Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.84481401
Here we report that TSG 101 interacts with hepatocyte growth factor regulated tyrosine kinase substrate ( HRS ) , an early endosomal protein , and that disruption of this interaction impedes endosomal trafficking and endocytosis mediated degradation of mitogenic receptors . 0.84481401^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
Here , we show that Hrs binds to the ESCRT 1 subunit Tsg 101 via a PSAP motif that is conserved in Tsg 101 binding viral proteins . ^^^ Even though Hrs mainly localizes to early endosomes and Tsg 101 to late endosomes , the two proteins colocalize on a subpopulation of endosomes that contain lyso bisphosphatidic acid . ^^^ Overexpression of Hrs causes accumulation of Tsg 101 on early endosomes and prevents its localization to late endosomes . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
The same motif is also found in Hrs and recruits the ESCRT 1 complex to endosomes through direct interaction with one of its components called TSG 101 . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
These observations with the preferential association of mutant CFTRs with Hrs , STAM 2 , TSG 101 , hVps 25 , and hVps 32 , components of the Ub dependent endosomal sorting machinery , establish a functional link between Ub modification and lysosomal degradation of misfolded CFTR from the cell surface . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
These results indicate that opioid receptors , despite their ability to undergo efficient agonist induced trafficking to lysosomes in the absence of covalent modification by ubiquitin , utilize some ( Vps 4 and Hrs ) but perhaps not all ( Tsg 101 ) of the VPS machinery required for lysosomal sorting of ubiquitinated membrane cargo . . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
Of the class E Vps proteins , both the ESCRT 1 complex ( composed of the class E proteins Vps 23 , 28 , and 37 ) and Vps 27 ( mammalian hepatocyte receptor tyrosine kinase substrate , Hrs ) have been shown to interact with ubiquitin , a signal for entry into the MVB pathway . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
Both tumor susceptibility gene 101 ( TSG 101 ) / human VPS ( hVPS ) 28 and hepatocyte growth factor receptor substrate ( Hrs ) cytosolic complexes bind ubiquitin agarose . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
Now , we report that Tsg 101 binds the COOH terminal region of the endosomal protein hepatocyte growth factor regulated tyrosine kinase substrate ( Hrs ; residues 222 777 ) . ^^^ HIV Gag mimics the Tsg 101 recruiting activity of the human Hrs protein . ^^^ This interaction is mediated , in part , by binding of the Tsg 101 UEV domain to the Hrs 348PSAP351 motif . ^^^ Importantly , Hrs 222 777 can recruit Tsg 101 and rescue the budding of virus like Gag particles that are missing native late domains . ^^^ These observations indicate that Hrs normally functions to recruit Tsg 101 to the endosomal membrane . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
Here , we show that a regulator of proliferation , hepatocellular carcinoma related protein 1 ( HCRP 1 ) , interacts with Tsg 101 , hVps 28 , and their upstream regulator Hrs . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
Drosophila cells with impaired Tsg 101 function show accumulation of the Notch receptor in intracellular compartments marked by the endosomal protein Hrs . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
An essential role for SNX 1 in lysosomal sorting of protease activated receptor 1 : evidence for retromer , Hrs , and Tsg 101 independent functions of sorting nexins . ^^^ However , activated PAR 1 degradation was not affected in cells depleted of retromer Vps26 / Vps35 subunits , Hrs or Tsg 101 , an Hrs interacting protein . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
Distinct roles for Tsg 101 and Hrs in multivesicular body formation and inward vesiculation . ^^^ Together , these results indicate that Tsg 101 is required for the formation of stable vacuolar domains within the early endosome that develop into MVBs and Hrs is required for the accumulation of internal vesicles within MVBs and that both these processes are up regulated by EGF stimulation . . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
Although these microdomains show little lateral diffusion in the membrane , they are dynamic structures that exchange Hrs and clathrin with similar kinetics , and acquire the downstream sorting component Tsg 101 . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
Clones of fab 1 mutant cells accumulate Wingless and Notch , similarly to cells lacking Hrs , Vps 25 , and Tsg 101 , components of the endosomal sorting machinery for ubiquitinated membrane proteins . ^^^ However , whereas hrs , vps 25 , and tsg 101 mutant cell clones accumulate ubiquitinated cargo , this is not the case with fab 1 mutants . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
VPS37C can form a ternary complex with Tsg 101 and VPS 28 by binding to a domain situated toward the carboxyl terminus of Tsg 101 and binds to another class E VPS factor , namely Hrs . ^^^ In addition , VPS37C is recruited to aberrant endosomes induced by overexpression of Tsg 101 , Hrs , or dominant negative form of the class E VPS ATPase , VPS 4 . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
Specifically , we found that the VHS domain of Tom1L1 interacts with Hrs ( Hepatocyte growth factor regulated tyrosine kinase substrate ) , whereas a PTAP motif , located between the VHS and GAT domain of Tom1L1 , is responsible for binding to TSG 101 ( tumor susceptibility gene 101 ) . ^^^
Interacting proteins: Q99816 and O14964	Pubmed	SVM Score :0.0
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