| Interacting proteins: Q6PGQ7 and O14965 |
Pubmed |
SVM Score :0.0 |
| Mitotic activation of the kinase Aurora A requires its binding partner Bora . ^^^ Here , we describe the identification of Bora , a conserved protein that is required for the activation of Aurora A at the onset of mitosis . ^^^ In the Drosophila peripheral nervous system , bora mutants have defects during asymmetric cell division identical to those observed in aurora A . ^^^ Furthermore , overexpression of bora can rescue defects caused by mutations in aurora A . ^^^ Bora is conserved in vertebrates , and both Drosophila and human Bora can bind to Aurora A and activate the kinase in vitro . ^^^ |
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| Interacting proteins: Q6PGQ7 and O14965 |
Pubmed |
SVM Score :0.0 |
| Work by Knoblich and coworkers in this issue of Developmental Cell identifies the conserved protein , Aurora Borealis ( Bora ) , as a key regulator of Aurora A activity during mitosis . . ^^^ |
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