Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
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Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 2 , a natural antagonist for Tie 2 that disrupts in vivo angiogenesis . ^^^ An Ang 1 relative , termed angiopoietin 2 ( Ang 2 ) , was identified by homology screening and shown to be a naturally occurring antagonist for Ang 1 and Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 2 is a new member of the family of the ligands of Tek ( Tie 2 ) , a transmembrane receptor with tyrosine kinase activity which is specifically expressed in endothelial cells during angiogenesis . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Fibroblasts stably transfected with Tie 2 receptor exhibit chemotactic responses for both angiopoietin 1 and angiopoietin 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Tie 2 receptor ligands , angiopoietin 1 and angiopoietin 2 , modulate VEGF induced postnatal neovascularization . ^^^ Angiopoietin 2 ( Ang 2 ) was found to disrupt blood vessel formation in the developing embryo by antagonizing the effects of Ang 1 and Tie 2 and was thus considered to represent a natural Ang1 / Tie2 inhibitor . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 2 also induced a low level of TEK phosphorylation and weakened the phosphorylation induced by Angiopoietin 1 , suggestive of an elaborate regulator of the TEK TEK ligand signaling pathway . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 2 ( Ang 2 ) is a ligand for the endothelial cell tyrosine kinase receptor Tie 2 and counteracts blood vessel maturation / stability mediated by angiopoietin 1 ( Ang 1 ) , the other known ligand of Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
BACKGROUND : Angiopoietin 1 ( Ang 1 ) and angiopoietin 2 ( Ang 2 ) have recently been identified as ligands for the endothelial cell specific Tie 2 receptor . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
To assess the potential role of Tie 2 and its ligands angiopoietin 1 and angiopoietin 2 in tumor vascularization , we analyzed their expression pattern in human gliomas . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
An in vitro study revealed that Angiopoietin 1 but not Angiopoietin 2 promoted the adhesion to fibronectin ( FN ) through integrins in TIE 2 transfected cells and primary TIE2+ cells sorted from 9 . 5 d . p . c . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The angiopoietins include a naturally occurring agonist , angiopoietin 1 , as well as a naturally occurring antagonist , angiopoietin 2 , both of which act by means of the Tie 2 receptor . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The complex process of angiogenesis is controlled by the vascular endothelial growth factor ( VEGF ) and its receptors and by the recently isolated angiopoietin 1 ( Ang 1 ) and angiopoietin 2 ( Ang 2 ) that signal through the transmembrane endothelial receptor tyrosine kinase Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Expression of angiopoietin 1 , angiopoietin 2 , and the Tie 2 receptor tyrosine kinase during mouse kidney maturation . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The expression patterns of Angiopoietin 2 ( the natural antagonist for the angiogenic Tie 2 receptor ) and vascular endothelial growth factor ( VEGF ) strongly implicate these factors in the above processes . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Compared to normal tissues , in thyroid neoplasias we observed a consistent increase in vascular endothelial growth factor ( VEGF ) , VEGF C , and angiopoietin 2 and in their tyrosine kinase receptors KDR , Flt 4 , and Tek . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Tie 2 and angiopoietin 2 expression at the fetal maternal interface : a receptor ligand model for vascular remodelling . ^^^ Interaction between the endothelial cell receptor , Tie 2 , and its recently discovered antagonist ligand , angiopoietin 2 ( Ang 2 ) , has been implicated in the loosening of vessel structure . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The temporal expression of angiopoietin 1 ( Angpo 1 ) , angiopoietin 2 ( Angpo 2 ) , Tie 1 , and Tie 2 mRNA was studied in a focal cerebral ischemia model in rats . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 2 ( Ang 2 ) disrupts blood vessel formation in the developing embryo by antagonizing the effects of angiopoietin 1 ( Ang 1 ) on the Tie 2 receptor . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 2 ( Ang 2 ) is a naturally occurring antagonist of angiopoietin 1 ( Ang 1 ) that competes for binding to the Tie 2 receptor and blocks Ang 1 induced Tie 2 autophosphorylation during vasculogenesis . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
In an effort to determine whether the angiopoietins and Tie receptors play a role in the pathobiology of angiosarcoma and KS , we studied the expression of angiopoietin 1 , angiopoietin 2 , angiopoietin 4 , Tie 1 , and Tie 2 mRNAs in biopsies of KS from 12 AIDS patients , in biopsies of cutaneous angiosarcoma from two patients , and in control biopsies of normal skin from three volunteers by in situ hybridization . ^^^ Strong expression of angiopoietin 2 , Tie 1 , and Tie 2 mRNAs was detected in the tumor cells of KS and cutaneous angiosarcomas , in contrast to the focal low level expression in normal skin biopsies . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 and angiopoietin 2 activate trophoblast Tie 2 to promote growth and migration during placental development . ^^^ As Tie 2 ( ( / ) ) mice exhibit growth retardation and vascular network malformation , the expression of Tie 2 and its ligands , angiopoietin 1 ( Ang 1 ) and angiopoietin 2 ( Ang 2 ) , were investigated in human placenta from normal pregnancies and those complicated by severe IUGR . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Expression of Tie 2 , angiopoietin 1 , angiopoietin 2 , ephrinB 2 and EphB 4 in pyogenic granuloma of human gingiva implicates their roles in inflammatory angiogenesis . ^^^ Tie 2 , angiopoietin 1 ( Ang 1 ) , angiopoietin 2 ( Ang 2 ) , ephrin B 2 and Eph B 4 are all important vascular morphogenesis factors which exhibit their functions in angiogenesis and blood vessel remodeling in embryonic stage . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Hypoxia up regulates angiopoietin 2 , a Tie 2 ligand , in mouse mesangial cells . ^^^ Our previous studies demonstrated angiopoietin 2 ( Ang 2 ) promoter activity in vivo in maturing kidney vascular smooth muscle and mesangial cells , with Tie 2 expressed by adjacent endothelia , including glomerular capillaries . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
BACKGROUND : Angiopoietin 1 and angiopoietin 2 are antagonist angiogenic factors acting via the same receptor Tie 2 . ^^^ MATERIAL AND METHODS : Using immunohistochemistry , localization of angiopoietin 1 , angiopoietin 2 and their receptor Tie 2 was studied in normal human prostate and PCa . ^^^ RESULTS : Few epithelial cells of normal prostate expressed angiopoietin 1 and Tie 2 but not angiopoietin 2 . ^^^ Additionally , angiopoietin 2 was expressed in smooth muscle cells of intratumoral blood vessels which also exhibited Tie 2 . ^^^ CONCLUSIONS : The results presented indicate a role of angiopoietin Tie 2 system , particularly of angiopoietin 2 in the vascularization of PCa . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 induces Tie 2 signaling as a receptor activator and maintains blood vessel formation , whereas angiopoietin 2 destabilizes vessels by blocking Tie 2 signaling as an antagonist of angiopoietin 1 and acts with vascular endothelial growth factor to initiate angiogenesis . ^^^ Angiopoietin 1 , angiopoietin 2 , and Tie 2 were upregulated in involved psoriasis skin compared to uninvolved psoriasis skin , healthy skin , and chronic spongiotic dermatitis skin . ^^^ Vascular endothelial growth factor and basic fibroblast growth factor , which were overexpressed in involved psoriasis skin , enhanced angiopoietin 2 and Tie 2 expression in dermal microvascular endothelial cell cultures . ^^^ Thus , our findings suggest that upregulation of angiopoietin 1 , angiopoietin 2 , and Tie 2 is closely associated with the development of microvascular proliferation in psoriasis , and that the angiopoietin Tie 2 system may act coordinately with vascular endothelial growth factor and basic fibroblast growth factor to promote neovascularization in psoriasis . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
