Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.54837429
RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD 51 . 0.54837429^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.75111924
Point mutations in this region of RAD51C altered its interaction with both XRCC 3 and RAD51B in a two hybrid system . 0.75111924^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
In mammalian cells , five genes in this family have been identified ( HsRAD 51 , XRCC 2 , XRCC 3 , RAD51B / hREC2 and HsDMC 1 ) , and here we report the isolation of the sixth member , RAD51C . ^^^ Yeast two hybrid experiments indicate that the Rad51C protein binds to two other members of the Rad 51 protein family ( Xrcc 3 and Rad51B ) but not to itself . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
The new genes ( R51H2 and R51H3 ) were mapped to human chromosomes 14q23 24 and 17q1 . 2 , respectively . ^^^ Expression studies showed that R51H2 is expressed at lower levels than R51H3 , but that expression of both genes occurs at elevated levels in the testis compared with other tissues . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Five human Rad 51 paralogs have been identified ( XRCC 2 , XRCC 3 , Rad51B / Rad51L1 , Rad51C / Rad51L2 , and Rad51D / Rad51L3 ) , and each interacts with one or more of the others . ^^^ Previously we reported that HsRad 51 interacts with XRCC 3 , and Rad51C interacts with XRCC 3 , Rad51B , and HsRad 51 . ^^^ For example , Rad51B expression enhances the binding of Rad51C to XRCC 3 and to HsRad51D , and Rad51C expression allows the indirect interaction of Rad51B with Rad51D . ^^^ Experiments using 6xHis tagged proteins in the baculovirus system confirm several of our yeast results , including Rad51B interaction with Rad51D only when Rad51C is simultaneously expressed and Rad51C interaction with XRCC 2 only when Rad51D is present . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Five paralogs of RAD 51 , known as RAD51B , RAD51C , RAD51D , XRCC 2 , and XRCC 3 , have been identified and also shown to be required for recombination and genome stability . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Cells defective in any of the RAD 51 paralogs ( RAD51B , RAD51C , RAD51D , XRCC 2 , and XRCC 3 ) are sensitive to DNA cross linking agents and to ionizing radiation . ^^^ Here , we show that the five paralogs exist in two distinct complexes in human cells : one contains RAD51B , RAD51C , RAD51D , and XRCC 2 ( defined as BCDX 2 ) , whereas the other consists of RAD51C with XRCC 3 . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Mediator function of the human Rad51B Rad51C complex in Rad51 / RPA catalyzed DNA strand exchange . ^^^ We show that two of them , Rad51B and Rad51C , are associated in a stable complex . ^^^ Rad51B Rad51C complex has ssDNA binding and ssDNA stimulated ATPase activities . ^^^ We also examined the functional interaction of Rad51B Rad51C with Rad 51 and RPA . ^^^ The competition by RPA for substrate binding can be partially alleviated by Rad51B Rad51C . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Homologous recombinational repair of DNA double strand breaks and crosslinks in human cells is likely to require Rad 51 and the five Rad 51 paralogs ( XRCC 2 , XRCC 3 , Rad51B / Rad51L1 , Rad51C / Rad51L2 and Rad51D / Rad51L3 ) , as has been shown in chicken and rodent cells . ^^^ In addition , we find that Rad51C , but not XRCC 3 , interacts directly or indirectly with Rad51B , Rad51D and XRCC 2 . ^^^ These results argue that there are at least two complexes of Rad 51 paralogs in human cells ( Rad51C XRCC 3 and Rad51B Rad51C Rad51D XRCC 2 ) , both containing Rad51C . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Genetic studies in rodent and chicken mutant cell lines have suggested that Rad 51 paralogs ( XRCC 2 , XRCC 3 , Rad51B / Rad51L1 , Rad51C / Rad51L2 and Rad51D / Rad51L3 ) play important roles in homologous recombinational repair of DNA double strand breaks and in maintaining chromosome stability . ^^^ In addition , Rad51B could be pulled down with Rad51C and Rad51D , but not with XRCC 3 . ^^^ These results suggest that Rad51C is involved in two distinct in vivo complexes : Rad51B Rad51C Rad51D XRCC 2 and Rad51C XRCC 3 . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro . ^^^ In addition to Rad 51 protein , five paralogs have been identified : Rad51B / Rad51L1 , Rad51C / Rad51L2 , Rad51D / Rad51L3 , XRCC 2 , and XRCC 3 . ^^^ To further characterize a subset of these proteins , recombinant Rad 51 , Rad51B ( His ) ( 6 ) , and Rad51C proteins were individually expressed employing the baculovirus system , and each was purified from Sf 9 insect cells . ^^^ Rad51B and Rad51C proteins were found to bind single and double stranded DNA and to preferentially bind 3 ' end tailed double stranded DNA . ^^^ The ability to bind DNA was elevated with mixed Rad 51 and Rad51C , as well as with mixed Rad51B and Rad51C , compared with that of the individual protein . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Here we demonstrate that the DNA repair protein RAD51B , and not its cognate partner RAD51C , interacts with histones and not nucleosomes . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
These proteins have been found to form two distinct complexes in vivo , Rad51B Rad51C Rad51D Xrcc 2 ( BCDX 2 ) and Rad51C Xrcc 3 ( CX 3 ) . ^^^ The models of the human Rad51B , Rad51C , Xrcc 3 and murine Rad51D ( mRad51D ) proteins reveal distinct N terminal and C terminal domains connected by a linker region . ^^^ Using yeast two hybrid and co immunoprecipitation techniques , we have demonstrated that a fragment of Rad51B containing amino acid residues 1 75 interacts with the C terminus and linker of Rad51C , residues 79 376 , and this region of Rad51C also interacts with mRad51D and Xrcc 3 . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Rad 51 like proteins have been identified from yeast ( Rad 55 , Rad 57 and Dmc 1 ) to vertebrates ( Rad51B , Rad51C , Rad51D , Xrcc 2 , Xrcc 3 and Dmc 1 ) . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
The formation of RAD 51 foci in response to DNA damage is dependent upon BRCA 2 and a series of proteins known as the RAD 51 paralogues ( RAD51B , RAD51C , RAD51D , XRCC 2 and XRCC 3 ) , indicating that the components present within foci assemble in a carefully orchestrated and ordered manner . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
The five RAD 51 paralogs ( RAD51B , RAD51C , RAD51D , XRCC 2 , and XRCC 3 ) are required in mammalian cells for normal levels of genetic recombination and resistance to DNA damaging agents . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Preferential binding to branched DNA strands and strand annealing activity of the human Rad51B , Rad51C , Rad51D and Xrcc 2 protein complex . ^^^ The Rad51B , Rad51C , Rad51D and Xrcc 2 proteins are Rad 51 paralogs , and form a complex ( BCDX 2 complex ) in mammalian cells . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Similarly , human RAD 51 paralogues , including RAD51B , RAD51C , RAD51D , XRCC 2 , XRCC 3 and DMC 1 , are not predicted to bind the BRC repeat . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
The disruption of the Rad 54 , Rad51B , Rad51C , Rad51D , Xrcc 2 and Xrcc 3 genes resulted in a dramatic reduction of spontaneous and MMC induced SCEs . ^^^ These observations indicate that DNA double strand breaks ( DSB ) at stalled replication forks and those arising as repair intermediates present strong signals to cell death but can be tolerated by the HR repair pathway , where Rad 54 , Rad51B and Rad51C have an initiative role and repair can be completed by their paralogs Rad51D , Xrcc 2 and Xrcc 3 . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
