| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| Amplification and overexpression of the MDM 4 ( MDMX ) gene from 1q32 in a subset of malignant gliomas without TP 53 mutation or MDM 2 amplification . ^^^ |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| MDMX is a p 53 binding protein , which shares a high degree of homology with MDM 2 , a negative regulator of the tumor suppressor p 53 . ^^^ |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| It has been well documented that Mdm 2 and its homologue MdmX not only are critical negative regulators of the tumor suppressor p 53 but that both Mdm 2 and MdmX interact to affect the function of the other . ^^^ |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| It has been shown that MDMX inhibits the activity of the tumor suppressor p 53 by primarily cooperating with the p 53 feedback regulator MDM 2 . ^^^ |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| Rescue of embryonic lethality in Mdm 4 null mice by loss of Trp 53 suggests a nonoverlapping pathway with MDM 2 to regulate p 53 . ^^^ To assess the importance of p 53 in the death of Mdm 4 / embryos , we crossed in the Trp 53 null allele . ^^^ The loss of Trp 53 completely rescued the Mdm 4 / embryonic lethality . ^^^ |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| Absence of Mdm 4 expression results in embryonic lethality ( 10 . 5 days postcoitum [ dpc ] ) , which was rescued by transferring the Mdm 4 mutation into a Trp 53 null background . ^^^ These findings unambiguously assign a critical role for Mdm 4 as a negative regulator of p 53 and suggest that Mdm 4 could contribute to neoplasias retaining wild type Trp 53 . ^^^ |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| Mdm 2 and its homolog Mdm 4 inhibit the function of the tumor suppressor p 53 . ^^^ |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| Adenoviral E1A targets Mdm 4 to stabilize tumor suppressor p 53 . ^^^ |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| Quantitative RT PCR was employed to verify the profiling findings , and also used to examine a number of drug resistance related candidate genes ( MDR 1 , MRP 1 , MGMT , PTEN , BCL 2 , BAX , TP 53 and P 21 ) . ^^^ |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15151 and P04637 |
Pubmed |
SVM Score :0.0 |
| NA |
|