| Interacting proteins: Q01658 and O14981 |
Pubmed |
SVM Score :0.0 |
| The BTAF 1 protein ( formerly known as TAF ( 2 ) 170 / TAF 172 and the human ortholog of Saccharomyces cerevisiae Mot1p ) and the NC 2 complex composed of NC2alpha ( DRAP 1 ) and NC2beta ( Dr 1 ) are able to bind to TBP directly and regulate RNA polymerase 2 transcription both positively and negatively . ^^^ |
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| Interacting proteins: Q01658 and O14981 |
Pubmed |
SVM Score :0.0 |
| Once TBP is bound to DNA , factors such as TAF ( 2 ) 250 and Mot 1 induce TBP to dissociate , while other factors such as NC 2 and the NOT complex convert the TBP / DNA complex into an inactive state . ^^^ |
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| Interacting proteins: Q01658 and O14981 |
Pubmed |
SVM Score :0.0 |
| The gene sets controlled by NC 2 and Srb 10 are strongly correlated with the Mot 1 controlled set , suggesting that these factors cooperate in transcriptional control on a global scale . . ^^^ |
|
| Interacting proteins: Q01658 and O14981 |
Pubmed |
SVM Score :0.0 |
| Mot 1 associates with transcriptionally active promoters and inhibits association of NC 2 in Saccharomyces cerevisiae . ^^^ Mot 1 inhibits the association of NC 2 with promoters , suggesting that the TBP Mot 1 and TBP NC 2 complexes compete for promoter occupancy in vivo . ^^^ |
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| Interacting proteins: Q01658 and O14981 |
Pubmed |
SVM Score :0.0 |
| Previous results demonstrated a large overlap in the gene sets controlled by Mot 1 and NC 2 . ^^^ Mot 1 and NC 2 can co occupy TBP . ^^^ DNA in vitro , and NC 2 binding does not impair Mot 1 catalyzed disruption of the complex . ^^^ |
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| Interacting proteins: Q01658 and O14981 |
Pubmed |
SVM Score :0.0 |
| In addition , other cofactors , such as TAF 1 , BTAF 1 , and negative cofactor 2 ( NC 2 ) , can also modulate TBP or TFIID binding to the core promoter . ^^^ |
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| Interacting proteins: Q01658 and O14981 |
Pubmed |
SVM Score :0.0 |
| NA |
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