| Specifically , we found that the VHS domain of Tom1L1 interacts with Hrs ( Hepatocyte growth factor regulated tyrosine kinase substrate ) , whereas a PTAP motif , located between the VHS and GAT domain of Tom1L1 , is responsible for binding to TSG 101 ( tumor susceptibility gene 101 ) . ^^^ Tom1L1 ( Tom 1 like1 ) and related proteins Tom 1 ( Target of Myb 1 ) and Tom1L2 ( Tom 1 like2 ) constitute a new protein family characterized by the presence of a VHS ( Vps27p / Hrs / Stam ) domain in the N terminal portion followed by a GAT ( GGA and Tom ) domain . ^^^ Myc epitope tagged Tom1L1 showed a cytosolic distribution but was recruited to endosomes following Hrs expression . ^^^ |