We conclude that in vivo hypoxia exerts inhibitory effects on the activity of the angiopoietin 1 / Tie 2 receptor pathway through reduction of angiopoietin 1 and upregulation of angiopoietin 2 and 3 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 , angiopoietin 2 and Tie 2 in tumour and non tumour tissues during growth of experimental melanoma . ^^^ Angiopoietin 1 ( Ang 1 ) , angiopoietin 2 ( Ang 2 ) and their tyrosine kinase receptor Tie 2 have been shown to play an important role in the processes of growth and remodelling of normal as well as tumour vessels . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Increased Tie 2 expression , enhanced response to angiopoietin 1 , and dysregulated angiopoietin 2 expression in hemangioma derived endothelial cells . ^^^ KDR , Flt 1 , Tie 1 , Tie 2 , and angiopoietin 2 ( Ang 2 ) were strongly expressed in cultured hemangioma derived endothelial cells and in hemangioma tissue . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
BACKGROUND : Angiopoietin 1 ( Ang 1 ) and its antagonist angiopoietin 2 ( Ang 2 ) act on the endothelial cell Tie 2 receptor to regulate vascular integrity and remodeling . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 ( Ang 1 ) promotes vascular maturation via the Tie 2 receptor , while angiopoietin 2 ( Ang 2 ) is its natural antagonist that destabilizes vessels and initiates neovascularization in the presence of vascular endothelial growth factor . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
In addition , they strongly expressed angiopoietin 1 ( Ang 1 ) but not angiopoietin 2 , Tie 1 , or Tie 2 ; in contrast , dermal microvascular endothelial cells exhibited a reciprocal expression pattern . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Hypoxia induced expression of NERF 2 and Tie 2 was blocked by angiopoietin 2 , a competitive inhibitor of angiopoietin 1 , and by recombinant soluble extracellular domain of Tie 2 but not by VEGF neutralizing antibodies . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Using an ovine model of PI IUGR we have observed changes in the expression of vascular endothelial growth factor , placental growth factor , their common receptors , as well as angiopoietin 2 and its receptor , Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Expression of angiopoietin 1 , angiopoietin 2 , and Tie 2 genes in normal ovary with corpus luteum and in ovarian cancer . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
AIM : To study the expressions of vascular endothelial growth factor ( VEG F ) , angiopoietin 1 ( Ang 1 ) , angiopoietin 2 ( Ang 2 ) , Tie 1 , and Tie 2 in C57BL / 6 mouse brain after permanent focal cerebral ischemia . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 has recently been shown to stabilize EC networks by binding to the EC specific tyrosine kinase receptor Tie 2 ; in contrast , angiopoietin 2 is antagonistic to angiopoietin 1 and destabilizes EC networks . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Western blot analyses showed that HBO enhanced the expression of angiopoietin 2 ( Ang 2 ) with no effect on the expression of Tie 2 , angiopoietin 1 , and VEGF . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
While Angiopoietin 1 obligately activates its Tie 2 receptor , Angiopoietin 2 can activate Tie 2 on some cells , while it blocks Tie 2 activation on others . ^^^ Genetic rescue with Angiopoietin 1 corrects the lymphatic , but not the angiogenesis , defects , suggesting that Angiopoietin 2 acts as a Tie 2 agonist in the former setting , but as an antagonist in the latter setting . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
A new study in this issue of Developmental Cell shows that Angiopoietin 2 ( Ang 2 ) , a ligand for the endothelial Tie 2 receptor tyrosine kinase , has a dual function in the processes of postnatal angiogenesis and vascular remodeling . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 and angiopoietin 2 share the same binding domains in the Tie 2 receptor involving the first Ig like loop and the epidermal growth factor like repeats . ^^^ Angiopoietin 1 ( Ang 1 ) and angiopoietin 2 ( Ang 2 ) have been identified as ligands with different effector functions of the vascular assembly and maturation mediating receptor tyrosine kinase Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
RESULTS : In human epiretinal membranes surgically obtained from eyes with ischemic retinal disorders , substantial upregulation of angiopoietin 2 ( Ang 2 ) and the receptor Tie 2 was recorded than in those from eyes with nonischemic diseases , whereas expression of Ang 1 was constant in all membranes . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Expression of angiopoietin 2 gene and its receptor Tie 2 in hepatocellular carcinoma . ^^^ To explore the relationship of angiogenesis related angiopoietin 2 gene and its receptor Tie 2 with angiogenesis and the biology of hepatocellular carcinoma ( HCC ) , angiopoietin 2 gene , Tie 2 and CD 34 protein expression in 22 resected HCC , 8 cirrhotic and 8 control liver specimens were investigated by in situ hybridization and immunohistochemistry respectively , and the level of angiopoietin 2 and Tie 2 expression in HCC were compared in terms of tumor biological parameters . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Cyclical mechanical stretch enhances angiopoietin 2 and Tie 2 receptor expression in cultured human umbilical vein endothelial cells . ^^^ These increases in angiopoietin 2 and Tie 2 receptor proteins at 6 h were blocked by the addition ( 30 min before stretch ) of the protein kinase C inhibitor G6976 ( 16 nM ) or the tyrosine kinase inhibitor herbimycin A ( 24 microM ) . ^^^ Similar to protein expression , the levels of angiopoietin 2 and Tie 2 receptor mRNAs in HUVECs increased 3 . 1 fold and 2 . 5 fold respectively after stretch for 6 h . ^^^ Cyclical mechanical stretch increased ( and G6976 or herbimycin A abrogated these increases ) the immunohistochemical labelling of angiopoietin 2 and Tie 2 receptor after a 6 h stretch . ^^^ Thus cyclical mechanical stretch activates the expression of angiopoietin 2 and the Tie 2 receptor , but not angiopoietin 1 or the Tie 1 receptor , in cultured HUVECs . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 2 ( Ang 2 ) appears to be a naturally occurring antagonist of the endothelial receptor tyrosine kinase Tie 2 , an important regulator of vascular stability . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Increased expression of angiopoietin 2 and Tie 2 receptor in a rat model of myocardial ischaemia / reperfusion . ^^^ Angiopoietin 1 ( Ang 1 ) , angiopoietin 2 ( Ang 2 ) , Tie 1 and Tie 2 were measured immediately after relief of occlusion , and 1 , 6 , 24 and 72 h after reperfusion , by Northern blot , Western blot and immunohistochemical staining . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The study of angiopoietin 1 ( Ang 1 ) and angiopoietin 2 ( Ang 2 ) , ligands of receptor tyrosine kinase 2 ( Tie 2 ) , showed that while stroma derived Ang 2 was increased , epidermal Ang 1 expression was completely abolished at early papilloma formation . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Colocalization of Tie 2 , angiopoietin 2 and vascular endothelial growth factor in fibrovascular membrane from patients with retinopathy of prematurity . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
