| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| Leukemia associated Rho guanine nucleotide exchange factor ( LARG ) belongs to the subfamily of Dbl homology RhoGEF proteins ( including p 115 RhoGEF and PDZ RhoGEF ) that possess amino terminal regulator of G protein signaling ( RGS ) boxes also found within GTPase accelerating proteins ( GAPs ) for heterotrimeric G protein alpha subunits . p 115 RhoGEF stimulates the intrinsic GTP hydrolysis activity of G alpha 12 / 13 subunits and acts as an effector for G 13 coupled receptors by linking receptor activation to RhoA activation . ^^^ Our findings suggest that the RhoA exchange factor LARG , unlike the related p 115 RhoGEF and PDZ RhoGEF proteins , can serve as an effector for Gq coupled receptors , mediating their functional linkage to RhoA dependent signaling pathways . . ^^^ |
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| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| Plexin B 1 directly interacts with PDZ RhoGEF / LARG to regulate RhoA and growth cone morphology . ^^^ Activation of plexin B 1 by semaphorin 4D regulates PDZ RhoGEF / LARG activity leading to RhoA activation . ^^^ |
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| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| Recent studies have demonstrated that Plexin B 1 activates RhoA and induces growth cone collapse through Rho specific guanine nucleotide exchange factor PDZ RhoGEF . ^^^ The Sema4D induced contraction in Plexin B1 / Rnd1 expressing COS 7 cells was suppressed by dominant negative RhoA , a Rho associated kinase inhibitor , a dominant negative form of PDZ RhoGEF , or deletion of the carboxyl terminal PDZ RhoGEF binding region of Plexin B 1 , indicating that the PDZ RhoGEF / RhoA / Rho associated kinase pathway is involved in this morphological effect . ^^^ We also found that Rnd 1 promoted the interaction between Plexin B 1 and PDZ RhoGEF and thereby dramatically potentiated the Plexin B 1 mediated RhoA activation . ^^^ |
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| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| The regulator of G protein signaling ( RGS ) containing RhoGEFs , including p115RhoGEF , PDZ RhoGEF , and LARG , represent a novel family of guanine nucleotide exchange factors for RhoA that are regulated by the Galpha ( 12 / 13 ) family of heterotrimeric G proteins . ^^^ |
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| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| New crystal structures of the DH PH domains from leukemia associated Rho guanine nucleotide exchange factor ( RhoGEF ) and PDZ RhoGEF bound to RhoA reveal how DH PH domains cooperate to specifically activate Rho GTPases . . ^^^ |
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| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| There are three Rho specific GEFs ( RhoGEFs ) in vascular smooth muscle that contain a binding domain [ regulator of G protein signaling ( RGS ) domain ] capable of linking GPCRs to RhoA activation : PDZ RhoGEF , leukemia associated RhoGEF ( LARG ) , and p115RhoGEF . ^^^ |
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| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| Using siRNA to suppress expression of the three known G protein alpha subunit associated RhoA guanine nucleotide exchange factors ( GEFs ) , we also show that two of these RhoA GEFs , PDZ RhoGEF and leukemia associated RhoGEF ( LARG ) , link bombesin receptors to RhoA in a non redundant manner in PC cells . ^^^ We next show that focal adhesion kinase , which activates PDZ RhoGEF and LARG , is required for bombesin stimulated RhoA activation . ^^^ |
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| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| We report here that KIAA 0380 , a protein with a tandem DH / PH domain , an amino terminal PDZ domain and a regulator of G protein signalling ( RGS ) homology domain , is a specific GEF for RhoA , but not for Rac 1 and Cdc 42 , as determined by GDP release , guanosine 5 ' O ( 3 thio ) triphosphate ( GTPgammaS ) binding and protein binding assays . ^^^ |
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| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15085 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
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