| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| This requirement for kinase proficient IKKalpha to activate IKKbeta in heterodimeric IKK signalsomes is also observed with other NF kappaB inducers , including tumor necrosis factor alpha , human T cell leukemia virus type 1 Tax , Cot , and MEKK 1 . ^^^ |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| PKC theta activation of NF kappaB is mediated through the selective induction of IKKbeta , while the Cot and NIK dependent pathway involves induction of both IKKalpha and IKKbeta . . ^^^ |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| Mutation of S 400 in Cot does indeed abolish its ability to activate 1 kappa B kinase ( IKK ) complexes , but paradoxically it allows for increased Cot association with the IKK complex . ^^^ |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| Pim 2 activates NF kappaB dependent gene expression by inducing phosphorylation of the oncogenic serine / threonine kinase Cot , leading to both augmentation of IkappaB kinase activity and a shift in nuclear NF kappaB from predominantly p 50 homodimers to p50 / p65 heterodimers . ^^^ |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| The protein kinase COT / Tpl2 is activated by interleukin 1 ( IL 1 ) , TNFalpha and lipopolysaccharide , and its activation by these agonists involves the IkappaB kinase beta ( IKKbeta ) catalysed phosphorylation of the p 105 regulatory subunit . ^^^ |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| IkappaB kinase is an essential component of the Tpl 2 signaling pathway . ^^^ Using IKK deficient murine fibroblasts , we further demonstrate that IKKbeta , but not IKKalpha , is required for Tpl 2 activation . ^^^ |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| Lipopolysaccharide activation of the TPL 2 / MEK / extracellular signal regulated kinase mitogen activated protein kinase cascade is regulated by IkappaB kinase induced proteolysis of NF kappaB 1 p105 . ^^^ Activation of TPL 2 , MEK , and ERK by LPS is also demonstrated to require proteasome mediated proteolysis . p 105 is known to be proteolysed by the proteasome following stimulus induced phosphorylation of two serines in its PEST region by the IkappaB kinase ( IKK ) complex . ^^^ |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P41279 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|