| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| Finally , overexpression of NF kappaB inducing kinase , a kinase that has recently been shown to induce p 100 processing , possibly through IKKalpha activation , causes nuclear translocation of RelB protein . ^^^ Thus , these studies indicate that p 100 is a bone fide inhibitor of RelB and that this transcription factor may be regulated by NF kappaB inducing kinase and / or IKKalpha . . ^^^ |
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| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| LTbetaR induced binding of p 52 RelB requires the degradation of the inhibitory p 52 precursor , p 100 , which is mediated by the NF kappaB inducing kinase ( NIK ) and the IkappaB kinase ( IKK ) complex subunit IKKalpha , but not IKKbeta or IKKgamma . ^^^ Our data indicate an important role of p 52 RelB heterodimers in lymphoid organ development downstream of LTbetaR , NIK and IKKalpha . . ^^^ |
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| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| The alternative or second pathway proceeded via NF kappaB inducing kinase ( NIK ) , IKKalpha , and protein synthesis dependent processing of the inhibitory NF kappaB 2 p100 precursor protein to the p 52 form and resulted in a delayed but sustained activation of primarily RelB containing NF kappaB dimers . ^^^ |
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| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| LTbetaR induced binding of RelB / p50 requires processing of p 100 that is mediated by IKKalpha but is independent of IKKbeta , NEMO / IKKgamma , and RelA . ^^^ |
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| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| IkappaB Kinase ( IKK ) alpha is required for activation of an alternative NF kappaB signaling pathway based on processing of the NF kappaB2 / p100 precursor protein , which associates with RelB in the cytoplasm . ^^^ Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB : p 52 dimers . ^^^ We identified in the IKKalpha dependent promoters a novel type of NF kappaB binding site that is preferentially recognized by RelB : p 52 dimers . ^^^ |
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| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| Recent studies revealed that the lymphotoxin / lymphotoxin beta receptor ( LT ) / LTbetaR system activates the noncanonical nuclear factor kappaB ( NF kappaB ) signaling pathway involving 1 kappa B kinase 1 / I kappa B kinase alpha ( IKK1 / IKKalpha ) and NF kappaB inducing kinase ( NIK ) to direct processing of the nfkappab 2 protein p 100 to yield RelB : p 52 complexes . ^^^ |
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| Interacting proteins: Q01201 and O15111 |
Pubmed |
SVM Score :0.0 |
| Activation of IKKalpha and NF kappaB inducing kinase was detected by d5 . 5 , implicating the alternative NF kappaB signaling pathway in RelB / p52 induction . ^^^ Constitutively active IKKalpha induced p 52 , RelB , and cyclin D 1 in untransformed mammary epithelial cells . ^^^ |
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