These included familiar endothelial cell associated genes such as VEGF , VEGF receptor ( VEGFR ) 1 , VEGFR 2 , angiopoietin 2 , Tie 1 , Tie 2 , Edg 1 receptor , VE cadherin , claudin 5 , connexin 37 , CD 31 , and CD 34 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Recent studies have implicated the Tie 2 tyrosine kinase receptor and its main ligands angiopoietin 1 ( Ang 1 ) and angiopoietin 2 ( Ang 2 ) as crucial regulators of mural cell recruitment during angiogenesis . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Implantation in marmosets occurs at day 11 of pregnancy ; hence , these time points were chosen so that the peri implantation period and very early pregnancy could be studied . mRNAs for VEGF , VEGFR 1 and VEGFR 2 , angiopoietin 1 , angiopoietin 2 and their receptor Tie 2 were localized and quantified by in situ hybridization . ^^^ These data provide comprehensive evidence that VEGFR 1 and 2 , and angiopoietin 1 , angiopoietin 2 and Tie 2 interactions may be involved in the preparation of endometrium for implantation , remodelling of the maternal vasculature and trophoblast invasion during the peri implantation period in this primate species . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 ( Ang 1 ) and angiopoietin 2 ( Ang 2 ) belong to a novel family of endothelial growth factors that function as ligands for the endothelial specific receptor tyrosine kinase , Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 2 and Tie 2 , but not angiopoietin 1 mRNA were increased with ROP , and angiopoietin 2 was reduced with PD 123319 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Plasma angiopoietin 1 , angiopoietin 2 and Tie 2 in breast and prostate cancer : a comparison with VEGF and Flt 1 . ^^^ These growth factors include angiopoietin 1 ( Ang 1 ) , angiopoietin 2 ( Ang 2 ) and vascular endothelial growth factor ( VEGF ) , which act through receptors Flt 1 and Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Both angiopoietin 1 ( Ang 1 ) and angiopoietin 2 ( Ang 2 ) are ligands for the endothelial cell specific receptor tyrosine kinase Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
PURPOSE : Angiopoietin 1 ( Ang 1 ) and angiopoietin 2 ( Ang 2 ) are major ligands for the endothelium specific tyrosine kinase receptor Tie 2 and are important regulators of endothelial cell survival . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Aim : Angiopoietin 1 ( Ang 1 ) and its antagonist , angiopoietin 2 ( Ang 2 ) , are novel ligands that regulate the Tie 2 receptor . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
We examined the vascular maturation regulators , angiopoietin 1 , angiopoietin 2 , and tie 2 receptor , under different weight modifying conditions . ^^^ Adipocytes expressed angiopoietin 1 , while adipose endothelial cells expressed angiopoietin 2 and tie 2 . ^^^ Angiopoietin 2 and tie 2 mRNA levels were stable . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Gene expression of vascular endothelial growth factor ( VEGF ) and receptor VEGF R 2 , as well as Tie 2 and its ligands angiopoietin 1 ( Ang 1 ) and angiopoietin 2 ( Ang 2 ) were assessed by reverse transcription PCR . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Tie 2 is an endothelial cell specific receptor tyrosine kinase , whose activation is positively and negatively modulated by angiopoietin 1 and angiopoietin 2 , respectively . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Enhanced expression of angiopoietin 2 and the Tie 2 receptor but not angiopoietin 1 or the Tie 1 receptor in a rat model of myocardial infarction . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
One peptide , NLLMAAS , completely abolished the binding to Tie 2 of both angiopoietin 2 and angiopoietin 1 ( Ang 1 ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
OBJECTIVE : Angiopoietin 2 ( Ang 2 ) is a non signal transducing ligand of the endothelial receptor tyrosine kinase Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Plasma angiopoietin 1 , angiopoietin 2 , angiopoietin receptor tie 2 , and vascular endothelial growth factor levels in acute coronary syndromes . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Individual spheroid culture of EC or OB leads to significant alterations in gene expression compared to standard monolayer culture ( upregulation of Tie 2 in EC ; upregulation of angiopoietin 2 in osteoblasts ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
BACKGROUND : Angiopoietin 1 ( Ang 1 ) and angiopoietin 2 ( Ang 2 ) bind to the endothelial specific receptor tyrosine kinase , TIE 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
In addition , NVP LAQ 824 treatment inhibited the expression of angiogenesis related genes such as angiopoietin 2 , Tie 2 , and survivin in endothelial cells and down regulated hypoxia inducible factor 1 alpha and VEGF expression in tumor cells . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 , angiopoietin 2 and Tie 2 were detectable on those cells which expressed VEGFA , flt 4 and Tie 2 from weeks 5 to 12 of gestation . ^^^ The expression of angiopoietin 1 and angiopoietin 2 were weakly and Tie 2 was strongly . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
BACKGROUND : Derangements in the balance of the Tie 2 receptor ligands , angiopoietin 1 and angiopoietin 2 ( Ang 1 and Ang 2 ) , have been implicated in the growth and differentiation of several human tumors . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Immunohistochemical staining of uteri and pituitaries was performed under strictly controlled conditions for VEGF and its receptor VEGFR 2 , Angiopoietin 1 ( Ang 1 ) and angiopoietin 2 and their tyrosine kinase receptor Tie 2 , and platelet endothelial adhesion factor ( as an index of vascularity ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Gene array and LightCycler analyses show an up regulation of angiogenic factors such as VEGF , VEGF receptor 2 , angiopoietin 1 , angiopoietin 2 , tie 2 , angiogenin , and interleukin 8 but a down regulation of collagen XVIII / endostatin and Tie 1 in CEACAM 1 overexpressing microvascular endothelial cells . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
OBJECTIVE : Here we examine the effects of the angiogenic growth factors angiopoietin 1 and angiopoietin 2 on eosinophil function in vitro and possible involvement of the angiopoietin receptor Tie 2 . ^^^ The effect on eosinophil migration of angiopoietin 1 was reversed by an antibody against the Tie 2 receptor and by angiopoietin 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Plasma vascular endothelial growth factor , angiopoietin 2 , and soluble angiopoietin receptor tie 2 in diabetic retinopathy : effects of laser photocoagulation and angiotensin receptor blockade . ^^^ BACKGROUND : Proliferative diabetic retinopathy ( PDR ) may be a response to abnormal angiogenic growth factors such as vascular endothelial growth factor ( VEGF ) , angiopoietin 2 ( Ang 2 ) , and the soluble angiopoietin receptor tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 2 ( Ang 2 ) modulates Tie 2 receptor activation . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 2 ( Ang 2 ) is a complex regulator of vascular remodeling that plays a role in both blood vessel sprouting and blood vessel regression through its receptor Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
DESIGN AND METHODS : Renal expression of VEGF , angiopoietin 1 ( Ang 1 ) , angiopoietin 2 ( Ang 2 ) and their receptors , VEGF R 2 and Tie 2 , were assessed using reverse transcription polymerase chain reaction , immunohistochemistry and Western blotting , in control and streptozotocin diabetic rats , untreated or receiving the AT 1 receptor antagonist , valsartan , or the AT 2 receptor antagonist , PD 123319 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The Tie 2 ligand angiopoietin 2 destabilizes quiescent endothelium through an internal autocrine loop mechanism . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
We found that mouse C2C12 skeletal myocytes lack tie 2 , yet dose dependently adhered to angiopoietin 1 and angiopoietin 2 similarly to laminin , fibronectin , vitronectin , and more than to collagen 1 , 3 , and 4 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : We investigated the expression of VEGF A , VEGF C , angiopoietin 1 ( Ang 1 ) , angiopoietin 2 ( Ang 2 ) , and the receptor Tie 2 by quantitative polymerase chain reaction in a cohort of 90 patients younger than 61 years with de novo AML entered into the German AML Sddeutsche Hmoblastose Gruppe Hannover 95 trial . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Recently , a role for the angiopoietin signaling system in psoriasis has been suggested by studies that demonstrate an up regulation of the tyrosine kinase receptor Tie 2 ( also known as Tek ) as well as angiopoietin 1 and angiopoietin 2 in human psoriatic lesions . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The levels of VEGF A , VEGF R 1 , VEGF R 2 , neuropilin 1 , angiopoietin 1 , angiopoietin 2 , Tie 2 , and hypoxanthine phosphoribosyltransferase mRNAs were determined by real time reverse transcriptase polymerase chain reaction . ^^^ RESULTS : Vascular endothelial growth factor , angiopoietin 1 , and angiopoietin 2 appeared to be expressed to variable levels in most samples , whereas Tie 2 , VEGF R 1 , and VEGF R 2 were undetectable . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Structure of the angiopoietin 2 receptor binding domain and identification of surfaces involved in Tie 2 recognition . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
