| Interacting proteins: O43157 and O15085 |
Pubmed |
SVM Score :0.0 |
| Plexin B 1 directly interacts with PDZ RhoGEF / LARG to regulate RhoA and growth cone morphology . ^^^ Activation of plexin B 1 by semaphorin 4D regulates PDZ RhoGEF / LARG activity leading to RhoA activation . ^^^ |
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| Interacting proteins: O43157 and O15085 |
Pubmed |
SVM Score :0.0 |
| Moreover , overexpression of the PDZ domain of PDZ RhoGEF but not its regulator of G protein signaling domain prevents cell rounding and neurite retraction of differentiated PC 12 cells induced by activation of endogenous Plexin B 1 by semaphorin 4D . ^^^ |
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| Interacting proteins: O43157 and O15085 |
Pubmed |
SVM Score :0.0 |
| Both KIAA 0380 and LARG could bind plexin B 1 and a deletion mutant analysis of plexin B 1 , KIAA 0380 and LARG revealed that KIAA 0380 and LARG bound plexin B 1 cytoplasmic tail through their PDZ domains . ^^^ The tissue distribution analysis indicated that plexin B 1 was co localized with KIAA 0380 and LARG in various tissues . ^^^ |
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| Interacting proteins: O43157 and O15085 |
Pubmed |
SVM Score :0.0 |
| Mutation of the carboxy terminal amino acids of plexin B 1 or coexpression of a dominant negative PDZ RhoGEF abrogated the ability of plexin B 1 to cause stress fiber formation . ^^^ |
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| Interacting proteins: O43157 and O15085 |
Pubmed |
SVM Score :0.0 |
| Direct interaction of Rnd 1 with Plexin B 1 regulates PDZ RhoGEF mediated Rho activation by Plexin B 1 and induces cell contraction in COS 7 cells . ^^^ Recent studies have demonstrated that Plexin B 1 activates RhoA and induces growth cone collapse through Rho specific guanine nucleotide exchange factor PDZ RhoGEF . ^^^ The Sema4D induced contraction in Plexin B1 / Rnd1 expressing COS 7 cells was suppressed by dominant negative RhoA , a Rho associated kinase inhibitor , a dominant negative form of PDZ RhoGEF , or deletion of the carboxyl terminal PDZ RhoGEF binding region of Plexin B 1 , indicating that the PDZ RhoGEF / RhoA / Rho associated kinase pathway is involved in this morphological effect . ^^^ We also found that Rnd 1 promoted the interaction between Plexin B 1 and PDZ RhoGEF and thereby dramatically potentiated the Plexin B 1 mediated RhoA activation . ^^^ |
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| Interacting proteins: O43157 and O15085 |
Pubmed |
SVM Score :0.0 |
| Instead , the use of chimeric plexin B 1 receptors , Rho inhibitors , and lentiviral gene delivery of interfering molecules revealed that these proangiogenic effects are dependent on a COOH terminal PDZ binding motif of plexin B 1 , which binds two guanine nucleotide exchange factors for the small GTPase Rho , PDZ RhoGEF and LARG , and are mediated by the activation of Rho initiated pathways . . ^^^ |
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| Interacting proteins: O43157 and O15085 |
Pubmed |
SVM Score :0.0 |
| NA |
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