| Interacting proteins: Q92985 and O15111 |
Pubmed |
SVM Score :0.0 |
| Both IkappaB kinase and PKR have been implicated in IFN induction , but cells genetically deficient in IkappaB kinase , PKR , or the PKR related genes PERK , IRE 1 , or GCN 2 retained the ability to phosphorylate IRF 7 and induce IFNalpha . ^^^ |
|
| Interacting proteins: Q92985 and O15111 |
Pubmed |
SVM Score :0.0 |
| We report here that the IkappaB kinase ( IKK ) related kinases IKKepsilon and TANK binding kinase 1 are components of the virus activated kinase that phosphorylate IRF 3 and IRF 7 . ^^^ |
|
| Interacting proteins: Q92985 and O15111 |
Pubmed |
SVM Score :0.0 |
| Virus induced expression of interferon ( IFN ) A genes is regulated by two members of the IFN regulatory factor ( IRF ) family , IRF 3 and IRF 7 , which are activated by phosphorylation during viral infection by the IKK related serine / threonine kinases TBK 1 and IkappaB kinase epsilon ( IKKepsilon ) . ^^^ |
|
| Interacting proteins: Q92985 and O15111 |
Pubmed |
SVM Score :0.0 |
| Kinase deficient IKK alpha inhibited the ability of MyD 88 to activate the Ifna promoter in synergy with IRF 7 . ^^^ Furthermore , IKK alpha associated with and phosphorylated IRF 7 . ^^^ |
|
| Interacting proteins: Q92985 and O15111 |
Pubmed |
SVM Score :0.0 |
| An inducible kinase , IKK i / IKKepsilon , related to the catalytic forms of the IkappaB kinase , has been studied as an anti viral , innate immune regulator through its ability to control the activity of the transcription factors IRF 3 and IRF 7 . ^^^ |
|
| Interacting proteins: Q92985 and O15111 |
Pubmed |
SVM Score :0.0 |
| Interestingly , these viral recognition pathways converge on TRAF 3 , which induces interferon through the activation of IRF 3 or IRF 7 by the TBK 1 and IKKi complexes . ^^^ |
|
| Interacting proteins: Q92985 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92985 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92985 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|