AIM : To determine plasma levels of angiopoietin 1 and angiopoietin 2 ( Ang 1 , Ang 2 ) , their soluble receptor Tie 2 , vascular endothelial growth factor ( VEGF ) , its soluble receptor Flt 1 ( as indices of angiogenesis ) , and von Willebrand factor ( vWf , marking endothelial damage / dysfunction ) in sickle cell disease ( SCD ) patients with proliferative sickle retinopathy ( PSR ) , with non proliferative retinopathy ( NPR ) , or no retinopathy ( NR ) and in control subjects with normal haemoglobin ( AA subjects ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
At the early stage ( day 6 ) , glomerular expression of VEGF and receptors flk 1 and flt 1 as well as Ang 1 , and receptor Tie 2 were increased , and glomerular monocyte infiltration and the expression of angiopoietin 2 ( Ang 2 ) , a natural antagonist of Ang 1 , were reduced . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
This study focused on effects of 2 other angiogenic growth factors , angiopoietin 1 and angiopoietin 2 , on human neutrophils and on the involvement of the angiopoietin receptor Tie 2 . ^^^ CONCLUSIONS : Data suggest that a Tie 2 receptor is expressed by human neutrophils whose active site ligation with either angiopoietin 1 or angiopoietin 2 exerts migratory effects on the one hand and arrests VEGF mediated chemotaxis on the other . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Vascular endothelial growth factor ( VEGF ) , angiopoietin 2 ( Ang 2 ) , and soluble Tie 2 ( sTie 2 ) were determined in the serum of 36 CHC patients , before and after receiving antiviral combination therapy with pegylated interferon alpha 2b plus ribavirin , and in 15 healthy controls . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
ECM genes profiled included the angiopoietin 1 and related genes ( angiopoietin 2 , tyrosine kinase with immunoglobulin like and EGF like domains 1 ( TIE 1 ) and 2 ( TIE 2 ) , vascular endothelial growth factor ( VEGF ) and related receptors ( VEGF receptor 1 , VEGF receptor 2 and neuropilin 1 ) , thrombospondin 4 , alpha 2 macroglobulin and transforming growth factor beta 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Both angiopoietin 1 ( Ang 1 ) and angiopoietin 2 ( Ang 2 ) bind the receptor tyrosine kinase Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Placental expression of angiopoietin 1 , angiopoietin 2 and tie 2 during placental development in an ovine model of placental insufficiency fetal growth restriction . ^^^ Angiopoietin 1 ( Ang 1 ) and Angiopoietin 2 ( Ang 2 ) are angiogenic growth factors expressed in the placenta , and compete for binding to a common receptor , Tunica interna endothelial cell kinase 2 ( Tie 2 ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Serum levels of vascular endothelial growth factor ( VEGF ) , soluble Flt 1 and Flk 1 receptors , placental growth factor ( PlGF ) , angiopoietin 2 ( Ang 2 ) and soluble Tie 2 receptor were determined by ELISA . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Potential role of soluble angiopoietin 2 and Tie 2 in patients with inflammatory bowel disease . ^^^ The aim of the study was to evaluate the serum markers of angiogenesis angiopoietin 2 ( Ang 2 ) and soluble angiopoietin receptor Tie 2 in patients with ulcerative colitis ( UC ) and Crohn ' s disease ( CD ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 2 ( Ang 2 ) is a Tie 2 ligand that destabilizes vascular structures , allowing for neovascularization or vessel regression depending on local vascular endothelial cell growth factor ( VEGF ) concentrations . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
OBJECTIVE : The purpose of this study was to investigate the differential expression of angiopoietin 1 , angiopoietin 2 , and Tie receptors ( Tie 1 and Tie 2 ) in placentas from pregnancies complicated by placenta accreta . ^^^ Enzyme linked immunosorbent assay in the placental lysates showed that women with placenta accreta demonstrated significantly higher angiopoietin 2 and lower Tie 2 concentrations than did women with normal pregnancies ( P = . 026 and . 003 , respectively ) . ^^^ CONCLUSION : These observations suggest that the participation of up regulated angiopoietin 2 and down regulated Tie 2 in the placental tissues may indicate a role for these angiogenic factors in the development of placenta accreta . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
To investigate the possible role of angiogenic mechanisms , we have studied the immunohistochemical expression of vascular endothelial growth factor ( VEGF ) , angiopoietin 1 ( Ang 1 ) , angiopoietin 2 ( Ang 2 ) and their receptors ( VEGFR 1 , VEGFR 2 , Tie 2 ) in ADPKD , Caroli ' s disease , normal and fetal livers . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
RTQ PCR demonstrated that VEGF , its receptors VEGFR 1 and VEGFR 2 , and angiopoietin 2 and its receptor ( Tie 2 ) were also overexpressed ( P < 0 . 05 ) in PTC . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 , angiopoietin 2 and Tie 2 expression in eutopic endometrium in advanced endometriosis . ^^^ Using quantitative competitive PCR ( QC PCR ) combined with the reverse transcription of total RNA into cDNA , we investigated the expression of angiopoietin 1 ( Ang 1 ) , angiopoietin 2 ( Ang 2 ) and Tie 2 in the eutopic endometrium from 56 women with severe endometriosis and that from 64 women without endometriosis during the follicular and luteal cycles . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Here , we demonstrate constitutive activation of the endothelial tie 2 receptor in human hemangioma of infancy and , using a murine model of hemangioma , bEnd . 3 cells ; we show that bEnd . 3 hemangiomas produce both angiopoietin 2 ( ang 2 ) and its receptor , tie 2 , in vivo . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
METHODS : Fresh surgically resected specimens of HCC and noncancerous liver ( NCL ) tissue from 38 patients with HCC were obtained , and expression of angiopoietin 1 ( Ang 1 ) , angiopoietin 2 ( Ang 2 ) , Tie 2 , and VEGF messenger RNA ( mRNA ) was examined by real time quantitative reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
BACKGROUND AND OBJECTIVES : Angiopoietin 1 ( Ang 1 ) and its natural antagonist angiopoietin 2 ( Ang 2 ) , both ligands for the receptor tyrosine kinase Tie 2 , are known to play an essential role in normal and pathological angiogenesis . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
CONCLUSIONS : Present findings that Ang 2 and VEGF are co upregulated and that Tie 2 is expressed in a variety of cell types in CNVMs further support a crucial role of the interaction between VEGF and Ang 2 in pathologic angiogenesis of CNVM formation . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 ( Ang 1 ) stimulates endothelial and vascular network differentiation through the Tie 2 receptor tyrosine kinase , while Ang 2 modulates this activation in embryo and tumor growth . ^^^ Because Tie 2 is widely expressed by differentiating renal endothelia , this study is consistent with the hypothesis that Ang 2 has roles in kidney vascular maturation . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Ang 2 counteracts this effect by competitively inhibiting the binding of Ang 1 to Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The angiopoietins ( Ang 1 and Ang 2 ) and Tie 2 ligand receptor system is essential for the regulation of vascular maturation and stability during embryonic development . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The Tie 2 receptor has been implicated in stabilization and maturation of vessels through action of an agonist ligand , angiopoietin 1 ( Ang 1 ) and an antagonistic ligand , Ang 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
