| Interacting proteins: O95163 and O15111 |
Pubmed |
SVM Score :0.0 |
| The autosomal recessive disorder familial dysautonomia ( FD ) has recently been demonstrated to be caused by mutations in the IKBKAP gene , so named because an initial report suggested that it encoded an IkappaB kinase complex associated protein ( IKAP ) . ^^^ |
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| Interacting proteins: O95163 and O15111 |
Pubmed |
SVM Score :0.0 |
| Mutations in the IkappaB kinase complex associated protein ( IKBKAP ) gene cause FD . ^^^ |
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| Interacting proteins: O95163 and O15111 |
Pubmed |
SVM Score :0.0 |
| Familial dysautonomia ( FD ) , a neurodegenerative genetic disorder primarily affecting individuals of Ashkenazi Jewish descent , is caused by mutations in the IKBKAP gene which encodes the IkappaB kinase complex associated protein ( IKAP ) . ^^^ |
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| Interacting proteins: O95163 and O15111 |
Pubmed |
SVM Score :0.0 |
| The diagnosis was confirmed by the demonstration of mutations in the IkappaB kinase complex associated protein gene with the identification of IVS 20 ( +6T > C ) which is responsible for more than 99 . 5 % of known Ashkenazi Jewish patients with familial dysautonomia . ^^^ |
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| Interacting proteins: O95163 and O15111 |
Pubmed |
SVM Score :0.0 |
| IKAP is a scaffold protein of the IkappaB kinase complex . ^^^ |
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| Interacting proteins: O95163 and O15111 |
Pubmed |
SVM Score :0.0 |
| The 1 kappa B kinase ( IKK ) complex is tripartite and contains IKK gamma but not IKAP as a regular component . ^^^ IKK alpha and IKK beta are the two catalytic subunits of the IKK complex and two additional molecules , IKK gamma / NEMO and IKAP , have been described as further integral members . ^^^ |
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| Interacting proteins: O95163 and O15111 |
Pubmed |
SVM Score :0.0 |
| We identified and characterized the RNAs encoded by this region of chromosome 9 in cell lines derived from individuals homozygous for the major FD haplotype , and we observed that the RNA encoding the IkappaB kinase complex associated protein ( IKAP ) lacks exon 20 and , as a result of a frameshift , encodes a truncated protein . ^^^ |
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| Interacting proteins: O95163 and O15111 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here a novel role for the 1 kappa B kinase complex associated protein ( IKAP ) in the regulation of activation of the mammalian stress response via the c Jun N terminal kinase ( JNK ) signaling pathway . ^^^ |
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| Interacting proteins: O95163 and O15111 |
Pubmed |
SVM Score :0.0 |
| We recently identified a mutation in the 1 kappa B kinase associated protein ( IKBKAP ) gene as the major cause of familial dysautonomia ( FD ) , a recessive sensory and autonomic neuropathy . ^^^ |
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| Interacting proteins: O95163 and O15111 |
Pubmed |
SVM Score :0.0 |
| This study compared the effect of these stimuli on endogenous IkappaB kinase ( IKK ) signalsome activation and IkappaB phosphorylation / proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK alpha , IKK beta , NF kappaB inducing kinase ( NIK ) , IKK gamma ( NF kappaB essential modulator ) , and IKK complex associated protein . ^^^ |
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| Interacting proteins: O95163 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
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