| Interacting proteins: O60784 and O14964 |
Pubmed |
SVM Score :0.0 |
| The N terminal domain of the TOM 1 protein shares similarity with HGS ( hepatocyte growth factor regulated tyrosine kinase substrate ) and STAM ( signal transducing adaptor molecule ) , which are associated with vesicular trafficking at the endosome . ^^^ TOM 1 genes map to human chromosome 22q13 . 1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM . ^^^ |
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| Interacting proteins: O60784 and O14964 |
Pubmed |
SVM Score :0.0 |
| The VHS domain forms a super helix with eight alpha helices , similar to the VHS domains of TOM 1 and Hrs . ^^^ |
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| Interacting proteins: O60784 and O14964 |
Pubmed |
SVM Score :0.0 |
| These proteins have modular structures with an N terminal VHS ( VPS 27 , Hrs , and STAM ) domain followed by a GAT ( GGA and TOM 1 ) domain , a connecting hinge segment , and a C terminal GAE ( gamma adaptin ear ) domain . ^^^ |
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| Interacting proteins: O60784 and O14964 |
Pubmed |
SVM Score :0.0 |
| TOM 1 is a protein closely related to the VHS ( VPS 27 , Hrs , and STAM ) domain containing GGA family . ^^^ Neither SARA nor Hrs , two other FYVE domain proteins , interact with this region of TOM 1 . ^^^ |
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| Interacting proteins: O60784 and O14964 |
Pubmed |
SVM Score :0.0 |
| Tom1L1 ( Tom 1 like1 ) and related proteins Tom 1 ( Target of Myb 1 ) and Tom1L2 ( Tom 1 like2 ) constitute a new protein family characterized by the presence of a VHS ( Vps27p / Hrs / Stam ) domain in the N terminal portion followed by a GAT ( GGA and Tom ) domain . ^^^ |
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| Interacting proteins: O60784 and O14964 |
Pubmed |
SVM Score :0.0 |
| Lsb5p has a similar structure to the GGA [ Golgi localized , gamma ear containing , Arf ( ADP ribosylation factor ) binding ] family of proteins with an N terminal VHS [ Vps27p ( vacuolar protein sorting protein 27 ) , Hrs , Stam ] domain and a GAT ( GGA and Tom 1 ) domain . ^^^ |
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| Interacting proteins: O60784 and O14964 |
Pubmed |
SVM Score :0.0 |
| Key features of the interaction surface between the FYVE and VHS domains of Hrs , involving helices 2 and 4 of the VHS domain , are conserved in the VHS domain of Tom 1 , even though Tom 1 does not have a FYVE domain . ^^^ We also compare the structures of the VHS domains of Tom 1 and Hrs to the recently obtained structure of the ENTH domain of epsin 1 [ Hyman , J . , Chen , H . , Di Fiore , P . ^^^ |
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