This study is the first to localize Ang 2 and Tie 2 in human endometrium and to study Ang 2 regulation in cultured human endometrial endothelial cells ( HEECs ) . ^^^ Immunohistochemistry revealed that expression of Ang 2 and Tie 2 was absent from the glands , low in stromal cells , and intense in the endothelial cells . ^^^ The phase of the menstrual cycle did not appear to affect the expression of Ang 2 or Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The survival effect of high concentration Ang 2 was blocked by pre treatment with soluble Tie 2 receptor and the PI 3 ' kinase specific inhibitors , wortmannin and LY 294002 . ^^^ Accordingly , 800 ng / ml of Ang 2 induced phosphorylation of Tie 2 , the p 85 subunit of phosphatidylinositol 3 ' kinase ( PI 3 ' kinase ) , and serine threonine kinase Akt at Ser 473 in the human umbilical vein endothelial cells ; lower concentrations of Ang 2 ( 50 400 ng / ml ) did not produce notable effects . ^^^ These findings indicate that at high concentrations , Ang 2 , like Ang 1 , can be an apoptosis survival factor for endothelial cells through the activation of the Tie 2 receptor , PI 3 ' kinase and Akt , and thus may be a positive regulator of tumor angiogenesis . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The angiogenesis / vasculogenesis pathway is required for embryonic survival and includes several receptors ( VEGFR 1 , VEGFR 2 , Tie 2 ) and ligands ( VEGF , Ang 1 , Ang 2 , neuropillin ) . ^^^ Ang 1 and Tie 2 decreased in trophoblastic giant cells and Ang 2 was decreased in placental endothelial cells . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The aim of this study was to investigate the localization of Ang 1 , Ang 2 , their common receptor Tie 2 , and VEGF messenger ribonucleic acid ( mRNA ) at the different stages of the functional luteal phase and after rescue by hCG . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Although Ang 2 and HB EGF induce angiogenesis , their link to the angiopoietin ( Ang ) Tie 2 system remains undefined . ^^^ We tested the effects of Ang 2 on Ang 1 , Ang 2 , or Tie 2 expression in cardiac microvascular endothelial cells expressing the Ang 2 receptors AT ( 1 ) and AT ( 2 ) . ^^^ Ang 2 significantly induced Ang 2 mRNA accumulations without affecting Ang 1 or Tie 2 expression , which was inhibited by protein kinase C inhibitors and by intracellular Ca ( 2+ ) chelating agents . ^^^ Although neither Ang 2 nor Ang 1 alone induced angiogenesis , soluble Tie 2 Fc that binds to angiopoietins attenuated AT ( 1 ) mediated angiogenesis . ^^^ These findings suggested that ( 1 ) Ang 2 induces Ang 2 and VEGF expression without affecting Ang 1 or Tie 2 and ( 2 ) AT ( 1 ) stimulates processing of pro HB EGF by metalloproteinases , and the released HB EGF transactivates EGFR to induce angiogenesis via the combined effect of Ang 2 and VEGF , whereas AT ( 2 ) attenuates them by blocking EGFR phosphorylation . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
RESULTS : Immunohistochemical analyses indicated that Ang 1 is selectively expressed in vascular muscular cells , whereas angiopoietin 2 ( Ang 2 ) and Tie 2 are selectively expressed in endothelial cells . ^^^ Accordingly , Ang 1 mRNA is mainly expressed in cultured porcine coronary artery vascular smooth muscle cells , whereas Ang 2 and Tie 2 mRNAs are mainly expressed in cultured porcine coronary artery endothelial cells ( PCAECs ) . ^^^ Ang 1 ( 200 ng / ml ) induced Tie 2 phosphorylation , while Ang 2 ( 200 ng / ml ) did not produce Tie 2 phosphorylation . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Here we report that in addition to vascular endothelial growth factor A ( VEGF A ) , human endometrium expresses messenger ribonucleic acids ( mRNAs ) encoding VEGF C , placenta growth factor ( PlGF ) , the angiopoietins , angiopoietin 1 ( Ang 1 ) and Ang 2 , and the receptors VEGFR 3 ( Flt 4 ) , Tie 1 , and Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Using probes specific for two recently described ligands for tie 2 , Ang 1 and Ang 2 , we have shown that mRNA encoding Ang 1 is upregulated when 3T3 L 1 fibroblasts are differentiated to adipocytes . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
By contrast , ang 2 was transcribed around arteries in which the endothelium down regulated tie 2 mRNA . ^^^ The aorta and large arteries of the heart outflow tract were never surrounded by ang 2 positive cells and maintained tie 2 expression . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Serial sections of 32 human glioma tissues ( 14 glioblastomas , eight anaplastic astrocytomas , seven astrocytomas , and three pilocytic astrocytomas ) were immunostained against Ang 2 , vascular endothelial growth factor , Tie 2 , von Willebrand factor , and alpha smooth muscle actin . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
In this study , by using reverse transcription polymerase chain reaction and Northern and Western blotting , we demonstrated that Ang 1 , Ang 2 , and Tie 2 were expressed during early metanephrogenesis when interstitial and glomerular capillaries begin to form . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Ang 2 supplemented gels appeared to prompt earlier angiogenic induction , whereas sequestration of Ang 2 with soluble Tie 2 receptor appeared to delay angiogenic induction . ^^^ Soluble Tie 2 treatment did not significantly decrease cumulative microvessel length , and no significant increase in neovessel length was seen with Ang 2 supplemented gels . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
METHOD : By means of immunostaining we studied vascular endothelial growth factor ( VEGF ) , Tie 1 , Tie 2 , Ang 1 , Ang 2 in endothelial cells ( EC ) of CAVM ( 30 specimens ) and control cortical vessel ( 7 specimens ) in the temporal lobe . ^^^ CONCLUSION : Up regulated VEGF in part of brain and Tie 2 , Ang 2 high expression in EC of some vessels may be one of major factors for CAVM formation growth , and rupture in the embryonic period . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Ang 2 is known to inhibit Ang 1 mediated phosphorylation of Tie 2 as well as cellular responses during embryonic development . ^^^ Tie 2 was tyrosine phoshorylated by Ang 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Ang 1 , Ang 2 , Tie 2 , and VEGF expression in normal human renal cortex was examined with immunofluorescence and immunohistochemical analyses . ^^^ RNA and protein extracted from human glomeruli , cultured human podocytes , and cultured human endothelial cells were analyzed for Ang 1 , Ang 2 , and Tie 2 by using reverse transcription PCR and Western blotting . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
OBJECTIVE : Angiopoietin 1 ( Ang 1 ) and Ang 2 are ligands for the receptor tyrosine kinase , Tie 2 . ^^^ Ang 1 , a Tie 2 agonist , may have a vascular stabilizing role in angiogenesis , while Ang 2 , an endogenous antagonist of Tie 2 , may have an early role in angiogenesis , destabilizing existing vasculature . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
In this study , we examined the relationship between AML cells and endothelial cells by analyzing the expression profile of angiogenic factors , angiopoietin 1 ( Ang 1 ) , Ang 2 , Tie 2 ( a receptor for angiopoietins ) and vascular endothelial growth factor ( VEGF ) . ^^^ As for CD 7 ( + ) AML cells , despite the frequent and intense expression of endothelial cell associated molecules ( such as Ang 2 , CD11c and CD 18 ) , intensity of Tie 2 expression was quite low ( P < 0 . 05 ) . ^^^ Although Ang 2 is recognized as a natural antagonist for Tie 2 , our data presented here suggested the alternative role of Ang 2 in the relationship between endothelial cells and leukemia cells , at least in a subset of leukemia such as CD 7 ( + ) AML . ^^^ These results were supported by the study using AML cell lines , KG 1 ( CD 7 negative ) and its subline KG 1a ( CD 7 positive ) ; KG 1 had mRNA expression profile of Ang 1 ( + ) Ang 2 ( ) Tie 2 ( + ) , while KG 1a showed Ang 1 ( + ) Ang 2 ( + ) Tie 2 ( ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
