concanavalin A lectin affinity chromatography , showed immunoreactivity in the present study with subunit specific antibodies to glutamate receptors as follows : GP 180 , NMDA receptor subunits NR2A / NR2B ; GP 116 , NMDA receptor NR 1 ( 1a ) ; and GP 110 , pan alpha amino 3 hydroxy 5 methylisoxazole 4 propionate ( pan AMPA ) receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To address whether neuronal activity may differentially regulate the surface expression at synapses of two specific subtypes of ionotropic glutamate receptors we epitope tagged an AMPA ( alpha amino 3 hydroxy 5 methylisoxazole 4 propionic acid ) receptor subunit ( GluR 1 ) and an NMDA ( N methyl D aspartate ) receptor subunit ( NR 1 ) on their extracellular termini and expressed these proteins in cultured hippocampal neurons using recombinant adenoviruses . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Immunocytochemical localization of metabotropic glutamate receptors ( mGluRs ) and ionotropic glutamate receptors ( NMDA type : NMDAR 1 and NMDAR2A C ; AMPA type : GluR 1 4 ) was performed on sections of rat dorsal horn . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
N terminal splice variants of the NMDAR 1 glutamate receptor subunit : differential expression in human and monkey brain . ^^^ The distribution of the mRNA coding for the two N terminal splice variants of the N methyl D aspartate receptor 1 ( NMDAR 1 ) subunit of the glutamate NMDA receptor was studied on whole hemisphere human and macaca fascicularis brain sections by in situ hybridisation . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Immunolabelling for the AMPA glutamate receptor subunits 1 , 2 / 3 , and 4 ( GluR 1 , GluR2 / 3 , and GluR 4 ) and the NMDA receptor subunit 1 ( NR 1 ) was localized predominantly within asymmetrical synapses in both the EP and STN . ^^^ However , at some NR 1 and GluR2 / 3 positive synapses , the level of glutamate immunoreactivity was low in the presynaptic terminal and , in the STN , some of them were GABA immunopositive . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The glycine binding site of this hetero oligomeric ion channel protein is formed by two distinct extracellular regions , S 1 and S 2 , of the NR 1 subunit , whereas the homologous domains of the NR 2 subunit mediate glutamate binding . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Repeated electroconvulsive seizures ( ECS ) induced isoforms of DeltaFosB in frontal cortex , an effect that was associated with increased levels of the NMDA receptor 1 ( NMDAR 1 ) glutamate receptor subunit . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
H ] MDL 105 , 519 binds with equal high affinity to both assembled and unassembled NR 1 subunits of the NMDA receptor . [ 3H ] MDL 105 , 519 ( ( ( E ) 3 ( 2 phenyl 2 carboxyethenyl ) 4 , 6 dichloro 1 [ 3H ] indole 2 ca rboxylic acid ) is a novel radioligand which binds with high affinity , Kd = 2 . 5 nM , to the glycine site of adult rodent forebrain , N methyl D aspartate subtype of glutamate receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
N Methyl D aspartate glutamate receptors ( NMDAR ) form ion channels made up of polypeptides from two classes of subunits ; NR 1 is obligatory for function whereas members of the NR 2 class regulate the properties of the channel . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The association of NMDA receptor subunits and CaMKII was assessed by immunoprecipitating PSD proteins with antibodies specific for NR2A / B and CaMKII : CaMKII coprecipitated with NR2A / B and NR 1 but not with other glutamate ionotropic receptor subunits , such as GluR 1 and GluR 2 3 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Each of these recombinant receptor proteins consisting both of NR 1 and NR 2 subunits also showed a specific binding site for the NMDA agonist glutamate when using L [ 3H ] glutamate as a radioligand . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In this study , immunocytochemistry was used to study the expressions of glutamate receptor subunit proteins for NMDAR2A / B , NMDAR 1 and AMPA Glu R2 / 3 in human brain resected for intractable epilepsy associated with cortical dysplasia . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glutamate receptor subunit GluR 2 and NMDAR 1 immunoreactivity in the retina of macaque monkeys with experimental glaucoma does not identify vulnerable neurons . ^^^ The relationships between the cellular distribution of glutamate receptor subunit proteins GluR 2 and NMDAR 1 and the vulnerability of restricted retinal neuron subpopulations was explored in experimental glaucoma in macaque monkeys , produced by treating the trabecular meshwork in one eye with argon or diode laser burns . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In the present study , the immunohistochemical distribution of alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate ( AMPA ) selective glutamate receptor subunits ( GluR 1 , GluR2 / 3 , GluR 4 ) and the N methyl D aspartate ( NMDA ) receptor subunit NR 1 in the cat caudal brainstem was investigated by using subunit specific antibodies . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Expression of NMDAR 1 , GluR 1 , GluR 7 , and KA 1 glutamate receptor mRNAs is decreased in frontal cortex of `` neuroleptic free ' ' schizophrenics : evidence on reversible up regulation by typical neuroleptics . ^^^ To test these hypotheses , we measured mRNAs encoding the NMDAR 1 , GluR 1 , GluR 7 , and KA 1 subunits of glutamate receptor in the left superior frontal gyrus from 21 elderly schizophrenics with varying histories of antipsychotic drug treatment and nine normal drug free elderly controls . ^^^ There were significant negative correlations between NMDAR 1 , GluR 1 , GluR 7 , and KA 1 mRNA levels and time without neuroleptic medication before death in schizophrenics , indicating that levels of the glutamate receptor mRNAs decline rapidly after drug withdrawal . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Sections of the substantia nigra were obtained and receptor immunocytochemistry was performed using commercially available antibodies ( against subunits of ionotropic glutamate receptors : GluR 1 , GluR2 / 3 , GluR 4 , NMDAR 1 , NMDAR2A / B ; and subtypes of metabotropic glutamate receptors : mGluR1alpha , mGluR2 / 3 ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In the immunocytochemical study , immunoreactivity for glutamate or its ionotropic receptor subtypes , such as NR 1 , GluR 1 , GluR2 / 3 , GluR6 / 7 , and KA 2 , was examined in the median eminence of OVX rats under electron microscopy . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Our results demonstrate that DA regulates the phosphorylation state of the NR 1 subunit of NMDA type glutamate receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Turnover analysis of glutamate receptors identifies a rapidly degraded pool of the N methyl D aspartate receptor subunit , NR 1 , in cultured cerebellar granule cells . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Expression of glutamate receptor subunit / subtype messenger RNAS for NMDAR 1 , GLuR 1 , GLuR 2 and mGLuR 5 by accumbal projection neurons . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
An antisense oligodeoxynucleotide which specifically blocked the production of the glutamate receptor subtype NMDAR 1 was administered to the nucleus tractus solitarius ( NTS ) in order to examine the role of this receptor in baroreflex control of heart rate . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In the present study , we sought to localize glutamate receptor ( GluR ) subunits ( GluR 5 / 6 / 7 , GluR 2 / 3 and N methyl D aspartate receptor 1 [ NMDAR 1 ] ) and a glutamate transporter subtype [ GLT 1 ] within the leech CNS using mono and polyclonal antibodies . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In follow up studies , immunocytochemical and in situ hybridisation analysis of the NMDAR 1 and NMDAR 2 glutamate receptor subunits confirmed their widespread distribution in regions containing GnRH perikarya , but no colocalization within GnRH neurons was observed . ^^^ The resistance of GnRH neurons to the neurotoxic actions of two different glutamate agonists and the failure to detect colocalisation of NMDAR 1 or NMDAR 2 subunits within GnRH perikarya are consistent with the notion that the effects of glutamate upon GnRH secretion are not exerted directly upon GnRH cell bodies . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The effect of treatment with the D 1 dopamine receptor agonist SKF 38393 on the expression of metabotropic glutamate receptor 1 , 3 , 4 and 5 receptor subtypes and of the glutamate N methyl D aspartate ionotropic receptor subunits NRI , NR2A and NR2B was analysed using in situ hybridization . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To further examine the role of N methyl D aspartate ( NMDA ) and alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate ( AMPA ) glutamate receptors in these responses , double labeling studies of immunoreactivity for c Fos protein and either NMDA ( NR 1 ) or AMPA ( mGluR2 / 3 ) receptor expression were conducted in normoxic rats and in hypoxic rats receiving vehicle , MK 801 , or NBQX . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Since [ 3H ] L 689 , 560 , [ 3H ] CGP 39653 and [ 3H ] ifenprodil label the glycine , glutamate and ifenprodil sites of the NMDA receptor complex , which are associated with NR 1 , NR1 / NR2A and NR1 / NR2B subunits respectively , our findings suggest that NR2B containing receptors are selectively up regulated in superior temporal cortex in schizophrenia . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
