| Interacting proteins: Q14511 and O14965 |
Pubmed |
SVM Score :0.0 |
| We report here that overexpression of HEF 1 causes an increase in centrosome numbers and multipolar spindles , resembling defects induced by manipulation of the mitotic regulatory kinase Aurora A ( AurA ) . ^^^ We show that HEF 1 associates with and controls activation of AurA . ^^^ The focal adhesion scaffolding protein HEF 1 regulates activation of the Aurora A and Nek 2 kinases at the centrosome . ^^^ |
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| Interacting proteins: Q14511 and O14965 |
Pubmed |
SVM Score :0.0 |
| HEF 1 aurora A interactions : points of dialog between the cell cycle and cell attachment signaling networks . ^^^ Our recent work identifying HEF 1 as an activator of the Aurora A kinase suggests a novel hub for such integrated signaling . ^^^ |
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