In this study , we evaluated whether estrogen modulates the activity and expression of Tie 2 receptors , Ang 1 and its endogenous antagonist ; angiopoietins 2 ( Ang 2 ) in non reproductive organs . ^^^ Our results suggest that the effects of estrogen on the vasculature of non reproductive organs require the inhibition of angiopoietin 1 Tie 2 receptor pathway and that this inhibition is achieved through simultaneous down regulation of Ang 1 and Tie 2 expression and elevation in Ang 2 expression . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Specifically , 1 ) VEGF / Flt and Ang 1 / Tie 2 may promote trophoblast growth , 2 ) VEGF / KDR and Ang 1 / Tie 2 may support fetoplacental vascular development and stabilization , 3 ) sFlt may balance VEGF actions , and 4 ) Ang 2 / Tie 2 may remodel the maternal vasculature . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The distinct roles of angiopoietin ( Ang ) 1 and Ang 2 , counteracting ligands for the endothelium specific Tie 2 receptor , in tumor development and progression have remained poorly understood . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Immunohistochemical analysis was used to determine the expression of Ang 1 , Ang 2 , Tie 1 and Tie 2 in synovial tissue of normal subjects and those with RA and OA . ^^^ Ang 1 , Ang 2 , Tie 1 and Tie 2 mRNA and protein expression were quantified in synovial tissues and RA synovial tissue fibroblasts with real time reverse transcription polymerase chain reaction and western blot analysis . ^^^ Generally Ang 1 , Ang 2 , Tie 1 and Tie 2 mRNA levels were higher in RA synovial tissue compared to normal and OA synovial tissues , and RA synovial tissue fibroblasts . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
It has been proposed that angiopoietins 1 ( Ang 1 ) and 2 ( Ang 2 ) are pro and anti angiogenic owing to their respective agonist and antagonist signaling action through the Tie 2 receptor . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
At different stages of tumor growth , the histological aspects were described and sections were immunostained for VEGF , Ang 2 and their receptors VEGFR 1 , VEGFR 2 and Tie 2 . ^^^ RESULTS : Ang 2 and Tie 2 were detected in the endothelial cells of vessels surrounded by tumor cells , occuring early in our study , with immunostaining taking place from day 4 to day 24 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
To determine the significance and regulation of the angiopoietin ( Ang ) pathway in highly vascular human renal cell carcinomas ( RCCs ) , this study has investigated the expression of the Ang 1 , Ang 2 , Ang 4 , and Tie 2 genes in a series of normal ( n = 26 ) and neoplastic ( n = 45 ; clear cell n = 35 , papillary n = 10 ) human kidney tissues , examined the pattern of Ang 2 and Tie 2 protein expression , and correlated expression with clinicopathological variables . ^^^ Ang 1 , Ang 2 and Tie 2 , but not Ang 4 mRNA , were detected in normal and tumour samples . ^^^ A significant increase in Ang 2 ( p < 0 . 001 ) and a decrease in Tie 2 receptor mRNA ( p = 0 . 001 ) were observed , but no significant difference was observed in Ang 1 mRNA abundance between normal kidney and RCC ( p = 0 . 37 ) . ^^^ Immunohistochemistry for Ang 2 showed strong expression in vascular endothelium and weak expression in tumour cells , whereas Tie 2 was expressed exclusively on endothelium . ^^^ Tie 2 gene expression was positively correlated with Ang 2 expression in cancers ( p = 0 . 001 ) and showed a borderline significant association with Ang 1 ( p = 0 . 06 ) , but there was no significant relationship between Ang 1 and Ang 2 ( p = 0 . 69 ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
However , there was a significant increase in expression of ANG 2 and its receptor Tie 2 in menorrhagic tissues , which may be important in destabilizing the endometrial vasculature . ^^^ CONCLUSION ( S ) : Differences in the expression of ANG 2 , Tie 2 , Tie 1 , and eNOS were found in menorrhagic endometrium , which may represent a new target for therapeutic intervention to correct menorrhagic conditions . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : We have measured the expression of angiogenesis regulating genes angiopoietin 1 ( Ang 1 ) , angiopoietin 1 ( Ang 2 ) and their receptor Tie 2 , vascular endothelial growth factor ( VEGF ) and its receptors VEGFR 1 and VEGFR 2 in sorted population of CD34+ and CD34+ / CD133+ cells from human cord blood and bone marrow , and in their differentiating progeny , using real time reverse transcriptase polymerase chain reaction . ^^^ RESULTS : A higher expression of Ang 1 , Ang 2 , and Tie 2 mRNAs was detected in CD34+ / CD133+ cord blood cells as compared with CD 34 / CD133 fraction , but no expression of these genes was detected in burst forming unit erythroid ( BFU E ) nor colony forming unit granulocyte macrophage ( CFU GM ) colonies . ^^^ The level of Ang 1 and Tie 2 mRNAs , but not that of Ang 2 mRNA gradually decreased during a 14 d incubation of cord blood CD34+ cells in a liquid culture . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Tie 2 messenger RNA , the receptor of Ang 1 and Ang 2 , was detected at the same level in FNH as in normal liver . ^^^ CONCLUSIONS : A specific increase of Ang 1 / Ang 2 ratio in FNH , in the presence of the functional Tie 2 receptor , might be involved in the formation of hyperplastic and dystrophic vessels of FNH . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Here , we studied the roles of Ang 1 , its natural antagonist Ang 2 , and their receptor Tie 2 in rat cardiac allograft arteriosclerosis . ^^^ Ang 2 and Tie 2 immunoreactivity was induced mainly in capillaries and postcapillary venules in chronic allografts when compared with syngeneic controls , but no immunoreactivity was found in arterial endothelium . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
To test this hypothesis we measured capillary density , and the expressions of VEGF , Ang 1 , Ang 2 , and the Tie 2 receptor and its phosphorylation state during repetitive episodes of myocardial ischemia in chronically instrumented canines . ^^^ The change in capillary density paralleled with VEGF and Ang 2 expression but was inversely related to Tie 2 phosphorylation . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
However , using bovine aortic endothelial cells ( BAEC ) , we found that only Ang 2 expression , but neither Ang 1 nor Tie 2 , responded to these two angiogenic stimuli , which was consistent with many previous reports . ^^^ In conclusion , our data suggest that both hypoxia and VEGF treatment differentially regulate the angiopoietin / Tie2 system in the two vascular cells and that , particularly in BRP , the regulation of Ang 1 , but not Ang 2 , and Tie 2 expression may play an important role in vascular development . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
In this study , we investigated the expression of Ang 1 , Ang 2 , Tie 2 , and vascular endothelial growth factor ( VEGF ) in surgically resected specimens from 46 patients with HCC to determine their potential role in tumor angiogenesis and its progression . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Using reverse transcription polymerase chain reaction and immunohistochemistry , we demonstrate that testicular vascular endothelial growth factor A ( VEGF A ) , ang 1 , ang 2 , and the ang receptor tie 2 are expressed in the testis and that hormonal stimulation with hCG is accompanied by increased expression of VEGF A and ang 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Two of the Angs , Ang 1 and Ang 4 , activate the Tie 2 receptor , whereas Ang 2 and Ang 3 inhibit Ang 1 induced Tie 2 phosphorylation . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Using a combination of immunohistochemistry , laser capture microdissection and real time quantitative reverse transcription PCR , we showed that tumor derived VEGF significantly up regulated the expression of Ang 2 in host stroma endothelial cells , resulting in markedly increased Ang 2 / Tie 2 mRNA copy number ratio in vivo . ^^^ In addition , a significant correlation was observed between VEGF and Ang 2 mRNA expression ( P < 0 . 01 ) but not between VEGF and Ang 1 or Tie 2 in human ovarian cancer specimens . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The present study shows the expression of Tie 2 receptors , Ang 1 , and its endogenous antagonist , Ang 2 in mouse adrenal in vivo . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
METHODS AND RESULTS : The myocardial expression of VE cadherin / beta catenin , Ang 1 , Ang 2 , and their receptor Tie 2 was examined in DCM , ischemic cardiomyopathy ( ICM ) , and in control subjects through the use of real time RT PCR , Western blotting , and immunocytochemistry . ^^^ Although Ang 1 was not changed , Ang 2 expression was downregulated and Tie 2 protein expression was upregulated both in DCM and ICM ( P < 0 . 05 ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The expression of Ang 1 , Ang 2 , VEGF , and Tie 2 , a member of the receptor tyrosine kinases and the natural receptor for both Ang 1 and Ang 2 , follows a distinct transcriptional profile in vivo . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