In vertebrates , five Rad 51 paralogs ( Rad51B , Rad51C , Rad51D , XRCC 2 , and XRCC 3 ) are expressed in mitotically growing cells and are thought to play mediating roles in homologous recombination , although their precise functions remain unclear . ^^^ Among the five paralogs , Rad51C was found to be a central component present in two complexes , Rad51C XRCC 3 and Rad51B Rad51C Rad51D XRCC 2 . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Formation of DNA damaged induced nuclear Rad 51 foci requires Xrcc 3 and the other Rad 51 paralog proteins ( Rad51B , Rad51C , Rad51D , Xrcc 2 ) , thus supporting a model in which an early function of Xrcc 3 involves promoting assembly of active Rad 51 repair complexes . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Comparison of the characteristics of brca2tr cells with those of other HR deficient DT 40 clones revealed marked similarities with rad 51 paralog mutants ( rad51b , rad51c , rad51d , xrcc 2 , or xrcc 3 cells ) . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Nuclear localization of Rad51B is independent of Rad51C and BRCA 2 . ^^^ Rad51B is one of the five paralogs of human Rad 51 and is found in a multiprotein complex with three other Rad 51 paralogs , Rad51C , Rad51D and Xrcc 2 . ^^^ Participation of Rad51B in this complex depends on its direct interaction with Rad51C . ^^^ Examination of wild type EGFP Rad51B fusion protein in hamster irs 3 mutant cells , deficient in Rad51C , showed that Rad51B localizes to the nucleus independently of Rad51C , the only known direct binding partner for Rad51B . ^^^ This study finds that a KKLK motif in the N terminus of Rad51B serves as an NLS that allows Rad51B to localize to the nucleus independent of Rad51C or BRCA2 . . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
In mitotically dividing vertebrate cells , the primary proteins involved in homologous recombination repair are RAD 51 and the five RAD 51 paralogs , RAD51B , RAD51C , RAD51D , XRCC 2 , and XRCC 3 . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
These include five Rad 51 paralogs , Rad51B , Rad51C , Rad51D , XRCC 2 and XRCC 3 . ^^^ However , this idea was challenged by the biochemical identification of two independent complexes composed of either Rad51B / C / D / XRCC2 or Rad51C / XRCC3 . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
In mammals , HR requires the activities of the RAD 51 family ( RAD 51 , RAD51B , RAD51C , RAD51D , XRCC 2 , XRCC 3 and DMC 1 ) , each of which contains conserved ATP binding sequences ( Walker Motifs A and B ) . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
The RAD 51 paralogs ( RAD51B , RAD51C , RAD51D , XRCC 2 and XRCC 3 ) play important roles in this process . ^^^ In this study , we show that human RAD 51 interacts with RAD51C XRCC 3 or RAD51B C D XRCC 2 . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
In vertebrates , homologous recombinational repair ( HRR ) requires RAD 51 and five RAD 51 paralogs ( XRCC 2 , XRCC 3 , RAD51B , RAD51C and RAD51D ) that all contain conserved Walker A and B ATPase motifs . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
The Rad 51 like proteins , Rad51B , Rad51C , Rad51D , XRCC 2 , and XRCC 3 , have been shown to form two distinct complexes and seem to assist Rad 51 in the early stages of homologous recombination . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
However , many archaeal species have two recA / RAD51 homologs ( RADA and RADB ) , and eukaryotes possess multiple members ( RAD 51 , RAD51B , RAD51C , RAD51D , DMC 1 , XRCC 2 , XRCC 3 , and recA ) . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
Very recently , a number of RAD 51 like genes have been identified in mammals , either through cloning genes complementing cell lines sensitive to DNA damaging agents ( XRCC 2 , XRCC 3 ) , or through homology searches ( RAD51L1 , RAD51L2 , RAD51L3 ) . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
The RAD 51 family of genes , including RAD 51 and the five RAD 51 like genes ( XRCC 2 , XRCC 3 , RAD51L1 , RAD51L2 , RAD51L3 ) are known to have crucial non redundant roles in this pathway . ^^^
Interacting proteins: O15315 and O43502	Pubmed	SVM Score :0.0
NA
