| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| The cellular and viral CLAPs induce apoptosis downstream of caspase 8 by activating the Apaf 1 caspase 9 pathway and activate NF kappaB by acting upstream of the NF kappaB inducing kinase , NIK , and the IkB kinase , IKKalpha . ^^^ |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| FADD , Casper , and caspase 8 induced NF kappaB activation are inhibited by dominant negative mutants of TRAF 2 , NIK , IkappaB kinase alpha , and IkappaB kinase beta . ^^^ |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 can interact with multiple proteins known to be involved in the activation of the NF kappaB pathway , including the serine threonine kinases RIP , NIK , IKK 1 and IKK 2 . ^^^ |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| Until recently , most studies of the two pathways have solely focused on the core signaling complexes that are shared by the different receptors : death inducing complexes containing the cysteine proteases caspase 8 and caspase 10 , bound to the adapter protein MORT1 / FADD ( mediator of receptor induced toxicity / Fas associated DD protein ) , and the NF kappaB activating complex , composed of the protein kinases IKK 1 ( IkappaB kinase 1 ) and IKK 2 ( IkappaB kinase 2 ) and the regulatory subunit NEMO ( NF kappaB essential modulator ; the ' IKK signalosome ' ) . ^^^ |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 and caspase 10 activate NF kappaB through RIP , NIK and IKKalpha kinases . ^^^ Taken together , these results suggest that caspase 8 and 10 have roles in a non or anti apoptotic signaling pathway leading to NF kappaB activation through RIP , NIK and IKKalpha . . ^^^ |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| IKK inhibition by a small molecule inhibitor or by the knockdown of IKKalpha , IKKbeta , or RelA / p65 using siRNA , but not the inhibition of JNK , MEK , p 38 , or caspase 8 pathways , blocked TNFalpha induced G ( 0 ) G ( 1 ) arrest and restored sensitivity to FdUrd of drug resistant cells . ^^^ |
|
| Interacting proteins: Q14790 and O15111 |
Pubmed |
SVM Score :0.0 |
| Recruitment of the IKKalpha , beta complex , its activation , and the nuclear translocation of NF kappaB require enzyme activity of full length caspase 8 . ^^^ |
|