STUDY DESIGN : We measured mRNA expression of vascular endothelial growth factor ( VEGF ) , angiopoietin 1 and 2 ( Ang 1 and Ang 2 ) , their receptors VEGFR 1 , VEGFR 2 , Tie 2 , fibroblast growth factor 2 ( FGF 2 ) , and its receptor FGF 2R in placental tissue of diabetes type 1 patients , in normal term placenta , and endometrium of non pregnant women by real time reverse transcriptase PCR . ^^^ We did not detect a significant difference in the expression of Ang 1 , Ang 2 , Tie 2 , VEGF , VEGFR 1 , VEGFR 2 , FGF 2 , and FGF 2R in normal and diabetes type 1 placenta . ^^^ The expression of Ang 1 , Ang 2 , Tie 2 , VEGF , VEGFR 1 , VEGFR 2 , FGF 2 , and FGF 2R was not different in normal and type 1 diabetes placenta . . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Expression of mRNA transcripts for the VEGF splice variants VEGF ( 121 ) , VEGF ( 189 ) , and VEGF ( 165 ) ; the receptors VEGF R 1 and VEGF R 2 ; the angiopoietins Ang 1 and Ang 2 ; and their receptor , Tie 2 , were measured in biopsy samples with multiplex polymerase chain reaction . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Western blot analysis suggested that expression of Ang 1 , Ang 2 , Tie 2 , and VEGF may be regulated at a transcriptional level . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Granulosa cells and thecal tissues in small ( < 4 mm ) , medium ( 4 5 mm ) or large ( > 5 mm ) individual follicles were collected for detection of mRNA expression of HGF , Ang 1 and Ang 2 in granulosa cells , and HGF receptor ( HGF R ) and Tie 2 in the theca cells by semi quantitative RT PCR . ^^^ The ratio of Ang 2 / Ang 1 increased in small , medium and large follicles from ovaries after eCG treatment , but Tie 2 mRNA expression in the theca cells did not change . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The present study used immunohistochemistry and in situ hybridization to examine whether angiopoietin 1 and 2 ( Ang 1 and Ang 2 ) , ligands for Tie 2 , are also expressed in the RA synovium . ^^^ Ang 1 and Ang 2 were expressed in all of 15 RA synovial samples , and their distribution pattern was similar to that of Tie 2 . ^^^ Double immunohistochemistry revealed coexpression of Ang 1 , Ang 2 , and Tie 2 in synovial components exhibiting proliferating cell nuclear antigen immunoreactivity . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The angiopoietin ( Ang ) family of growth factors includes Ang 1 , Ang 2 , Ang 3 , and Ang 4 , all of which bind to the endothelial receptor tyrosine kinase Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietins ( Ang 1 , Ang 2 , and Ang 3 ) are the ligands of Tie 2 receptor tyrosine kinase . ^^^ The essential roles of Ang 1 and Tie 2 in embryonic angiogenesis have been established , and studies have demonstrated the involvement of Ang 1 and Ang 2 in tumor angiogenesis . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
METHODS : In situ hybridization , reverse transcriptase polymerase chain reaction ( RT PCR ) and western blot analyses were performed to determine the mRNA and protein content for Ang 1 and Ang 2 and the Tie 2 receptor in the retinas of STZ diabetic and age matched control rats . ^^^ RESULTS : Using in situ hybridization analysis , Ang 1 , Ang 2 , and Tie 2 mRNA expression was observed in the ganglion cell layer ( GCL ) and the inner nuclear layer ( INL ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
To study a potential feedback system in the angiopoietin ( Ang ) Tie 2 system , the authors examined effects of Ang 1 and Ang 2 on Tie 2 expression on human umbilical vein endothelial cells ( HUVECs ) with or without stimulation by a potent inflammatory cytokine , tumor necrosis factor alpha ( TNF alpha ) . ^^^ Ang 1 , but not Ang 2 , down regulated Tie 2 expression on HUVECs without TNF alpha stimulation . ^^^ Both Ang 1 and Ang 2 attenuated TNF alpha induced Tie 2 up regulation . ^^^ Regulation of Tie 2 expression by Ang 1 or Ang 2 was not dependent on phosphatidylinositol 3 kinase . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietins ( Ang 1 and Ang 2 ) modulate the activity of the endothelial cell ( EC ) specific receptor tyrosine kinase Tie 2 , which together with vascular endothelial growth factor ( VEGF A ) and its EC specific receptors , VEGFR 1 and VEGFR 2 , regulate normal physiological vessel development . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 ( Ang 1 ) and 2 ( Ang 2 ) are endothelial growth factors that bind to the tyrosine kinase receptor Tie 2 and contribute to orchestrate blood vessel formation during angiogenesis . ^^^ In contrast , Ang 2 is classically considered as a Tie 2 antagonist , counteracting the stabilizing action of Ang 1 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
To investigate the functional consequences of blocking Ang 2 activity , we generated antibodies and peptide Fc fusion proteins that potently and selectively neutralize the interaction between Ang 2 and its receptor , Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : Real time quantitative reverse transcriptase PCR was used to measure levels of mRNA of tumor angiogenesis and lymphangiogenesis related factors [ vascular endothelial growth factor ( VEGF ) A , VEGF C , VEGF D , Flt 1 , KDR , Flt 4 , Ang 1 , Ang 2 , Tie 1 , Tie 2 , cyclooxygenase 2 , fibroblast growth factor 2 ( FGF 2 ) , Egr 1 , Prox 1 , and LYVE 1 ] in tumor specimens of 16 inflammatory breast cancer and 20 noninflammatory breast cancer patients . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The angiopoietins , Ang 1 and Ang 2 , and their common receptor , Tie 2 or Tek , constitute another signaling system that regulates angiogenesis , and which interacts with VEGF . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Messenger RNA expression of von Willebrand factor ( vWF ) ; smooth muscle alpha actin ( SMA+ ) ; platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) ; vascular endothelium cadherin ( VE Cad ) ; endothelial nitric oxide synthase ( eNOS ) ; vascular cell adhesion molecule 1 ( VCAM 1 ) ; tumor necrosis factor alpha ( TNF alpha ) ; matrix metalloproteinase ( MMP 9 , MMP 12 , and MMP 14 ) , and tissue inhibitors of MMPs ( TIMPs : TIMP 1 , TIMP 2 , TIMP 3 , TIMP 4 ) ; angiopoietins ( Ang 1 , Ang 2 ) ; and receptors Tie 1 and Tie 2 , were analyzed with reverse transcriptase polymerase chain reaction 2 , 6 , and 15 days after surgery . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Brain angiopoietin 1 ( Ang 1 ) , Ang 2 , Tie 1 , Tie 2 , vascular endothelial growth factor ( VEGF ) , VEGF R 1 , and VEGF R 2 mRNA levels were determined by RNAse protection assays , and CD 31 positive vessels were counted . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
In addition , improper creation of a new cysteine in Ang 2 ( Ang2S263C ) dramatically induced Ang 2 aggregation without activating Tie 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
In contrast , the role of Ang 2 remains less clear because it has been shown to behave as a Tie 2 agonist or antagonist under different experimental conditions . ^^^ The effect of Ang 2 is blocked by the coadministration with a soluble form of the Tie 2 receptor or Ang 1 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The mRNA species analyzed include VEGF and its receptors , VEGFR 1 and VEGFR 2 , and ANG 1 , ANG 2 and their receptor , Tie 2 . ^^^ In membrane samples , mRNA encoding for VEGF and its receptors was only inconsistently detected while the mRNA species encoding for ANG 1 , ANG 2 , and Tie 2 were found throughout all samples . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Constitutive expression of Ang 1 , Ang 2 , and their receptor Tie 2 was detected at both the mRNA and protein level in all the pituitary glands studied . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
These changes were associated with increased expressions of ANG 2 and its type 1 ( AT 1 ) and type 2 ( AT 2 ) receptors , endothelin 1 ( ET 1 ) and its type B receptor ( ETB ) , and angiopoietin 1 , together with decreased expressions of bone morphogeneic protein receptor 1A and 2 ( BMPR 1A and BMPR 2 , respectively ) and unchanged expression of the receptor tyrosine kinase with immunoglobulin and EGF homology domains 2 ( Tie 2 ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Striated muscle expressions ( Western blots ) of ANG 2 AT ( 1 ) receptor subtype , endothelial nitric oxide synthase , angiopoietin 1 and 2 , Tie 2 receptor , vascular endothelial growth factor and receptor , and platelet derived growth factor C at E 21 and P 7 were unaltered by antenatal diet exposure . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Although Ang 2 at high concentration weakly activated Tie 2 and p 70 S6K , it failed to activate Ras and MAPK , or to induce cell proliferation . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