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.54837429
RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD 51 . 0.54837429^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.75111924
Point mutations in this region of RAD51C altered its interaction with both XRCC 3 and RAD51B in a two hybrid system . 0.75111924^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
The new genes ( R51H2 and R51H3 ) were mapped to human chromosomes 14q23 24 and 17q1 . 2 , respectively . ^^^ Expression studies showed that R51H2 is expressed at lower levels than R51H3 , but that expression of both genes occurs at elevated levels in the testis compared with other tissues . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
In mammalian cells , five genes in this family have been identified ( HsRAD 51 , XRCC 2 , XRCC 3 , RAD51B / hREC2 and HsDMC 1 ) , and here we report the isolation of the sixth member , RAD51C . ^^^ Yeast two hybrid experiments indicate that the Rad51C protein binds to two other members of the Rad 51 protein family ( Xrcc 3 and Rad51B ) but not to itself . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Five human Rad 51 paralogs have been identified ( XRCC 2 , XRCC 3 , Rad51B / Rad51L1 , Rad51C / Rad51L2 , and Rad51D / Rad51L3 ) , and each interacts with one or more of the others . ^^^ Previously we reported that HsRad 51 interacts with XRCC 3 , and Rad51C interacts with XRCC 3 , Rad51B , and HsRad 51 . ^^^ For example , Rad51B expression enhances the binding of Rad51C to XRCC 3 and to HsRad51D , and Rad51C expression allows the indirect interaction of Rad51B with Rad51D . ^^^ Experiments using 6xHis tagged proteins in the baculovirus system confirm several of our yeast results , including Rad51B interaction with Rad51D only when Rad51C is simultaneously expressed and Rad51C interaction with XRCC 2 only when Rad51D is present . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Five paralogs of RAD 51 , known as RAD51B , RAD51C , RAD51D , XRCC 2 , and XRCC 3 , have been identified and also shown to be required for recombination and genome stability . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Cells defective in any of the RAD 51 paralogs ( RAD51B , RAD51C , RAD51D , XRCC 2 , and XRCC 3 ) are sensitive to DNA cross linking agents and to ionizing radiation . ^^^ Here , we show that the five paralogs exist in two distinct complexes in human cells : one contains RAD51B , RAD51C , RAD51D , and XRCC 2 ( defined as BCDX 2 ) , whereas the other consists of RAD51C with XRCC 3 . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Mediator function of the human Rad51B Rad51C complex in Rad51 / RPA catalyzed DNA strand exchange . ^^^ We show that two of them , Rad51B and Rad51C , are associated in a stable complex . ^^^ Rad51B Rad51C complex has ssDNA binding and ssDNA stimulated ATPase activities . ^^^ We also examined the functional interaction of Rad51B Rad51C with Rad 51 and RPA . ^^^ The competition by RPA for substrate binding can be partially alleviated by Rad51B Rad51C . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Homologous recombinational repair of DNA double strand breaks and crosslinks in human cells is likely to require Rad 51 and the five Rad 51 paralogs ( XRCC 2 , XRCC 3 , Rad51B / Rad51L1 , Rad51C / Rad51L2 and Rad51D / Rad51L3 ) , as has been shown in chicken and rodent cells . ^^^ In addition , we find that Rad51C , but not XRCC 3 , interacts directly or indirectly with Rad51B , Rad51D and XRCC 2 . ^^^ These results argue that there are at least two complexes of Rad 51 paralogs in human cells ( Rad51C XRCC 3 and Rad51B Rad51C Rad51D XRCC 2 ) , both containing Rad51C . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Genetic studies in rodent and chicken mutant cell lines have suggested that Rad 51 paralogs ( XRCC 2 , XRCC 3 , Rad51B / Rad51L1 , Rad51C / Rad51L2 and Rad51D / Rad51L3 ) play important roles in homologous recombinational repair of DNA double strand breaks and in maintaining chromosome stability . ^^^ In addition , Rad51B could be pulled down with Rad51C and Rad51D , but not with XRCC 3 . ^^^ These results suggest that Rad51C is involved in two distinct in vivo complexes : Rad51B Rad51C Rad51D XRCC 2 and Rad51C XRCC 3 . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro . ^^^ In addition to Rad 51 protein , five paralogs have been identified : Rad51B / Rad51L1 , Rad51C / Rad51L2 , Rad51D / Rad51L3 , XRCC 2 , and XRCC 3 . ^^^ To further characterize a subset of these proteins , recombinant Rad 51 , Rad51B ( His ) ( 6 ) , and Rad51C proteins were individually expressed employing the baculovirus system , and each was purified from Sf 9 insect cells . ^^^ Rad51B and Rad51C proteins were found to bind single and double stranded DNA and to preferentially bind 3 ' end tailed double stranded DNA . ^^^ The ability to bind DNA was elevated with mixed Rad 51 and Rad51C , as well as with mixed Rad51B and Rad51C , compared with that of the individual protein . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Similarly , human RAD 51 paralogues , including RAD51B , RAD51C , RAD51D , XRCC 2 , XRCC 3 and DMC 1 , are not predicted to bind the BRC repeat . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Preferential binding to branched DNA strands and strand annealing activity of the human Rad51B , Rad51C , Rad51D and Xrcc 2 protein complex . ^^^ The Rad51B , Rad51C , Rad51D and Xrcc 2 proteins are Rad 51 paralogs , and form a complex ( BCDX 2 complex ) in mammalian cells . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
The disruption of the Rad 54 , Rad51B , Rad51C , Rad51D , Xrcc 2 and Xrcc 3 genes resulted in a dramatic reduction of spontaneous and MMC induced SCEs . ^^^ These observations indicate that DNA double strand breaks ( DSB ) at stalled replication forks and those arising as repair intermediates present strong signals to cell death but can be tolerated by the HR repair pathway , where Rad 54 , Rad51B and Rad51C have an initiative role and repair can be completed by their paralogs Rad51D , Xrcc 2 and Xrcc 3 . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
In vertebrates , five Rad 51 paralogs ( Rad51B , Rad51C , Rad51D , XRCC 2 , and XRCC 3 ) are expressed in mitotically growing cells and are thought to play mediating roles in homologous recombination , although their precise functions remain unclear . ^^^ Among the five paralogs , Rad51C was found to be a central component present in two complexes , Rad51C XRCC 3 and Rad51B Rad51C Rad51D XRCC 2 . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Formation of DNA damaged induced nuclear Rad 51 foci requires Xrcc 3 and the other Rad 51 paralog proteins ( Rad51B , Rad51C , Rad51D , Xrcc 2 ) , thus supporting a model in which an early function of Xrcc 3 involves promoting assembly of active Rad 51 repair complexes . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Here we demonstrate that the DNA repair protein RAD51B , and not its cognate partner RAD51C , interacts with histones and not nucleosomes . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
These proteins have been found to form two distinct complexes in vivo , Rad51B Rad51C Rad51D Xrcc 2 ( BCDX 2 ) and Rad51C Xrcc 3 ( CX 3 ) . ^^^ The models of the human Rad51B , Rad51C , Xrcc 3 and murine Rad51D ( mRad51D ) proteins reveal distinct N terminal and C terminal domains connected by a linker region . ^^^ Using yeast two hybrid and co immunoprecipitation techniques , we have demonstrated that a fragment of Rad51B containing amino acid residues 1 75 interacts with the C terminus and linker of Rad51C , residues 79 376 , and this region of Rad51C also interacts with mRad51D and Xrcc 3 . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Rad 51 like proteins have been identified from yeast ( Rad 55 , Rad 57 and Dmc 1 ) to vertebrates ( Rad51B , Rad51C , Rad51D , Xrcc 2 , Xrcc 3 and Dmc 1 ) . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
