| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| The CARD domains of both CARD 11 and CARD 14 associate specifically with the CARD domain of BCL 10 , a signaling protein that activates NF kappaB through the IkappaB kinase complex in response to upstream stimuli . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| Here , we show that hTid 1 represses NF kappaB activity induced by Tax as well as other activators such as tumor necrosis factor alpha ( TNFalpha ) and Bcl 10 . hTid 1 specifically suppresses serine phosphorylation of IkappaBalpha by activated IkappaB kinase beta ( IKKbeta ) , but the activities of other serine kinases including p 38 , ERK 2 , and JNK 1 are not affected . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| CARD 11 functions upstream of the IkappaB kinase ( IKK ) complex and cooperates with Bcl 10 in a CARD domain dependent manner . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| Paracaspase acts downstream of Bcl 10 to induce NF kappaB activation and is required for the normal development of B cells , indicating that paracaspase provides the missing link between Bcl 10 and activation of the IkappaB kinase complex . . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| Downstream from PKCtheta , the caspase recruitment domain ( CARD ) proteins CARD11 / CARMA1 and Bcl 10 relay T cell receptor derived signals to the IkappaB kinase ( IKK ) complex . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| CD3 / CD28 costimulation induced NF kappaB activation is mediated by recruitment of protein kinase C theta , Bcl 10 , and IkappaB kinase beta to the immunological synapse through CARMA 1 . ^^^ Although CD3 / CD28 costimulation effectively induces the formation of the immunological synapse in CARMA 1 deficient T cells , the recruitment of protein kinase C theta ( PKC theta ) , Bcl 10 , and IkappaB kinase beta ( IKKbeta ) into lipid rafts of the immunological synapse is defective . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| Bcl 10 overexpression is sufficient to activate NF kappaB , a process that requires the NF kappaB essential modulator NEMO ( also known as IKK gamma ) , which is the regulatory subunit of the IkappaB kinase complex . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| BCR signaling leads to activation of the inhibitor of NF kappa B kinase ( IKK ) complex via Carma 1 , Bcl 10 and MALT 1 , whereas BAFF R engagement promotes processing of NF kappa B 2 protein p 100 , which is dependent on NF kappa B inducing kinase ( NIK ) and IKK alpha . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| The CARD domain protein BCL 10 and paracaspase MALT 1 are essential for the activation of IkappaB kinase ( IKK ) and NF kappaB in response to T cell receptor ( TCR ) stimulation . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| Herein , we demonstrate that BCL 10 , a critical molecule that signals between the T cell receptor and IkappaB kinase complexes , is involved in the innate immune system and is required for appropriate TLR 4 pathway and nuclear factor kappaB ( NF kappaB ) activation . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| The basal expression of the IkappaB kinase beta ( IKK beta ) gene and that of the BCL 10 ( L ) gene were also higher in TR than in C rats . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| Recent reports have elucidated a signaling pathway that involves the protein kinase C ( PKC ) , the scaffold protein CARD 11 ( also called CARMA 1 ) , the caspase recruitment domain ( CARD ) containing protein Bcl 10 , and the paracaspase ( protease related to caspases ) MALT 1 as critical intermediates linking the TCR to the IkappaB kinase ( IKK ) complex . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| T cell receptor ( TCR ) signaling to IkappaB kinase ( IKK ) / NF kappaB is controlled by PKCtheta dependent activation of the Carma 1 , Bcl 10 , and Malt 1 ( CBM ) complex . ^^^ |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95999 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|