By exchanging ion pore domains between functional glutamate receptors ( GluR 1 , GluR 6 and NMDAR 1 ) with known pore properties we first tested the feasibility of the domain swapping method . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The focus of the present study was on the role of Ca2+ entry into neurons , either through receptor or voltage gated channels , in the expression of the NMDA receptor subunit NR 1 and the 71 kDa glutamate binding protein ( GBP ) of a glutamate / NMDA receptor like complex . ^^^ Activation or inhibition of other glutamate ionotropic receptors had no effect on the expression of NR 1 and GBP . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The down regulation of the functional effects of glutamate was dependent on the duration of PDC exposure and was accompanied by a reduced NMDAR 1 subunit expression and decreased [ 3H ] MK 801 binding , indicative of a pronounced structural rearrangement of NMDA receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
No GnRH neurons were immunopositive for NR 1 , indicating that effects of glutamate on GnRH neurons are mediated by interneurons or other glutamate receptor subunits or types . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NMDA NR 1 subunit mRNA and glutamate NMDA sensitive binding are differentially affected in the striatum and pre frontal cortex of Parkinson ' s disease patients . ^^^ Changes in the levels of mRNA for the NR 1 subunit of the glutamate NMDA receptor and in NMDA sensitive glutamate binding were investigated in consecutive sections of the prefrontal cortex and striatum of control and Parkinson ' s disease ( PD ) post mortem brain using in situ hybridisation and receptor autoradiography . ^^^ In the striatum , levels of glutamate binding to the NMDA receptor detected by receptor autoradiodgraphy were significantly reduced in the PD group , while no change could be detected at a macroscopical level in NMDA NR 1 mRNA expression . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
This region of NR 1 is most similar to bacterial leucine / isoleucine / valine binding protein , a globular amino acid binding protein containing two lobes , similar to the downstream S 1 S2 region of glutamate receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
GluR 1 , GluR2 / 3 , and NMDAR 1 subunits of glutamate receptors were quantified from immunoblots in these brain nuclei in rats at 24 h and 3 weeks after discontinuing 1 week of daily cocaine injections . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The NMDA receptor channel is formed from two gene products from two glutamate receptor subunit families , termed NR 1 and NR 2 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To investigate the role of NMDA receptor subunits in the neuroendocrine functions of the magnocellular neuroendocrine cells of the hypothalamus , we examined the effects of osmotic stimulation on the protein expression of the NMDA receptor subunits , NR 1 and NR2B , important in binding glycine and glutamate , respectively . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Western blot analyses using antibodies against different subunits of 2 amino 3 hydroxy 5 methylisoxazole 4 propionic acid ( AMPA ) and N methyl D aspartate ( NMDA ) types of ionotropic glutamate receptors indicate that AMPA receptor subunits ( GluR 1 , GluR2 / 3 , and GluR 4 ) , but not NMDA receptor subunits ( NR 1 and NR2A ) , are proteolytically cleaved after exposure of hippocampal neurons to apoptotic insults , including Abeta , and that the caspase inhibitor zVAD fmk suppresses such cleavage . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We performed an electron microscopic study of S 1 cortex by using postembedding immunogold histochemistry to examine the subcellular distribution of alpha amino 3 hydroxy 5 methylisoxazole 4 propionate ( AMPA ) receptors ( assessed with an antibody recognizing the glutamate receptor 2 and 3 [ GluR 2 and GluR 3 ] subunits ) and to compare this distribution with that of N methyl D aspartate ( NMDA ) receptors ( assessed with an antibody for the NR 1 subunit ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We measured the glutamate induced increase of calcium concentration in fibroblasts expressing one of the NR 1 splice forms and the NR2B subunit . ^^^ The increase of calcium concentration after glutamate application had a positive correlation with the amount of NR 1 splice forms expressed on the cell surface . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In this study we have used double label immunocytochemistry to analyze the expression of the glutamate receptor subunits GluR 1 , GluR2 / 3 , NR 1 , mGluR 1 , and mGluR 5 in the dopaminergic cells of the striatum . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In vitro studies show that while NR 2 alone is nonfunctional , NR 1 alone produces weak currents to glutamate or NMDA . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Localization of alternatively spliced NMDAR 1 glutamate receptor isoforms in rat striatal neurons . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The present study examined the electrophysiological effects produced by activation of specific dopamine ( DA ) receptors and the distribution of DA receptor subtypes and glutamate receptor subunits [ N methyl D aspartate ( NMDAR 1 ) and GluR 1 ] in cortical tissue samples obtained from children ( ages 3 months to 16 years ) undergoing epilepsy surgery . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We have quantitated the protein levels of alpha amino isoxazolepropionic acid ( AMPA ) type ( GluR 1 ) and N methyl D aspartate type ( NMDAR 1 ) glutamate receptors in postmortem brain tissues of patients with Alzheimer ' s disease and age matched controls using western blotting . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The trophic action of chronic NMDA treatment appears to involve a downregulation of glutamate receptors as shown by both a reduction in the obligatory NR 1 subunit protein of the NMDA receptor and a decrease in the kainate induced Co ( 2+ ) uptake in MNs . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We conclude that alternative splicing of NR 1 pre mRNA transcripts may be regulated by developmental cues that modulate the degree of glutamate receptor activation . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
This is a study of the effect of the unilateral administration of dopamine ( DA ) in the pars compacta of the substantia nigra ( SN ) of the rat on striatal glutamate receptor subunit ( GluR 1 , GluR 2 and NMDAR 1 ) gene expression determined by in situ hybridization . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Distribution of glutamate receptor subunit NMDAR 1 in the hippocampus of normal elderly and patients with Alzheimer ' s disease . ^^^ Notably , the overall pattern of NMDAR 1 immunoreactivity is distinct from that observed with antibodies against AMPA receptor subunits and suggests a differential role of various inotropic glutamate receptors in hippocampal plasticity in AD . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The immunohistochemical localization of N methyl D aspartate ( NMDA ) glutamate receptor subunit , NR 1 was investigated in the chinchilla cristae ampullaris and utricular maculae at the light and electron microscopy level with the use of specific antipeptide antibodies . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Similarly , mRNAs encoding all four alpha amino 3 hydroxy 5 methylisoxazole 4 propionate ( AMPA ) type glutamate receptor subunits and the NR 1 and NR2A , 2B , and 2D subunits of the NMDA type glutamate receptors were detected , suggesting that various combinations of these subunits mediate the cellular response to synaptically released glutamate . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To define further sites for functional interactions between opiate ligands and excitatory amino acid receptors , the ultrastructural localization of the mu opioid receptor ( MOR ) was examined with respect to either the kainate receptor ( KAR ) or the R 1 subunit of the N methyl D aspartate ( NR 1 ) type glutamate receptor in the LC . ^^^ Gold silver labeling for MOR and peroxidase labeling for either KAR or NR 1 indicated that the MOR often was localized to the plasma membrane of dendrites that also exhibited immunolabeling for either glutamate receptor subtype . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To characterize molecular events that precede cell death following transient focal ischemia , in situ hybridization histochemistry was used to measure levels of glutamate receptor subunit 1 ( GluR 1 ) , GluR 2 , GluR 3 , N methyl D aspartate receptor subunit 1 ( NR 1 ) and preproenkephalin messenger RNAs in adult rats at various recirculation times ( 1 . 5 , 3 and 24 h ) following a 90 min period of middle cerebral artery occlusion . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Double immunostaining revealed that many of the constitutively expressed Zif 268 positive neurons were GABAergic but very few were cholinergic or neuronal nitric oxide synthase ( nNOS ) positive , and some of the Zif 268 positive neurons were also immunopositive for a glutamate NMDA receptor subunit NR 1 or NR2A . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The expression of the glutamate receptors has been determined at multiple levels of gene expression in postmortem brain samples from schizophrenics and controls ; while results have not been entirely consistent from study to study , several generalizations have emerged from this literature : ( 1 ) The AMPA receptor is abnormally decreased in expression in the schizophrenic hippocampus , involving decreased levels of subunit transcripts and protein levels , as well as binding sites , ( 2 ) similar changes are seen for kainate receptor expression in the hippocampus , and ( 3 ) the obligate NMDA receptor subunit , NMDAR 1 , may be abnormally expressed in some cortical regions in schizophrenia . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Alternative splicing of the NMDAR 1 glutamate receptor subunit in human temporal lobe epilepsy . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The receptor protein expression of glutamate receptors mGluR 1 , GluR 2 , GluR5 / 7 and NMDAR 1 were not modified in response to PCP treatment . 6 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The study was designed to analyze the levels of mRNA coding for NMDAR 1 , the essential subunit of the N methyl D aspartate ( NMDA ) receptor subtype , and for GluR 1 , an AMPA glutamate receptor subunit , after repeated immobilization stress in rat hippocampus . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In the present study , we hypothesized that the expressions of glutamate receptor , NMDA receptors ( NMDAR 1 ) and neuronal nitric oxide synthase ( nNOS ) were colocalized and were also correlated with that of cytochrome oxidase ( CO ) in a subset of neurons . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Immunocytochemical studies demonstrated the presence of the glutamate receptor proteins NMDAR 1 , NMDAR2A / B , GluR 1 , GluR 2 , GluR2 / 3 , GluR 4 , GluR6 / 7 , and KA 2 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glycine concentration response curves from acutely dissociated hippocampal neurons revealed a 5 and 86 fold reduction in receptor glycine affinity in mice carrying Grin 1 ( D481N ) and Grin 1 ( K483Q ) mutations , respectively , whereas receptor glutamate affinity remained unaffected . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
This study was aimed to investigate some of the underlying mechanisms of the preconvulsive behavior elicited by unilateral SNpr DA injection by the study of changes in the gene expression of glutamate receptor subunits ( GluR 1 , GluR 2 and NMDAR 1 ) and of changes in animal behavior following coinfusion of DA and a DA D 1 antagonist SCH 23390 into the SNpr . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
CONCLUSIONS : The loss of EAAT 1 in glaucoma may account for the elevated level of glutamate found in glaucomatous vitreous and lead to a compensatory downregulation of NMDAR 1 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In order to investigate the process of gene expression of N methyl D aspartate glutamate receptor ( NMDAR ) subunits in the rat neostriatum and how this relates to motor behaviors , a single dose of antisense phosphodiester oligodeoxynucleotide specific for NMDAR 1 was unilaterally applied in the neostriatum in a stereotaxic apparatus . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Alpha actinin ( alpha actinin 2 ) is a protein which links the NR 1 and NR2B subunits of N methyl D aspartate ( NMDA ) glutamate receptors to the actin cytoskeleton . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Expressions of AMPA ( GluR 2 , GluR 3 , and GluR 4 ) and NMDA ( NR 1 and NR 2 ) glutamate receptors in the spiral ganglion cells of the cochlea were analyzed both at protein and mRNA levels in control and deaf rats between week 0 ( P 14 ) and week 8 ( P 70 ) after deafness induced by a daily injection of kanamycin at P 0 P14 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
This article reviews the diversity that has been found in the subunit composition of GABA , glycine , alpha amino 3 hydroxy 5 methyl 4 isoxazole propionic acid and N Methyl , D aspartate ( NMDA ) receptors in the mammalian auditory brain stem and provides new data on how the NMDAR 1 glutamate receptor subunit changes as a consequence of deafness . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We also demonstrate that synaptic AMPA and NMDA receptor clusters form with a similar time course during synaptogenesis and that functional AMPA receptors cluster independently of activity and glutamate receptor activation , including following the deletion of the NMDA receptor NR 1 subunit . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In this study , mRNA for CRH and selected ionotropic glutamate receptor ( iGluR ) subunits ( NR 1 , GluR 2 , GluR 3 ) was quantified in the hippocampus of pigs in which stress was simulated by central administration of CRH ( 100 microg ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Fluctuation analysis of the glutamate evoked current revealed that the NMDAR 1 W 5L mutation increased channel mean open time , providing further evidence for an alteration in gating . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We visualized here the distribution of the major ionotropic glutamate receptors in quail by immunocytochemical methods by using commercial primary antibodies raised against rat glutamate receptor 1 and receptors 2 3 ( GluR 1 , GluR2 / 3 : AMPA subtype , Chemicon , CA ) , rat glutamate receptors 5 7 ( GluR 5 7 : kainate subtype , Pharmingen , CA ) , and rat NMDA receptors ( NMDAR 1 , Pharmingen , CA ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NMDA receptors represent a subtype of the ionotropic glutamate receptor family , comprising three classes of subunits ( NR 1 , NR2A D , NR 3 ) , which exhibit distinct patterns of regional and developmental expression in the CNS . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We are interested in studying the co localization of NMDA glutamate receptor subunits ( NR 1 , NR2A / B ) and AMPA glutamate receptor subunits ( GluR 1 , GluR 2 , GluR2 / 3 and GluR 4 ) in individual neurons of the rat vestibular nuclei . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Dysfunction of N methyl D aspartate ( NMDA ) type ionotropic glutamate receptors has been implicated in the etiology of schizophrenia based on psychotomimetic properties of the antagonist phencyclidine ( PCP ) and observation that mice expressing low levels of the N methyl D aspartate receptor NR 1 subunit exhibit behavioral alterations that may be ameliorated by neuroleptic drugs . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Otherwise , the observed diminution of NMDAR 1 1 splice variant mRNA and protein levels may , at least partially , explain the decreased vulnerability of nNOS alpha ( Delta / Delta ) mice to glutamate mediated neurotoxicity . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NMDA receptors , an ionotropic subtype of glutamate receptors ( GluRs ) forming high Ca ( 2+ ) permeable cation channels , are composed by assembly of the GluRzeta subunit ( NR 1 ) with any one of four GluRepsilon subunits ( GluRepsilon 1 4 ; NR2A D ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The NR 1 gene encodes the major subunit that is responsible for channel function , and NR 1 / mice die at birth , inhibiting the study of glutamate signaling in postnatal neurons . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We have stably transfected HEK 293 cells with recombinant human CaBP in order to determine the influence of this protein upon transient increases in intracellular ionic calcium concentration ( [ Ca ( 2+ ) ] ( 1 ) ) induced either by transient transfection of the NR 1 and NR2A subunits of the N methyl D aspartate ( NMDA ) receptor and brief exposure to glutamate , photolysis of the caged calcium compound NP EGTA , or exposure to the Ca ( 2+ ) ] ionophore 4 Br A 23187 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Moreover , there is a significant positive correlation between the levels of conditioning and greater immunoreactivity with the glutamate receptor 4 ( GluR 4 ) AMPA receptor subunit in the abducens motor nuclei , but not with NMDAR 1 or GluR 1 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Sleep recordings , Morris water maze experiments , and immunohistochemistry for NMDA NR 1 glutamate receptor , c fos protein , and apoptosis [ nuclear immunoreactivity for single stranded DNA and terminal deoxynucleotidyl transferase mediated biotinylated UTP nick end labeling assay ] were conducted in EHYP exposed Sprague Dawley male rats . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Unilateral hypoglossal nerve axotomy was used as a model to analyse immunohistochemically the expression of the GluR 1 , GluR 2 , GluR 3 , and GluR 4 glutamate receptor subunits of the alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate ( AMPA ) subtype and the NR 1 subunit of the N methyl D aspartate ( NMDA ) subtype in the different morphofunctional hypoglossal pools from 1 to 45 days postaxotomy . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Fos immunostaining was used as a marker of neuronal activity following intracranial self stimulation ( ICSS ) of the medial forebrain bundle ( MFB ) in the rat , and was combined with immunostaining for tyrosine hydroxylase ( TH ) , serotonin ( 5 HT ) , gamma aminobutyric acid ( GABA ) , or NR 1 ( one of the glutamate N methyl D aspartate receptor subunits ) for purposes of neurochemical identification . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To gain a better understanding about the precise sites of action of glutamate and the subunit compositions of the receptors involved in the glutamatergic neurotransmission in the hypothalamus and septum , in situ hybridization was used with 35S labeled cRNA probes for the different ionotropic receptor subunits , including glutamate receptor subunits 1 4 ( GluR 1 GluR4 ) , kainate 2 , GluR 5 GluR7 , N methyl D aspartate ( NMDA ) receptor 1 ( NMDAR 1 ) , and NMDAR2A NMDAR2D . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Furthermore , UBCs identified by calretinin immunoreactivity expressed the glutamate receptor subunits GluR2 / 3 , NMDAR 1 , and mGluR2 / 3 , like they do in the mature mouse cerebellum in situ . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glutamate NMDAR 1 receptors localised to nerves in human Achilles tendons . ^^^ In this investigation , we show the presence of both free glutamate ( microdialysis ) and glutamate NMDAR 1 receptors ( immunohistochemical analyses of tendon biopsies ) , in tendons from patients with chronic Achilles tendon pain ( Achilles tendinosis ) and in controls ( pain free tendons ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The distribution of glutamate receptors in the monkey subthalamic nucleus was studied using affinity purified polyclonal antibodies to GluR 1 , phosphorylated GluR 1 , GluR2 / 3 , NMDAR 1 , mGluR1a and mGluR 5 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Nitric oxide synthase positive neurons in the rat superior colliculus : colocalization of NOS with NMDAR 1 glutamate receptor , GABA , and parvalbumin . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In cells exposed to the glutamate transport blocker , L trans pyrrolidine 2 , 4 dicarboxylate ( PDC ) , the expression of the C 1 exon positive NR 1 mRNA variant was reduced by about 40 % whereas , the expression of C 1 negative mRNA was increased leading to significant reduction of the +C1 / C 1 ratio . ^^^ The expression of the N 1 negative NR 1 variants was slightly reduced following exposure to PDC , indicating that increased medium levels of glutamate changed the relative abundance of NR 1 splice variant expression but did not reduce the overall NR 1 transcription . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Under control conditions , receptors containing mutated NR 1 and NR 2 subunits show much smaller glutamate responses than wild type receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
E2F1 ( + / + ) and ( / ) cultures were comparable , in that they contained similar neuronal densities , responded with similar increases in intracellular calcium concentration ( [ Ca ( 2+ ) ] 1 ) to glutamate receptor agonists , and showed similar NMDA receptor subunit mRNA expression levels for NR 1 , NR2A and NR2B . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In normal control animals , regional differences in the expression of several glutamate receptor subunit / subtypes , e . g . , NR 1 and NR2A subunits of the N methyl D aspartic acid ( NMDA ) receptor , GluR 2 and KA 2 subtypes of non NMDA receptors , and mGluR 1 and mGluR 7 metabotropic glutamate receptors , were consistent with previous results from studies using in situ hybridization histochemistry , suggesting that the real time quantitative PCR method was a reliable procedure for evaluation of changes in mRNA expression . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
N methyl D aspartate receptors ( NRs ) are a group of ionotropic glutamate receptors in the brain and they are composed of heteromeric subunits ( NR 1 , NR2A D and NR 3 ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In vivo microdialysis and immunohistochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMDAR 1 receptors , but no signs of inflammation , in Jumper ' s knee . ^^^ In the biopsies , there were no inflammatory cell infiltrates , but , for the first time , it was shown that there was immunoreaction for the glutamate receptor NMDAR 1 in association with nerve structures in human patellar tendons . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NR 1 ( F639A ) did not alter the agonist potency of glutamate but did produce a leftward shift in the glycine concentration response for receptors containing NR2A and NR2B subunits . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The authors used in situ hybridization to determine NMDAR 1 , NMDAR2A NMDAR2D , gluR 1 gluR7 , KA 1 , and KA 2 subunit mRNA levels and receptor autoradiography to determine binding to glutamate binding sites of the three receptor subtypes and to the glycine , polyamine , and ion channel binding sites of the NMDA receptor . ^^^ RESULTS : Glutamate receptor expression was lower at both transcriptional ( NMDAR 1 , NMDAR2B , NMDAR2C , gluR 1 , gluR 3 , and KA 2 subunit mRNAs ) and posttranscriptional ( [ ( 3 ) H ] ifenprodil and [ ( 3 ) H ] MDL 105 , 519 binding to polyamine and glycine sites of the NMDA receptor ) levels in the thalamus in patients with schizophrenia than in comparison subjects , but differences were most prominent in nuclei with reciprocal projections to limbic regions . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Asymmetrical reductions of hippocampal NMDAR 1 glutamate receptor mRNA in the psychoses . ^^^ Using in situ hybridisation histochemistry ( ISHH ) , we measured mRNA for the obligatory NMDAR 1 subunit of the NMDA glutamate receptor in post mortem samples of hippocampus from schizophrenics , depressives , bipolar patients and normal controls . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Thus , glutamate receptor function can be altered in the mouse by regulated NR 1 ( R ) transgene expression . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To determine the role of the intracellular C terminal tails of glutamate receptor subunits in the synaptic targeting of AMPARs and NMDARs , we fused the tails of the AMPAR subunits , GluR 1 and GluR 2 , and the NMDAR subunit , NR 1 , to the human T lymphocyte membrane protein CD 8 and expressed these constructs in HEK 293 cells and cultured hippocampal neurons . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Here , the effect of Con G on recombinant NMDA receptors carrying point mutations within the glycine and glutamate binding pockets of the NR 1 and NR2B subunits was studied using whole cell voltage clamp recording from cRNA injected Xenopus oocytes . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Furthermore , glutamate receptor subunit profiles ( GluR 1 , GluR2 / 3 , GluR2 / 4 , GluR5 / 6 / 7 and NMDAR 1 ) were also determined for these cells . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
When coexpressed with NR 1 and NR2A in heterologous cells , NR3B suppressed glutamate induced current similarly to NR3A . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
This study was undertaken to characterize the AMPA ( GluR 1 , GluR2 / 3 , and GluR 4 ) , KA ( GluR5 / 6 / 7 ) , and NMDA ( NR 1 ) ionotropic glutamate receptor subunits and to determine their distribution during the development of the chick retina by Western blotting and immunohistochemistry . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We have localized regions in the S 1 binding domain of both subunits required for the transmission of allosteric signals from the glutamate binding NR2A subunit to the glycine binding NR 1 subunit . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The mRNA of the NR 1 subtype of glutamate receptor in Alzheimer ' s disease . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
These currents have been generally ascribed to a functional association between NR 1 and the endogenous glutamate receptor subunit XenU 1 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
These effects of InsP 6 appear to be specific to AMPA receptors , as neither 3H glutamate binding to NMDA receptors nor levels of NR 1 and NR2A subunits in P 2 and P 3 fractions were affected . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Conventional heteromeric NMDARs composed of NR 1 and NR2A D subunits require dual agonists , glutamate and glycine , for activation . ^^^ Remarkably , when co expressed in Xenopus oocytes , NR3A or NR3B co assembles with NR 1 to form excitatory glycine receptors that are unaffected by glutamate or NMDA , and inhibited by D serine , a co activator of conventional NMDARs . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Moreover , we detected an enrichment of glutamate receptors subunits that including NR 1 subunit of NMDA receptors and GluR 1 subunit of AMPA receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Age related changes in GluR 2 and NMDAR 1 glutamate receptor subunit protein immunoreactivity in corticocortically projecting neurons in macaque and patas monkeys . ^^^ We performed an immunohistochemical analysis of neurons forming short and long corticocortical projections in young and old monkeys using antibodies to the GluR 2 and NMDAR 1 glutamate receptor subunit proteins . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Here we describe the use of real time quantitative PCR using a fluorescent TaqMan probe , to study the regional differences in expression of glutamate receptor subunit / subtype genes ( NR 1 , NR2A , GluR 2 , KA 2 , mGluR 1 , mGluR 7 ) in the central vestibular system including the vestibular nucleus complex , inferior olive and cerebellar flocculus . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
