| Interacting proteins: P19525 and O15111 |
Pubmed |
SVM Score :0.0 |
| NF kappaB activation by double stranded RNA activated protein kinase ( PKR ) is mediated through NF kappaB inducing kinase and IkappaB kinase . ^^^ Here we show that in response to poly ( rI ) . poly ( rC ) ( pIC ) , PKR activates IkappaB kinase ( IKK ) , leading to the degradation of the inhibitors IkappaBalpha and IkappaBbeta and the concomitant release of NF kappaB . ^^^ |
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| Interacting proteins: P19525 and O15111 |
Pubmed |
SVM Score :0.0 |
| Activation of NF kappa B by the dsRNA dependent protein kinase , PKR involves the 1 kappa B kinase complex . ^^^ Our findings demonstrate that physiological function ( s ) of PKR involve activation of the 1 kappa B kinase complex . ^^^ Expression by 10 recombinants of IKK 1 or IKK 2 dominant negative mutants together with PKR showed inhibition of PKR induced NF kappa B activation , as measured both by gel shift and luciferase reporter assays . ^^^ |
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| Interacting proteins: P19525 and O15111 |
Pubmed |
SVM Score :0.0 |
| PKR stimulates NF kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex . ^^^ |
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| Interacting proteins: P19525 and O15111 |
Pubmed |
SVM Score :0.0 |
| Both IkappaB kinase and PKR have been implicated in IFN induction , but cells genetically deficient in IkappaB kinase , PKR , or the PKR related genes PERK , IRE 1 , or GCN 2 retained the ability to phosphorylate IRF 7 and induce IFNalpha . ^^^ |
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| Interacting proteins: P19525 and O15111 |
Pubmed |
SVM Score :0.0 |
| Recent studies have identified an expanding network of PKR signaling partners , including signal transducers and activators of transcription 1 ( STAT 1 ) , p 53 , and IkappaB kinase . ^^^ |
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| Interacting proteins: P19525 and O15111 |
Pubmed |
SVM Score :0.0 |
| PKR is a component of the inhibitor of kappaB ( IkappaB ) kinase complex and plays either a catalytic or structural role in the activation of IkappaB kinase , depending on the stimulus . ^^^ |
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| Interacting proteins: P19525 and O15111 |
Pubmed |
SVM Score :0.0 |
| The double stranded RNA ( dsRNA ) dependent protein kinase PKR activates NF kappa B via the 1 kappa B kinase ( IKK ) complex , but little is known about additional molecules that may be involved in this pathway . ^^^ |
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| Interacting proteins: P19525 and O15111 |
Pubmed |
SVM Score :0.0 |
| PKR is also involved in the activation of nuclear factor kappaB ( NFkappaB ) through activation of the IkappaB kinase complex . ^^^ |
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| Interacting proteins: P19525 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P19525 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
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