| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :1.1217543 |
| TANK was previously shown to assist NF kappa B activation in a complex with TANK binding kinase 1 ( TBK 1 ) or IKK epsilon , two kinases distantly related to IKK alpha / beta , but the underlying mechanisms remained unknown . 1.1217543^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| RESULTS : 1 TRAF / TANK was isolated as a molecule that interacts specifically with inducible IkappaB kinase ( IKK 1 ) by the yeast two hybrid screening procedure . ^^^ NF kappaB activation through IKK 1 dependent 1 TRAF / TANK phosphorylation . ^^^ The association of IKK 1 and 1 TRAF is mediated via the interaction between the N terminal domain of 1 TRAF and the C terminal portion of IKK 1 . ^^^ In vitro kinase assays demonstrate that IKK 1 phosphorylates 1 TRAF in the middle portion that associates with TRAF 2 . ^^^ NF kappaB activation by IKK 1 is significantly blocked by coexpression of the N terminal domain of 1 TRAF , dominant negative TRAF 2 , and dominant negative NIK and IKK beta . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| Recent studies of human cell lines in culture have implicated two noncanonical IkappaB kinase ( IKK ) related kinases , IKK epsilon and Traf family member associated NF kappaB activator ( TANK ) binding kinase 1 ( TBK 1 ) , in the phosphorylation of IRF 3 . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| TRAF 2 plays a dual role in NF kappaB dependent gene activation by mediating the TNF induced activation of p 38 MAPK and IkappaB kinase pathways . ^^^ |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| TNFRI has been recently shown to activate NF kappaB through association with TRADD , RIP , and TRAF 2 ; activation of the NF kappaB inducing kinase ( NIK ) ; activation of the IkappaB alpha kinases ( IKKalpha and IKKbeta ) ; and phosphorylation of IkappaB alpha . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| TNF alpha signaling involves the recruitment of at least three proteins ( TRADD , RIP , and TRAF 2 ) to the type 1 TNF alpha receptor tail , leading to the sequential activation of the downstream NF kappaB inducing kinase ( NIK ) and IkappaB specific kinases ( IKKalpha and IKKbeta ) . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| FADD , Casper , and caspase 8 induced NF kappaB activation are inhibited by dominant negative mutants of TRAF 2 , NIK , IkappaB kinase alpha , and IkappaB kinase beta . ^^^ |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| We observed that overexpression of OX 40 activated NF kappaB , which was inhibited by dominant negative forms of TRAF 2 , NF kappaB inducing kinase ( NIK ) , and IkappaB kinase ( IKK ) alpha . ^^^ TRAF 3 blocked OX 40 , TRAF 2 induced NF kappaB activation , but not NIK and IKKalpha induced NF kappaB activation , indicating that TRAF 3 blocks the pathway between TRAF 2 and NIK . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| In transfection experiments , effects of dominant negative IkappaBalpha , IKKalpha , IKKbeta , NF kappaB inducing kinase ( NIK ) , TRAF 2 , and TRAF 6 mutants were investigated . ^^^ CONCLUSIONS : H . pylori induces NF kappaB activation through an intracellular signaling pathway that involves IKKalpha , IKKbeta , NIK , TRAF 2 , and TRAF6 . . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| Our data show that TRX treatment inhibits NF kappaB dependent transcription at the level of downstream of TRAFs and upstream of NIK : TRX inhibited TRAF 2 , TRAF 5 , and TRAF 6 induced NF kappaB activation but does not inhibit NIK , IKKalpha , and MEKK induced activation . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| The alpha and beta subunits of IkappaB kinase ( IKK ) mediate TRAF 2 dependent IKK recruitment to tumor necrosis factor ( TNF ) receptor 1 in response to TNF . ^^^ We found that the IKKalpha and IKKbeta catalytic subunits are required for IKK TRAF 2 interaction . ^^^ This interaction occurs through the leucine zipper motif common to IKKalpha , IKKbeta , and the RING finger domain of TRAF 2 , and either IKKalpha or IKKbeta alone is sufficient for the recruitment of IKK to TNF R 1 . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| We aimed to investigate the dynamics of the NF kappaB signaling pathway in living cells using GFP variants of p 65 NF kappaB , IkappaBalpha , tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , the NF kappaB inducing kinase ( NIK ) and IkappaB kinases ( IKK 1 and IKK 2 ) . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| When overexpressed , NS5A can not inhibit the recruitment of TNF receptor associated factor 2 ( TRAF 2 ) and IkappaB kinase ( IKK ) beta into the TNF receptor 1 TNF receptor associated death domain complex . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| PAN 2 also suppressed NF kappaB induction resulting from overexpression of several adapter proteins and protein kinases involved in the TNF or IL 1 receptor signal transduction , including TRAF 2 , TRAF 6 , RIP , IRAK 2 , and NF kappaB inducing kinase as well as the IkappaB kinases IKKalpha and IKKbeta . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| Reporter assay with dominant negative mutants of TRAFs reveals that TRAF 2 , 3 , and 5 , as well as the downstream signal molecules NIK , IKKalpha , and IKKbeta , are involved in IL 8 gene expression . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| TRAIL induced NF kappaB activation was preceded by IkappaBalpha kinase ( IKK ) activation and IkappaBalpha degradation and depended on TRAF 2 , NF kappaB inducing kinase ( NIK ) , IKK 1 , and IKK 2 . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| TNFalpha activation of the NF kappaB pathway is associated with the inducible binding of TAK 1 to TRAF 2 and both IKKalpha and IKKbeta . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| Introduction of the dominant negative mutant of IkappaB kinase , of NFkappaB inducing kinase , and of tumour necrosis factor receptor associated factor 6 ( TRAF 6 ) , but not that of TRAF 2 , inhibited gastrin induced activation of NFkappaB . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| Of note , TNF induced NF kappaB DNA binding activity and activation of IkappaB kinases ( IKKs ) were markedly impaired in FAK / cells , whereas the expression of TNF receptor 1 or other signaling molecules such as receptor interacting protein ( RIP ) , tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , IKKalpha , IKKbeta , and IKKgamma was unchanged . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| Genetic studies have revealed that RIP 1 links the TNFR 1 to the IkappaB kinase ( IKK ) complex , whereas TRAF 2 couples the TNFR 1 to the SAPK / JNK cascade . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| We now use cells lacking expression of TRAF 2 , TRAF 5 , TRAF 6 , IKKalpha , IKKbeta , IKKgamma , TAB 2 , IL 1 receptor associated kinase ( IRAK ) 1 , or IRAK 4 to assess their roles in LMP 1 mediated NF kappaB activation . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| The kinase activity of Rip 1 is not required for tumor necrosis factor alpha induced IkappaB kinase or p 38 MAP kinase activation or for the ubiquitination of Rip 1 by Traf 2 . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| In mammalian cells , TNAP physically interacts with NIK , TRAF 2 , and TRAF 3 but not IKK 1 or IKK 2 . ^^^ TNAP specifically inhibits NF kappaB activation induced by tumor necrosis factor ( TNF ) alpha , TNF receptor 1 , TRADD , RIP , TRAF 2 , and NIK but does not affect IKK 1 and IKK 2 mediated NF kappaB activation . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| Coexpression of IkappaBalpha , IkappaBbeta , IKKalpha , IKKbeta , NIK and TRAF 2 dominant negative constructs , with LMP 1 inhibited the activation of the CCL 5 promoter by LMP 1 , suggesting that LMP 1 induces CCL 5 via NF kappaB signaling . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| Some TRAF proteins , such as TRAF 2 and TRAF 3 , have recently been shown to have a positive role in the canonical pathway that activates nuclear factor kappaB ( NF kappaB ) through IkappaB kinase beta ( IKKbeta ) , but a negative role in the noncanonical pathway that activates NF kappaB through IKKalpha . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| In these cells , LIGHT causes the recruitment of TRAF 2 , TRAF 3 , and IkappaB kinase into the LTbetaR complex . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| TRAF 2 , but not TRAF 3 , mediates the association of vFLIP with the IkappaB kinase complex . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| Furthermore , receptor activator of nuclear factor kappaB ( RANK ) induced the recruitment of tumor necrosis factor ( TNF ) associated factors 2 and 6 ( TRAF 2 and 6 , respectively ) to the cytoplasmic tail of RANKL with activated IkappaB kinase and IkappaB phosphorylation , while D PDMP treatment inhibited RANKL and induced IkappaB phosphorylation , and that inhibition was recovered by LacCer . ^^^ |
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| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|