| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| Dominant active MEKK 1 also induced transfected IKK beta , but not IKK alpha , activity . ^^^ |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| Parthenolide targets a component of the 1 kappa B kinase complex without directly inhibiting IKK alpha , IKK beta , or MEKK 1 . ^^^ |
|
| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| Moreover , both IKK alpha and beta were activated by hematopoietic progenitor kinase 1 ( HPK 1 ) and MAPK / ERK kinase kinase 1 ( MEKK 1 ) specifically , suggesting that IkappaB / NF kappaB is regulated through the HPK 1 MEKK1 stress response signaling pathway . . ^^^ |
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| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| By contrast , overexpression of NIK stimulates kinase activities of both IKKalpha and IKKbeta comparably , suggesting a qualitative difference between NIK and MEKK 1 mediated NF kappaB activation pathways . ^^^ Collectively , these results indicate that NIK and MEKK 1 independently activate the IKK complex and that the kinase activities of IKKalpha and IKKbeta are differentially regulated by two upstream kinases , NIK and MEKK 1 , which are responsive to distinct stimuli . . ^^^ |
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| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| HTLV 1 Tax protein binds to MEKK 1 to stimulate IkappaB kinase activity and NF kappaB activation . ^^^ We show that Tax binds to the amino terminus of the protein kinase MEKK 1 , a component of an IkappaB kinase complex , and stimulates MEKK 1 kinase activity . ^^^ |
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| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| MEKK 1 activates both IkappaB kinase alpha and IkappaB kinase beta . ^^^ We have previously shown that mitogen activated protein kinase / ERK kinase kinase 1 ( MEKK 1 ) can induce both this site specific phosphorylation of IkappaB alpha at Ser 32 and Ser 36 in vivo and the activity of a high molecular weight IkappaB kinase complex in vitro . ^^^ Finally , we show that IKK alpha is present in the MEKK 1 inducible , high molecular weight IkappaB kinase complex and treatment of this complex with MEKK 1 induces phosphorylation of IKK alpha in vitro . ^^^ We also show that MEKK 1 can induce the activation of both IKK alpha and IKK beta in vivo . ^^^ |
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| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| MEKK 1 interacts with and stimulates the activities of both IKKalpha and IKKbeta in transfected HeLa and COS 1 cells and directly phosphorylates the IKKs in vitro . ^^^ |
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| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| This requirement for kinase proficient IKKalpha to activate IKKbeta in heterodimeric IKK signalsomes is also observed with other NF kappaB inducers , including tumor necrosis factor alpha , human T cell leukemia virus type 1 Tax , Cot , and MEKK 1 . ^^^ |
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| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| MEKK 1 activates IRF 3 through the c JUN amino terminal kinase ( JNK ) pathway but not the p 38 and IkappaB kinase ( IKK ) pathway . ^^^ |
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| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| MEKK 1 is also essential for induction of embryonic stem cell migration by serum factors , but is not required for activation of other MAPKs or the IkappaB kinase signaling cascade . . ^^^ |
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| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| Messenger RNA was detected for IkappaBalpha , and IkappaB kinase gamma ( IKKgamma , a scaffolding protein ) and the protein kinases , IKKalpha , IKKbeta , NF kappaB inducing kinase ( NIK ) , mitogen activated protein kinase Erk kinase kinase 1 ( MEKK 1 ) and TANK binding kinase 1 ( TBK 1 ) using real time quantitative polymerase chain reaction ( PCR ) . ^^^ Differential expression of NF kappaB pathway intermediates occurred when progesterone concentrations increased in early pregnancy ; IKKalpha and NIK mRNA levels increased in decidua whilst IKKbeta and MEKK 1 mRNA levels declined . ^^^ |
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| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| HCl also suppressed NF kappaB enhanced gene expression induced by Rac 1 , Cdc 42 , MEKK 1 , inhibitor of nuclear factor kappaalpha ( IKKalpha ) , IKKbeta , and a subunit of NF kappaB , p 65 . ^^^ |
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| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| Searching for molecules that couple TCR and CD 28 to MEKK 1 , we found that the guanine nucleotide exchange factor Vav synergized with CD 28 stimulation in Jurkat cells to induce NF kappaB transcriptional activity through the activation of IKKalpha and IKKbeta . ^^^ |
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| Interacting proteins: Q13233 and O15111 |
Pubmed |
SVM Score :0.0 |
| The activation of both IKKs and NF kappaB by Lf is over ridden by the expression of dominant negative mutants of NIK , MEKK 1 , IKKalpha and IKKbeta . ^^^ |
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