RESULTS : Single dose of morphine was followed by a decrease in gene expression of glutamate receptor subunit NMDAR 1 in the adrenal gland . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To further define the amino acids through which glutamate activates the receptor , we generated single site mutations to the NR2A subunit , and expressed them with wild type NR 1 in HEK 293 cells . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To elucidate the morphological changes in immunopositive cells of ionotropic glutamate receptors within intrastriatal ' developing ' grafts of fetal ventral mesencephalon ( VM ) in 6 hydroxydopamine lesioned rats , immunohistochemistry was performed to detect cells expressing N methyl D aspartate ( NMDA ) receptor subunit 1 ( NR 1 ) , the alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate ( AMPA ) receptor subunits ( GluR 1 , GluR2 / 3 , and GluR 4 ) , or tyrosine hydroxylase ( TH ) in the intrastriatal VM grafts at 1 , 4 , and 12 weeks following transplantation . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The immunohistochemical localization of the NMDA glutamate receptor subunits NR 1 , NR2A , and NR2B was investigated in the rat vestibular periphery at the light and electron microscopy level using specific antipeptide antibodies . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NMDA receptors are ionotropic glutamate receptors assembled of subunits of the NR 1 and of the NR 2 family ( NR2A NR2D ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In this study , the protein expression levels of several ionotropic glutamate receptor subunits ( N methyl D aspartate ( NMDA ) subunits NR 1 , NR2A , NR2B , and alpha amino 3 hydroxy 5 methyl 4 isoxazoleproprionic acid ( AMPA ) receptor subunits GluR 1 , GluR 2 , GluR 4 ) were quantified in particulate preparations from rat spinal cord at various ages after birth . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Expression of the N methyl d aspartate receptor 1 ( NR 1 ) subunit of glutamate receptors correlated with the activity of the Sp 1 related factor , specifically through an Sp 1 element in the NR 1 promoter . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Expression of mRNA for glutamate receptor subunits was either unaffected ( NR 1 ) or decreased ( GluR 2 and GluR 3 ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The constitutive subunit of the NMDA ionotropic glutamate receptor , NMDAR 1 , was expressed in all neurons of the grey matter and was not modified in the spinal cord of mnd mice in either its normal or phosphorylated form . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We investigated the distribution of the glutamate receptor subunits , alpha amino 3 hydroxy 5 methyl 4 isoazolepropionic acid ( AMPA ) GluR 2 and GluR2 / R3 , and N methyl D aspartate ( NMDA ) NR 1 , and the timing of their appearance during early development of the mouse vestibular and spiral ganglia . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Systematic mutation analysis of the human glutamate receptor , ionotropic , N methyl D aspartate 1 gene ( GRIN 1 ) in schizophrenic patients . ^^^ Mohn recently reported that transgenic mice with the reduced glutamate receptor , ionotropic , methyl D aspartate 1 gene ( GRIN 1 ) ( formerly referred to as NMDAR 1 ) expression display schizophrenia like behaviors , which can be ameliorated by antipsychotic drug treatment . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To determine if this effect was dependent on modulation of glutamate receptor gene expression , we studied the effect of gonadal hormones on levels of the NR 1 subunit of NMDA receptor and the GluR 2 subunit of the AMPA subtype of glutamate receptor in the rat striatum , using autoradiographic immunocytochemistry . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Pentamidine inhibited a constitutively active NR 1 ( T648A ) / NR2B NMDA receptor in a manner similar to its inhibition of a glutamate gated wild type NMDA receptor , but different from its inhibition of constitutively active delta 2 ( A654T ) receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We have previously shown that primary human megakaryocytes express the N methyl d aspartate acid ( NMDA ) receptor 1 ( NR 1 ) subunit of NMDA type glutamate receptors , which appear to be pharmacologically similar to those identified at neuronal synapses , responsible for mediating excitatory neurotransmission in the central nervous system . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
One of the alpha amino 3 hydroxy 5 methyl 4 isoxazole propionic acid ( AMPA ) receptors , Glutamate receptor 2 ( GluR 2 ) was also investigated to compare with NR 1 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Using semi quantitative Western blot techniques and immunohistochemistry with the use of antibodies that recognize subunits of the KA ( GluR 5 , 6 , 7 ) , AMPA ( GluR 1 , GluR 2 , and GluR 4 ) , and NMDA ( NMDAR 1 and NMDAR2A / 2B ) receptors , we found no significant strain dependent differences in the expression or distribution of these glutamate receptor subunits in the intact hippocampus . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system , and the N methyl D aspartate selective glutamate receptor ( NR ) consisting of the NR 1 subunit and an NR 2 or NR 3 subunit plays crucial roles in synaptic transmission , plasticity , and learning and memory . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Further studies concentrated on the presence and the distribution of glutamate receptors : NMDAR 1 , GluR 1 , GluR 2 / 3 , GluR 5 / 6 / 7 , mGluR 2 / 3 , and mGluR 5 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Based on homology modeling to the crystal structure of the glutamate binding site of the 2 amino 3 ( 3 hydroxy 5 methyl 4 isoxazolyl ) propionic acid receptor GluR 2 , cysteines were introduced into the NR 1 subunit as chemical sensors for three thiol reactive derivatives of the competitive antagonist L 701324 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Distribution of NADPH diaphorase and expression of nNOS , N methyl D aspartate receptor ( NMDAR 1 ) and non NMDA glutamate receptor ( GlutR 2 ) genes in the neurons of the hippocampus after domoic acid induced lesions in adult rats . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Functional N methyl d aspartate ( NMDA ) glutamate receptors are composed of heteromeric complexes of NR 1 , the obligatory subunit for channel activity , and NR 2 or NR 3 family members , which confer variability in the properties of the receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Organotypic hippocampal slice cultures , derived from 1 week old rats , were treated with 100 ng / ml GDNF for either 2 or 5 days , followed by Western blot analysis of NMDAr subunit 1 ( NR 1 ) and two glutamate transporter subtypes , GLAST and GLT 1 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Tat or NMDA treatment of mixed cultures for 24 h resulted in increased extracellular glutamate ( [ Glu ] e ) and NMDA receptor 1 ( NMDAR 1 ) expression , potential contributors to apoptosis . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The glycine binding site of this subtype of ionotropic glutamate receptors is formed by the S 1 and S 2 regions of the NR 1 subunit . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Tissues from the accumbens and ventral tegmental area ( VTA ) were assayed for candidate molecular neuroadaptations , including enzyme activities of cAMP dependent protein kinase ( PKA ) and adenylate cyclase ( AC ) , and protein expression of cyclin dependent kinase 5 ( cdk 5 ) , tyrosine hydroxylase ( TH ) and glutamate receptor subunits ( GluR 1 , GluR 2 and NMDAR 1 ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NMDA receptors require both glycine and glutamate for activation with NR 1 and NR 2 forming glycine and glutamate sites , respectively . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Although the lateral dendrites of mitral and tufted cells have been reported to respond to glutamate , they did not display significant plasma membrane labeling for the NR 1 subunit or for PSD 95 , suggesting that the physiological effects of glutamate at these sites are mediated by NMDA autoreceptors that are not clustered and occur only at a low density on the dendritic surface . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The NMDA receptors are composed of a common glutamate receptor , an ionotropic NMDA 1 ( GRIN 1 ) subunit and one of four GRIN 2 subunits ( GRIN2A GRIN2D ) , combined in an undetermined ratio to make up the receptor complex . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Four days later , rats were perfused and brain stem sections containing the SSN were processed for fluorescent immunohistochemistry for N methyl D aspartate receptor subunit 1 ( NMDAR 1 ) and vesicular glutamate transporters ( VGLUT 1 and VGLUT 2 ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In order to explore the effects of clozapine on the NMDA class of glutamate receptors , oocytes expressing the NMDA receptor NR 1 subunit , coupled with different NR 2 subunits , were exposed to clozapine and NMDA induced current was measured with two electrode voltage clamp techniques . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The N methyl D aspartate glutamate receptor ( NMDAR ) is assembled as a tetramer containing NR 1 and NR 2 , and possibly NR 3 subunits , NR 1 being essential for the formation of the ion channel . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To understand the genetic mechanism controlling the expression of the NMDA subtype of glutamate receptors during neuronal differentiation , we studied activation of the N methyl D aspartate receptor subunit 1 ( NR 1 ) gene and the role of the repressor element 1 ( RE 1 ) element in NR 1 promoter activation . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Gene expression of glutamate receptors GluR 1 and NR 1 is differentially modulated in striatal neurons in rats after 6 hydroxydopamine lesion . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We show evidence by confocal microscopy for the presence of the NR 1 subunit of the NMDA glutamate receptor subtype , proposed to be a key regulatory element , at these large endings . ^^^ Furthermore , we also show evidence by FRIL double immunogold labeling that the NR 1 subunit of the NMDA glutamate receptor is present at postsynaptic densities closely associated with gap junction plaques containing Cx 35 at mixed synapses across the goldfish hindbrain . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glycine acts as a necessary coagonist for glutamate at the NMDA receptor ( NMDAR ) complex by binding to the strychnine insensitive glycine B binding site on the NR 1 subunit . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