OBJECTIVE : To study angiogenesis and blood vessel stabilization in the human corpus luteum , changes in expression of angiopoietin ( Ang ) 1 , Ang 2 , and their specific receptor , Tie 2 , together with the number of blood vessels and pericytes were examined in the corpus luteum throughout the menstrual cycle and in early pregnancy . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Ang 2 stimulated EPC migration was inhibited by soluble Tie 2 ectodomain . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
RESULTS : Hypertensive patients had higher levels of plasma VEGF , Ang 1 , Ang 2 , Tie 2 and platelet VEGF ( all P < or=0 . 01 ) , but not platelet Ang 1 , when compared with normotensive controls . ^^^ Amongst the hypertensives , plasma levels of VEGF correlated significantly with Ang 1 , Ang 2 , Tie 2 and platelet VEGF , whilst platelet VEGF correlated strongly with plasma levels of VEGF and Ang 1 ( all P < 0 . 05 ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
METHODS : The levels of serum Ang 2 and Tie 2 , a receptor for Ang 1 expressed on endothelial cells , were determined by enzyme linked immunosorbent assay . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
In addition , Ang 2 as well as its receptor Tie 2 expressions were higher in 12 pairs of gastric cancer tissue samples than those in corresponding adjacent samples by Western blot , while Ang 1 expression showed great heterogeneity . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
This study tests the hypothesis that abnormalities in plasma indices of angiogenesis , such as Vascular Endothelial Growth Factor ( VEGF ) and angiopoietins ( Ang 1 , Ang 2 ) , as well as their soluble receptors Flt 1 ( sFlt 1 ) and Tie 2 ( sTie 2 ) respectively , are present in women with in pregnancy induced hypertension ( PIH ) . ^^^ Results show that levels of plasma VEGF , Ang 1 , Ang 2 , sFlt 1 and Tie 2 were significantly different between the study groups . ^^^ Ang 2 , sFlt 1 and Tie 2 were undetectable in the platelet lysate in any of the patient groups or controls . ^^^ Abnormal indices of angiogenesis are evident in PIH and preeclampsia , with higher levels of sFlt 1 and lower levels of VEGF ; in PIH , increased levels of Ang 1 and Tie 2 , but reduced Ang 2 , are evident compared to normal pregnancy . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : Angs and Tie 2 mRNA levels were determined by real time quantitative RT PCR , Ang 2 and Tie 2 were localized by immunostaining , and ACTH regulation of Angs was investigated by real time quantitative RT PCR , Western blot , and ELISA . ^^^ Ang 2 was localized predominantly in the HFA periphery , whereas Tie 2 demonstrated endothelial localization . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
METHODS : We investigated the expression of angiopoietin ( Ang ) 1 , Ang 2 , Tie 2 , and vascular endothelial growth factor ( VEGF ) in regenerating liver tissue by quantitative reverse transcription polymerase chain reaction ( RT PCR ) using a LightCycler ( Roche Diagnostics ) and also immunohistochemical staining after 70 % hepatectomy in rats . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The angiopoietins Ang 1 and Ang 2 have been identified as ligands of the receptor tyrosine kinase Tie 2 ( refs . 1 , 2 ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 ( Ang 1 ) and 2 ( Ang 2 ) and their common receptor , Tie 2 , are thought to be critical regulators of tumor angiogenesis . ^^^ We examined expression of Ang 1 , Ang 2 , and their common receptor Tie 2 mRNAs and proteins in gastric cancers using in situ hybridization and immunohistochemistry . ^^^ The expression of Ang 1 , Ang 2 , and Tie 2 mRNA in cancer cells significantly correlated with the MVD ( p < 0 . 001 , < 0 . 001 and =0 . 019 , respectively ) . ^^^ Ang 1 and Tie 2 positivity correlated with advanced gastric cancers ( p < 0 . 05 ) and larger cancers had higher positive rates of Ang 1 , Ang 2 , and Tie 2 mRNA expression ( p < 0 . 001 , =0 . 010 and =0 . 039 , respectively ) . ^^^ Significant positive correlations were also found between mRNA expression of Tie 2 and those of Ang 1 and Ang 2 ( p < 0 . 01 and < 0 . 001 , respectively ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Angiopoietin 1 , 2 and Tie 2 expressions in endometrial adenocarcinoma the Ang 2 dominant balance up regulates tumor angiogenesis in the presence of VEGF . ^^^ We investigated Ang 1 , Ang 2 and Tie 2 expressions including balance and intratumoral vessels in the role of angiogenesis of endometrial adenocarcinoma . ^^^ The levels of Ang 1 , Ang 2 and Tie 2 expressions were expressed as staining score . ^^^ Ang 1 , Ang 2 , Tie 2 and CD 34 were expressed in the cytoplasm of tumor cells . ^^^ A significant correlation was found among Ang 1 , Ang 2 and Tie 2 expressions . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Interestingly , Ang 2 , an antagonist ligand of Tie 2 , inhibited Ang 1 induced HGF production and Ang 1 induced SMC migration . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Ang 1 , Ang 2 , Tie 2 , and TNF alpha messenger RNA expression were quantified by real time polymerase chain reaction . ^^^ Protein expression of vascular endothelial growth factor , Ang 2 , Tie 2 , TNF alpha , and the inflammatory infiltrate was determined using immunohistology . ^^^ Infliximab produced a significant reduction in protein expression of Ang 2 , vascular endothelial growth factor , and Tie 2 ( P < . 001 ) along with a decrease in messenger RNA expression of Ang 1 ( P < . 045 ) and Tie 2 ( P < . 021 ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Ang 2 at 150 and 300 ng / ml elicited a transient ( reaching peak values within 15 min of exposure ) increase in the phosphorylation of Tie 2 receptors , protein kinase B ( Akt ) , ERK1 / 2 , and p 38 members of the mitogen activated protein kinases . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
We induced a myocardial infarction ( MI ) in 12 mo old rats to analyze 1 ) protein expression in VEGF / Flt 1 / Flk 1 and angiopoietin ( Ang ) 1 / Ang 2 / Tie 2 systems , 2 ) the arteriolar DNA synthesis , 3 ) the extent of the arteriolar bed , and 4 ) the alteration in minimal coronary vascular resistance . ^^^ Arteriolar DNA synthesis was mainly associated with upregulation of Ang 2 and Tie 2 in both LV regions . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Here we present the crystal structures of the Tie 2 ligand binding region alone and in complex with Ang 2 . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
The increase of flk 1 and flt 1 ( VEGF receptors ) and tie 2 ( Ang 1 receptor ) induced by ang 2 was significantly suppressed by PD 123319 . ^^^ CONCLUSIONS : These results demonstrate that an infusion of ang 2 induced the expression of VEGF mainly through AT 1 receptors , and increased the expression of VEGF receptors , tie 2 , and Ang1 / Ang2 ratio mainly through AT 2 receptors . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
Because the endogenous agonist ANGPT 1 , antagonist ANGPT 2 , and TEK are expressed in the primate ovary , experiments were designed to investigate their role at a critical time during tissue remodeling / angiogenesis in the menstrual cycle ( i . e . , at midcycle during maturation , ovulation , and luteinization of the dominant follicle ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
ANGPT 1 and ANGPT 2 are ligands for TIE family receptor tyrosine kinases , TIE 1 and TIE 2 ( TEK ) . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.0
In addition , changes in mRNA expression for VEGF , Flt and KDR were positively correlated with changes in ANGPT 2 , Tie 2 , and NOS 3 , indicating a functional relationship . ^^^
Interacting proteins: O15123 and Q02763	Pubmed	SVM Score :0.72245931
Although Ang 2 was unable to induce significant Tie 2 receptor phosphorylation during a 5 min exposure , a 24 h pretreatment with Ang 2 , followed by brief re exposure , produced Tie 2 phosphorylation in HUVEC comparable to that produced by Ang1 * . 0.72245931^^^