| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.67174753 |
| Merlin interacts with HRS in the unfolded , or open , conformation . 0.67174753^^^ |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.5060617 |
| We verified the interaction by both immunoprecipitation of endogenous HRS with endogenous schwannomin in vivo as well as by using bacterially purified HRS and schwannomin in vitro . 0.5060617^^^ |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.67906822 |
| Schwannomin with the pathogenic missense mutation Q538P fails to bind HRS and does not inhibit Stat 5 phosphorylation . 0.67906822^^^ Previously we demonstrated that the hepatocyte growth factor regulated tyrosine kinase substrate ( HRS ) strongly interacts with schwannomin . 0.56901941^^^ |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| Ocular hypotensive responses were sustained for as long as 24 hrs following a single application of 0 . 001 % SCH 33861 . ^^^ |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| Merlin interacts with several proteins that might mediate merlin growth suppression , including hepatocyte growth factor regulated tyrosine kinase substrate ( HRS or HGS ) . ^^^ Previously , we demonstrated that regulated overexpression of HRS in RT 4 rat schwannoma cells had the same functional consequences as regulated overexpression of merlin . ^^^ To determine the functional significance of this interaction , we generated a series of HRS truncation mutants and defined the regions of HRS required for merlin binding and HRS growth suppression . ^^^ The HRS domain required for merlin binding was narrowed to a region ( residues 470 497 ) containing the predicted coiled coil domain whereas the major domain responsible for HRS growth suppression was distinct ( residues 498 550 ) . ^^^ To determine whether merlin growth suppression required HRS , we demonstrated that merlin inhibited growth in HRS ( + / + ) , but not HRS ( / ) mouse embryonic fibroblast cells . ^^^ |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| Lastly , we show that PAK 2 phosphorylation impairs the ability of merlin to bind to two interacting proteins , CD 44 and hepatocyte growth factor regulated tyrosine kinase substrate ( HRS ) , both critical for merlin growth suppression . ^^^ |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| Previously , we showed that schwannomin with missense mutations L360P , L535P , and Q538P alters interaction with betaII spectrin and Hrs . ^^^ Using yeast two hybrid tests of interaction , we now show the effects of 11 Nf 2 missense mutations on schwannomin self interaction as well as schwannomin interaction with Hrs isoforms 1 and 2 , betaII spectrin , and p 110 . ^^^ |
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| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| Previously , we identified HRS as a protein that interacts with the neurofibromatosis 2 tumor suppressor schwannomin . ^^^ Schwannomin inhibited EGF mediated Stat 3 activation , consistent with HRS and schwannomin interacting in the same signaling pathway . ^^^ |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| Amino acid sequence analysis of the Hdc protein revealed a region homologous to the human HRS proteins , which directly interact with the NF 2 tumor suppressor on experimental evidence . . ^^^ |
|
| Interacting proteins: P35240 and O14964 |
Pubmed |
SVM Score :0.0 |
| Pimozide and SCH 23390 continued to reduce ambulatory activity at the test 24 hrs after injection . ^^^ All drugs impaired motor coordination 1 hr after injection and , with the exception of SCH 23390 , were also effective at the 24 hrs test . ^^^ |
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