However , co expression with other related ionotropic glutamate receptor subunits ( GluR 1 and NR 1 ) does not facilitate the cell surface expression of KA 2 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Gene expression of NR 1 receptor subunit of N methyl D aspartate ( NMDA ) glutamate receptor in the ventral tegmental area ( VTA ) was found to be lower in anhedonic rats . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The NMDA receptor subunit 1 ( NR 1 ) gene is indispensable for receptor function , and knock out mice die at birth , inhibiting the study of glutamate signalling in postnatal neurons . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Through a negative feedback loop , CaM inhibits Ca2+ influx through N methyl D aspartate type glutamate receptors in neurons by binding to the C 0 region in the cytosolic tail of the NR 1 subunit . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In addition , dorsocaudal brain stem tissue lysates were harvested at 1 h , 6 h , 1 day , 3 days , 7 days , 14 days , and 30 days of SH and IH and analyzed for NR 1 , NR2A , and NR2B NMDA glutamate receptor expression by immunoblotting . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
PAT 2 is expressed in neurons positive for the N methyl d aspartate subtype glutamate receptor subunit NR 1 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In comparison with age matched control rats , a correlated decreasing expression of nitric oxide synthase ( NOS ) , glutamate and NMDAR 1 was observed in the Purkinje cells of lobules 6 8 6 h after the treatment . ^^^ Moreover , at 24 h after cisPt , the expression of glutamate , NMDAR 1 and nicotinamide adenine dinucleotide phosphate diaphorase ( NADPHd ) reactivity was further decreased . ^^^ Findings show the importance of NO glutamate interactions via NMDAR 1 in the crucial phases of Purkinje cells differentiation and their involvement on Purkinje neurons dendrite branching as demonstrated by the patterns of the other glutamate receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We studied the influence of acute and repeated morphine ( 20 mg / kg i . p . or increasing dose for 10 days ) and cocaine ( 3x20 mg / kg i . p . per day at hourly intervals , for 1 or 5 days ) administration on the expression of glutamate NMDA receptor subunit 1 ( NMDAR 1 ) in the central and basolateral nuclei of the rat amygdala and hippocampal formation . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
This pathway is distinguished by specific affinities of its neurons to antisera raised against glutamate , aspartate , gamma aminobutyric acid ( GABA ) , choline acetyltransferase ( ChAT ) , and a N methyl D aspartate type 1 receptor protein ( NMDAR 1 ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In addition , reverse transcription polymerase chain reaction technique and sequencing analysis revealed that glutamate transporters ( GLT 1 and EAAC 1 ) and ionotropic glutamate receptors ( NR 1 , NR2B , GluR 6 , and KA 2 ) existed in mouse sperm as well as in human sperm . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Accordingly , we also found evidence by confocal and FRIL double immunogold labeling that the NR 1 subunit of the NMDA glutamate receptor , proposed to be a key regulatory element , is present at postsynaptic densities closely associated with gap junction plaques containing Cx 35 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Abnormal molecules included measures of synaptic density or neuronal plasticity ( reelin , SNAP 25 , BDNF , Complexin 1 and 2 ) , as well as parvalbumin , tyrosine receptor kinase A , glucocorticoid receptors , glutamate NR 1 receptor subunits , serotonin 5HT2 ( A ) and 5HT1 ( B ) receptors , and dopamine D ( 5 ) receptors . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
N methyl D aspartate ( NMDA ) receptors , a subtype of glutamate receptors ( GluRs ) formed by assembly of the GluRzeta subunit ( called NR 1 in rats ) with any one of four GluRepsilon subunits ( GluRepsilon 1 4 ; NR2A D ) , play an important role in excitatory neurotransmission , synaptic plasticity and brain development . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Double immunofluorescence was performed to visualize neurons showing coexpression of DARPP 32 with NMDA or AMPA receptor subunits ( i . e . , NR 1 , NR2a / b , glutamate receptor subunit 1 [ GluR 1 ] , GluR2 / 3 , and GluR 4 ) in the forebrains of rats . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Molecular models of the ligand binding domain of N methyl d aspartate subunit R 1 ( NR 1 ) were made using the published crystal structures of rat glutamate receptor B ( GluRB ) , the bacterial glutamate receptor ( GluR 0 ) , and the glutamine binding protein ( QBP ) of Escherichia coli . ^^^ NR 1 prefers smaller ligands ( glycine , serine , and alanine ) in comparison with GluRB and GluR 0 that bind l glutamate : the bulky side chain of W 731 in NR 1 dramatically reduces the size of the ligand binding site , functioning to selectively restrict recognition to glycine and the d isomers of serine and alanine . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Using standard immunohistochemical procedures , we investigated the changes in the expression of ionotropic glutamate receptor ( GluR ) subunits , GluRl , GluR5 / 6 / 7 , and NMDAR 1 , in the subthalamic nucleus of developing rats . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Our results show that : ( 1 ) retinotopic maps reorganize with time after an ischemic lesion ; ( 2 ) MAP 2 levels increase gradually from 1wPL to 5wPL ; ( 3 ) MAP 2 upregulation is associated with an increase in dendritic like structures surrounding the lesion and a decrease in GFAP positive cells ; ( 4 ) GAP 43 levels reach the highest point at 2wPL ; ( 5 ) NMDAR 1 and glutamate contents increase in parallel from 1wPL to 5wPL ; ( 6 ) GABA ( A ) alpha 1 levels increase from 1wPL to 2wPL but do not change after this time point ; and ( 7 ) GABA contents remain low from 1wPL to 5wPL . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In addition , RT PCR results revealed that glutamate transporters ( GLT 1 and EAAC 1 ) and ionotropic glutamate receptors ( NR 1 , NR2B , GluR 6 and KA 2 ) were expressed in mouse testis . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Moreover , activation of metabotropic glutamate receptors leads to the recruitment of the NMDA receptor subunit NR 1 to remodeled ER export sites . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Chronic PCP treated animals showed significant alterations in glutamate receptor subunits , particularly for the NR 1 , NR2B , NR2C , and NR2D components of the NMDA receptor . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Studies of p 38 mitogen activated protein kinase ( MAPK ) activation , morphologic changes including cell number , and the expression of the NR 1 and GluR 2 subunits , by reverse transcriptase PCR were evaluated at early postnatal ages ( postnatal day [ PD ] 8 14 ) in cerebral cortex of rats treated with monosodium glutamate ( MSG ; 4 mg / g body weight ) administered subcutaneously on PD 1 , 3 , 5 , and 7 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In goldfish brain , confocal microscopy revealed immunofluorescence for connexin 35 ( Cx 35 ) and NMDA R 1 ( NR 1 ) glutamate receptor protein in Mauthner Cell / Club Ending synapses . ^^^ By FRIL double labeling , NR 1 glutamate receptors were found in clusters of intramembrane particles in the postsynaptic membrane extraplasmic leaflets , and these distinctive postsynaptic densities were in close proximity ( 0 . 1 0 . 3 microm ) to neuronal gap junctions labeled for Cx 35 , which is the fish ortholog of connexin 36 ( Cx 36 ) found at neuronal gap junctions in mammals . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The possible implications of molecular mechanism underlying the neurotoxicity in association with necrosis , apoptosis , nitric oxide synthases ( nNos and iNOS ) and glutamate receptors ( NMDAR 1 and GluR 2 ) related genes and their expression in DA induced neuronal damage in the hippocampus have been discussed . . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Using a second approach in vitro , we confirmed that both exogenous glutamate and BDNF ( but not other neurotrophins ) were able to induce NR 1 phosphorylation , in particular at residue Ser 897 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glutamatergic sites were localized with vesicular glutamate transporter type 1 ( VGLUT 1 ) as presynaptic marker and the NR 1 subunit of the NMDA receptor and the GluR 1 subunit of the AMPA receptor as receptor markers . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The increased levels of extracellular glutamate , NMDA receptor zeta subunit ( NR 1 ) mRNA , NMDA receptor epsilon 1 subunit ( NR2A ) protein , phosphorylated Ca ( 2+ ) / calmodulin kinase 2 ( p CaMKII ) protein , c fos mRNA , c Fos protein , are observed in the specific brain areas of mice and / or rats showing signs of naloxone precipitated withdrawal . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