The formation of RAD 51 foci in response to DNA damage is dependent upon BRCA 2 and a series of proteins known as the RAD 51 paralogues ( RAD51B , RAD51C , RAD51D , XRCC 2 and XRCC 3 ) , indicating that the components present within foci assemble in a carefully orchestrated and ordered manner . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
The five RAD 51 paralogs ( RAD51B , RAD51C , RAD51D , XRCC 2 , and XRCC 3 ) are required in mammalian cells for normal levels of genetic recombination and resistance to DNA damaging agents . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
The Rad 51 like proteins , Rad51B , Rad51C , Rad51D , XRCC 2 , and XRCC 3 , have been shown to form two distinct complexes and seem to assist Rad 51 in the early stages of homologous recombination . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
However , many archaeal species have two recA / RAD51 homologs ( RADA and RADB ) , and eukaryotes possess multiple members ( RAD 51 , RAD51B , RAD51C , RAD51D , DMC 1 , XRCC 2 , XRCC 3 , and recA ) . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Very recently , a number of RAD 51 like genes have been identified in mammals , either through cloning genes complementing cell lines sensitive to DNA damaging agents ( XRCC 2 , XRCC 3 ) , or through homology searches ( RAD51L1 , RAD51L2 , RAD51L3 ) . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Comparison of the characteristics of brca2tr cells with those of other HR deficient DT 40 clones revealed marked similarities with rad 51 paralog mutants ( rad51b , rad51c , rad51d , xrcc 2 , or xrcc 3 cells ) . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
Nuclear localization of Rad51B is independent of Rad51C and BRCA 2 . ^^^ Rad51B is one of the five paralogs of human Rad 51 and is found in a multiprotein complex with three other Rad 51 paralogs , Rad51C , Rad51D and Xrcc 2 . ^^^ Participation of Rad51B in this complex depends on its direct interaction with Rad51C . ^^^ Examination of wild type EGFP Rad51B fusion protein in hamster irs 3 mutant cells , deficient in Rad51C , showed that Rad51B localizes to the nucleus independently of Rad51C , the only known direct binding partner for Rad51B . ^^^ This study finds that a KKLK motif in the N terminus of Rad51B serves as an NLS that allows Rad51B to localize to the nucleus independent of Rad51C or BRCA2 . . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
In mitotically dividing vertebrate cells , the primary proteins involved in homologous recombination repair are RAD 51 and the five RAD 51 paralogs , RAD51B , RAD51C , RAD51D , XRCC 2 , and XRCC 3 . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
These include five Rad 51 paralogs , Rad51B , Rad51C , Rad51D , XRCC 2 and XRCC 3 . ^^^ However , this idea was challenged by the biochemical identification of two independent complexes composed of either Rad51B / C / D / XRCC2 or Rad51C / XRCC3 . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
In mammals , HR requires the activities of the RAD 51 family ( RAD 51 , RAD51B , RAD51C , RAD51D , XRCC 2 , XRCC 3 and DMC 1 ) , each of which contains conserved ATP binding sequences ( Walker Motifs A and B ) . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
The RAD 51 paralogs ( RAD51B , RAD51C , RAD51D , XRCC 2 and XRCC 3 ) play important roles in this process . ^^^ In this study , we show that human RAD 51 interacts with RAD51C XRCC 3 or RAD51B C D XRCC 2 . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
In vertebrates , homologous recombinational repair ( HRR ) requires RAD 51 and five RAD 51 paralogs ( XRCC 2 , XRCC 3 , RAD51B , RAD51C and RAD51D ) that all contain conserved Walker A and B ATPase motifs . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
The RAD 51 family of genes , including RAD 51 and the five RAD 51 like genes ( XRCC 2 , XRCC 3 , RAD51L1 , RAD51L2 , RAD51L3 ) are known to have crucial non redundant roles in this pathway . ^^^
Interacting proteins: O43502 and O15315	Pubmed	SVM Score :0.0
NA