| Interacting proteins: Q13596 and O14964 |
Pubmed |
SVM Score :0.0 |
| Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor . ^^^ Here , we report that Hrs interacts with sorting nexin 1 ( SNX 1 ) , a recently identified mammalian homologue of yeast Vps5p that recognizes the lysosomal targeting code of epidermal growth factor receptor ( EGFR ) and participates in lysosomal trafficking of the receptor . ^^^ Biochemical analyses demonstrate that Hrs and SNX 1 are ubiquitous proteins that exist in both cytosolic and membrane associated pools , and that the association of Hrs and SNX occurs on cellular membranes but not in the cytosol . ^^^ Furthermore , endogenous SNX 1 and Hrs form a approximately 550 kDa complex that excludes EGFR . ^^^ Immunofluorescence and subcellular fractionation studies show that Hrs and SNX 1 colocalize on early endosomes . ^^^ |
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| Interacting proteins: Q13596 and O14964 |
Pubmed |
SVM Score :0.0 |
| An essential role for SNX 1 in lysosomal sorting of protease activated receptor 1 : evidence for retromer , Hrs , and Tsg 101 independent functions of sorting nexins . ^^^ SNX 1 is known to interact with components of the mammalian retromer complex and Hrs , an early endosomal membrane associated protein . ^^^ Together , our findings establish an essential role for endogenous SNX 1 in sorting activated PAR 1 to a distinct lysosomal degradative pathway that is independent of retromer , Hrs , and Tsg101 . . ^^^ |
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