RT PCR demonstrated that ionotropic ( iGluR NR 1 ) and metabotropic ( mGluR Group 3 ) glutamate receptors are expressed in rodent lymphocytes . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Under standard conditions , cultured ventral spinal neurons cluster AMPA but not NMDA type glutamate receptors at excitatory synapses on their dendritic shafts in spite of abundant expression of the ubiquitous NMDA receptor subunit NR 1 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glycine coactivates glutamate N methyl D aspartate ( NMDA ) receptors by binding to a distinct recognition site on the NR 1 subunit . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In the present study , we employ the glutamate NMDA ( N methyl D aspartate ) R 1 receptor ( GRIN 1 ) transcript as a model system to identify the molecular determinants for a brain region specific exon silencing mechanism . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The present study examined the expression of glutamate , N methyl D aspartate receptor subunit 1 ( NMDAR 1 ) , GABA , GABAB receptors , glycine receptors , and glutamate receptor subunit 2 ( GluR 2 ) in the ventrolateral subnucleus of the solitary tract nucleus , nucleus ambiguus , hypoglossal nucleus , medial accessory olivary nucleus , dorsal motor nucleus of the vagus , and cuneate nucleus , from P 2 to P 21 in rats . ^^^ Results showed that 1 ) the expression of glutamate increased with age in a majority of the nuclei , whereas that of NMDAR 1 showed heterogeneity among the nuclei ; 2 ) GABA and GABAB expressions decreased with age , whereas that of glycine receptors increased with age ; 3 ) GluR 2 showed two peaks , at P 3 4 and P 12 ; and 4 ) glutamate and NMDAR 1 showed a significant reduction , whereas GABA , GABAB receptors , glycine receptors , and GluR 2 exhibited a concomitant increase at P 12 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We used antibodies against the following proteins and amino acids : the neurotransmitters glutamate and gamma aminobutyric acid ( GABA ) ; the GABA synthesizing enzyme glutamic acid decarboxylase ( GAD ) ; GABA transporter 1 ; the anchoring protein for GABA and glycine receptors , gephyrin ; the calcium binding proteins calbindin and calretinin ; the NR 1 subunit of the N methyl D aspartate glutamate receptor ; the metabotropic glutamate receptors mGluR1alpha , mGluR2 / 3 , and mGluR 5 ; and the intracellular signaling molecules calcineurin , calcium calmodulin kinase IIalpha ( CAMKIIalpha ) and the receptor for inositol triphosphate ( IP3R1alpha ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The resolved 10 ray crystal structures of the glutamate binding domain ( S1 / S2 domains ) of the GluR 2 and NR 1 glutamate receptor subunits were used to model the homologous regions of the N methyl D aspartate ( NMDA ) receptor ' s NR 2 subunits . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The NMDA subtype of glutamate receptors are heteromeric complexes comprised of multiple subunits encoded by at least seven different genes ( NR 1 , NR2A 2D and NR3A 3B ) , and differential expression of these subunits alters the pharmacological and electrophysiological properties of NMDA receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Here we use molecular approaches to identify a ternary combination of exonic UAGG and 5 ' splice site proximal GGGG motifs that functions cooperatively to silence the brain region specific CI cassette exon ( exon 19 ) of the glutamate NMDA R 1 receptor ( GRIN 1 ) transcript . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Given that glutamate and its interaction with dopamine regulate motivational and associative processing in this brain region , we assessed expression of the NR 1 subunit of the N methyl D aspartate ( NMDA ) receptor and the GluR 1 subunit of the alpha amino 3 hydroxy 5 methylisoxazole 4 propionic acid ( AMPA ) receptor in the NAcc core and shell of EE and SI rats . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Real time RT PCR using TaqMan probes was employed to quantify mRNA for proteolipid protein , glyceraldehyde 3 phosphate dehydrogenase , glial fibrillary acidic protein , nestin , and the GluR 2 and NR 1 subunits of glutamate receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
At 30 days after CFA injection , effects of EA on ionotropic glutamate receptor ( NR 1 , NR 2A , GluR 1 and GluR 2 / 3 ) expression in association with c fos and calcitonin gene related peptide ( CGRP ) expression were observed in the dorsal horn of the spinal cord using immunohistochemistry . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Synapses at P 2 contained substantial levels of NR 1 and NR2B and most GluR associated proteins , including SAP 102 , SynGAP , the chain of proteins from GluRs / SAP102 through GKAP / Shank / Homer and metabotropic glutamate receptors , and the adhesion factors , cadherin , catenin , neuroligin , and Nr CAM . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The antagonist bound conformation of the NR2A and NR2B subunits of N methyl D aspartate ( NMDA ) ionotropic glutamate receptor are modeled using the crystal structure of the DCKA ( 5 , 7 dichloro kynurenic acid ) bound form of the NR 1 subunit ligand binding core ( S1S2 ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
To test whether the induction of multiple dopamine signaling molecules in the lateral ganglionic eminence was due to a general enhancement of neuronal differentiation by retinoic acid , we assayed the effects of retinoic acid on other differentiation markers , including glutamate decarboxylase 65 , NR 1 subunit of glutamate NMDA receptor and microtubule associated protein 2 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The N methyl D aspartate family of glutamate receptors ( NMDARs ) are tetrameric cation channels including NR 1 , NR 2 , and possibly NR 3 subunits . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The present study examined whether the hypothalamic expression of three key ionotropic glutamate receptor subunits ( NMDAR 1 , GluR 1 and GluR 6 ) fluctuates significantly on proestrus in the rat , and whether treatment with the antiprogestin , RU 486 affected glutamate receptor subunit expression . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In the absence of exogenous glutamate and glycine , the rate of association of [ 3H ] MK 801 with wild type NR 1 1a / NR2A receptors was considerably slower than that for [ 3H ] dextrorphan . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Using a native chromatin immunoprecipitation assay , we studied histone methylation marks at proximal promoters of 16 ionotropic and metabotropic glutamate receptor genes ( GRIN 1 , 2A D ; GRIA 1 , 3 , 4 ; GRIK 2 , 4 , 5 ; GRM 1 , 3 , 4 , 6 , 7 ) in cerebellar cortex collected across a wide age range from midgestation to 90 years old . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NR 1 protein expression in cultured cortical neurons was specifically reduced by stimulation with 100 microM NMDA or glutamate . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The expression of alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate ( AMPA ) type glutamate ( GluR2 / 3 ) receptors and N methyl D aspartate receptor subtype 1 ( NMDAR 1 ) was carried out by immunohistochemistry , double immunofluorescence and real time RT PCR analysis in the pineal glands of 1 day to 6 wk old rats in the present study . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
They are heteromeric complexes of NR 1 combined with NR2A D and / or NR3A B subunits that are activated by glutamate and glycine and whose activity is modulated by allosteric modulators . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Post anoxic rats showed a reduction in the expression of group 1 metabotropic glutamate receptors ( i . e . mGlu 1 and mGlu 5 receptors ) in the hippocampus and cerebral cortex , whereas expression of the mGlu 2 / 3 receptors , the NR 1 subunit of NMDA receptors , and the GluR 1 subunit of alpha amino 3 hydroxy 5 methylisoxazole 4 propionate ( AMPA ) receptors was unchanged . mGlu 1 and mGlu 5 receptor signalling was also impaired in postanoxic rats , as revealed by a reduced efficacy of the agonist ( 1S , 3R ) 1 Aminocyclopentane 1 , 3 dicarboxylic acid ( 1S , 3R ACPD ) to stimulate polyphosphoinositide hydrolysis in hippocampal slices . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We investigated in the rat the effect of axotomy on the different subunits of excitatory glutamatergic AMPA ( GLuR 1 4 ) , NMDA ( NR 1 , NR2A D ) receptors , post synaptic density 95 , vesicular glutamate transporter 2 , beta catenin and cadherin . mRNA levels and / or protein production were analyzed 1 , 3 , 8 , 30 and 60 days after facial nerve axotomy by in situ hybridization and immunohistofluorescence . mRNAs coding for the GLuR 2 4 , NR 1 , NR2A , B , D subunits of glutamatergic receptors and for post synaptic density 95 , were less abundant after axotomy . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The labeling density for epsilon 2 but not zeta 1 ( NR 1 ) and subtype 2 / 3 glutamate receptor ( GluR2 / 3 ) in Sch CA 1 pyramidal cell synapses was significantly different between the left and right hippocampus with opposite directions in strata oriens and radiatum ; the left to right ratio of epsilon 2 labeling density was 1 : 1 . 50 in stratum oriens and 1 . 44 : 1 in stratum radiatum . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
