| TACC 1 chTOG Aurora A protein complex in breast cancer . ^^^ We have delineated here the interactions of TACC 1 with four proteins , namely the microtubule associated chTOG ( colonic and hepatic tumor overexpressed gene ) protein ( ortholog of Drosophila MSPS ) , the adaptor protein TRAP ( tudor repeat associator with PCTAIRE 2 ) , the mitotic serine / threonine kinase Aurora A and the mRNA regulator LSM 7 ( Like Sm protein 7 ) . ^^^ To measure the relevance of the TACC 1 associated complex in human cancer we have examined the expression of the three TACC , chTOG and Aurora A in breast cancer using immunohistochemistry on tissue microarrays . ^^^ We show that expressions of TACC 1 , TACC 2 , TACC 3 and Aurora A are significantly correlated and downregulated in a subset of breast tumors . ^^^ |