This unique type of glutamate receptor was reported to be activated by the traditional agonists of all three major glutamate receptor subfamilies [ i . e . , alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate ( AMPA ) , kainate , and N methyl d aspartate ( NMDA ) ] in a glycine dependent as well as magnesium blockable manner and was reported to consist of an NR 1 subunit coexpressed with the kainate binding protein ( KBP ) from Xenopus laevis , XenU 1 . ^^^ Because we verified that XenU 1 is expressed and inserted into the plasma membrane of HEK 293 cells , we conclude that XenU 1 and NR 1 do not form the postulated unitary glutamate receptor . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We performed immunofluorescent double labeling for the NR 1 subunit of the N methyl D aspartate receptor ( NMDAR ) and the vesicular glutamate transporter 1 ( VGLUT 1 ) . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
We show that responses induced by 1mM glutamate in NR 1 1a / NR2A and NR 1 1a / NR2B receptors are potentiated five to eight fold more by pregnenolone sulfate than responses of NR 1 1a / NR2C and NR 1 1a / NR2D receptors with no differences in the concentration of pregnenolone sulfate that produced 50 % potentiation . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
These receptors are heteromeric ion channels that for activation require binding of glycine and glutamate to the NR 1 and NR 2 subunits , respectively . ^^^ Here we report crystal structures of the ligand binding core of NR2A with glutamate and that of the NR 1 NR2A heterodimer with glutamate and glycine . ^^^ The NR2A glutamate complex defines the determinants of glutamate and NMDA recognition , and the NR 1 NR2A heterodimer suggests a mechanism for ligand induced ion channel opening . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Regulation of phosphorylation of NMDA receptor NR 1 subunits in the rat neostriatum by group 1 metabotropic glutamate receptors in vivo . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Developmental gap junction uncoupling and Cx 36 downregulation are not affected by blockade of non NMDA glutamate receptors , and do not occur in hypothalamic neurons from NMDA receptor subunit 1 ( NMDAR 1 ) knockout mice . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
While there were no alterations in the glutamate sensitivity , channel open probability or the single channel conductance of the receptor , a crosslinking assay demonstrated that the NR 1 and NR2A subunits of NMDA receptors were preferentially retained in the cytoplasm after SD , indicating that SD alters NMDAR surface expression . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glutamate exhibited a marginally higher apparent affinity for NR2A containing receptors than NR2B containing receptors , regardless of the NR 1 subunit present . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
In contrast , mutant myosin Vb did not change the localization of several other neurotransmitter receptors , including the glutamate receptor subunit NR 1 . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Sections were processed and analyzed for [ 3H ] glutamate binding to NMDA receptors using receptor autoradiography and for mRNA for the zeta 1 ( NR 1 ) , epsilon 1 ( NR2A ) , and epsilon 2 ( NR2B ) subunits of the NMDA receptor using in situ hybridization . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Identification and localisation of the NR 1 sub unit homologue of the NMDA glutamate receptor in the honeybee brain . ^^^ The NR 1 sub unit homologue of the NMDA glutamate receptor was characterised in the honeybee . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The mRNA and protein expression of endothelial , neuronal , and inducible nitric oxide synthase ( eNOS , nNOS , and iNOS , respectively ) , hypoxia inducible factor 1alpha ( HIF 1alpha ) , vascular endothelial growth factor ( VEGF ) , N methyl D aspartate receptor subunit 1 ( NMDAR 1 ) , and alpha amino 3 hydroxy 5 methyl 4 isoxazole propionic acid glutamate ( AMPA GluR 2 and GluR 3 ) receptors in the retina was determined by real time RT PCR , Western blot analysis , and immunohistochemistry . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
GT 1 7 neurons express mRNAs for various mouse NMDA receptor subunits ( zeta , 1 , epsilon 3 , epsilon 4 , and epsilon 2 , corresponding to the NR 1 , NR2C , NR2D , and NR2B rat subunits ) and increase their spontaneous release of GnRH when incubated in the presence of exogenous glutamate or NMDA . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Neuronal degeneration was paralleled by reduced glutamate receptor ( NR 1 , GluR 1 and GluR6 / 7 ) immunolabeling throughout the whole hippocampal formation . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Cellular studies reveal that the ionotropic glutamate receptors , N methyl D aspartate receptors ( NMDARs ) , can be phosphorylated on their NR 1 subunits at the C terminal serine residues , which is a major mechanism for the regulation of NMDAR functions . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Glutamate , which binds to NR 2 subunits , also binds to NR3A , but with very low affinity ( Kd = 9 . 6 mm ) ; in contrast , binding of glutamate to NR 1 was not detectable even at a 300 mm concentration . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Although Con G is known to bind to the glutamate binding site on the NR 2 subunit of the receptor , it is unclear whether it can allosterically modulate the function of the receptor through the glycine binding site on the NR 1 subunit . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Applying semi quantitative immunoblotting , we found that in the whole tetanized hippocampus , synaptic expression of the N methyl D aspartate and alpha amino 3 hydroxyl 5 methyl 4 isoxazole propionate receptor subunits ( NR 1 , NR2A , glutamate receptor 1 ) and their associated partners , e . g . synaptic associated protein 97 , postsynaptic density protein 95 , alpha subunit of Ca2+ / calmodulin dependent protein kinase 2 , neuronal nitricoxide synthase , increased 180 min post high frequency stimulation . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Phylogenetic analysis suggests that both the AcNR1s and LsNR1s belong to the NR 1 subgroup of ionotrophic glutamate receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Using double immunocytochemistry , we found that rats exhibiting panic like responses ( e . g . , L AG plus lactate ) had increased c Fos immunoreactivity in DMH neurons expressing the NMDA receptor 1 ( NR 1 ) subunit , but not those expressing the glutamate receptor 2 and 3 subunits of the AMPA receptors . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
These studies indeed showed that in EGC cultures , mRNA of the glutamate receptor subunits NR 1 , NR2A / B , GluR 1 , GluR 3 , and GluR 5 and the protein bands of the glutamate receptor subunits NR2A / B , GluR 1 , GluR 3 , and GluR 5 could be detected . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Detection of the phosphorylation of cAMP response element binding protein ( pCREB ) revealed that a subset of NR 1 positive hNPC could respond to glutamate . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
N Methyl D aspartate receptor subunit genes ( gene symbol , GRIN ) GRIN 1 , GRIN2A , GRIN2B , GRIN2C , and GRIN2D have been assigned to chromosomes ( Chr ) 3 , 10 , 4 , 10 , and 1 , respectively . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Film autoradiograms demonstrated a distinctive laminar distribution of hybridization signals for each of the probes recognizing NMDAR 1 , NMDAR2A , and NMDAR2B messenger RNA ; hybridization with probes for NMDAR2C and NMDAR2D resulted in scattered signals without laminar organization . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Expression of NMDAR2D glutamate receptor subunit mRNA in neurochemically identified interneurons in the rat neostriatum , neocortex and hippocampus . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Purkinje cells showed very dense labeling for NMDAR 1 mRNA , dense labeling for NMDAR2A mRNA , and moderate labeling for NMDAR2D mRNA , whereas labeling for NMDAR2C mRNA was low . ^^^ Granule cells showed high hybridization signals for the NMDAR 1 and NMDAR2C mRNAs and moderate signals for the NMDAR2A and NMDAR2D mRNAs . ^^^ Neurons in the molecular layer , i . e . , basket cells and stellate cells , showed moderate hybridization signals for NMDAR 1 and NMDAR2D and low signal for NMDAR2C . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
Northern blotting and reverse transcriptase polymerase chain reaction ( RT PCR ) studies identified expression of NMDAR 1 and NMDAR2D type subunit mRNA in rat marrow , human megakaryocytes , and MEG 01 clonal megakaryoblastic cells . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
The mRNA expression of the subunits of rat hippocampus NMDAR NMDAR 1 , NMDAR2A , NMDAR2B , NMDAR2D was determined with RT PCR technique in C group and at 0 . 5 , 1 , 2 and 4 postburn hours ( PBHs ) in S group . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
At the mRNA level , we found expression of only the constant NMDAR 1 as well as the subtype NMDAR2D . ^^^
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
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Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA
Interacting proteins: O15399 and Q05586	Pubmed	SVM Score :0.0
NA