| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| We show here that EPR activates two members of the ErbB family of receptor tyrosine kinases , epidermal growth factor receptor ( EGFR ) and ErbB 4 . ^^^ EPR stimulates higher levels of EGFR phosphorylation than does BTC , whereas BTC stimulates higher levels of ErbB 4 phosphorylation than does EPR . ^^^ Moreover , the EPR and BTC dose response curves show that although EGFR is more sensitive to EPR than is ErbB 4 , ErbB 4 is more sensitive to BTC than is EGFR . ^^^ Finally , ErbB 2 , which is not activated by EPR when expressed on its own , increases the sensitivity of ErbB 4 for activation by EPR . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Epiregulin ( EPR ) is a broad specificity EGF family member that activates ErbB 1 and ErbB 4 homodimers and all possible heterodimeric ErbB complexes . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Epiregulin ( EPR ) , a novel member of epidermal growth factor ( EGF ) family , is a ligand for ErbB 1 and ErbB 4 receptors . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| We characterized the expression of epidermal growth factor ( EGF ) like growth factors ( EGF , transforming growth factor alpha ( TGF alpha ) , heparin binding EGF like growth factor ( HB EGF ) , betacellulin ( BTC ) , amphiregulin ( APR ) , epiregulin ( EPR ) and neuregulin ( NRG ) 1 ) and erbB receptors ( EGF receptor ( EGFR ) , erbB2 / neu , erbB 3 and erbB 4 ) in the vaginae of mice treated either neonatally ( 0 4 day ) or as adults ( 55 59 day ) with estrogens . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| The EGF family includes EGF , transforming growth factor alpha , heparin binding EGF , amphiregulin , beta cellulin , epiregulin , and heregulins , whereas the receptor family ( the erbB genes ) consists of erbB 1 ( EGF receptor , EGF R ) , erbB 2 , erbB 3 , and erbB 4 . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Epiregulin binds to epidermal growth factor receptor and ErbB 4 and induces tyrosine phosphorylation of epidermal growth factor receptor , ErbB 2 , ErbB 3 and ErbB 4 . ^^^ Chemical cross linking experiments showed that [ 125I ] epiregulin directly bound to each of EGFR and ErbB 4 but not to ErbB 2 and ErbB 3 . ^^^ Furthermore , although epiregulin stimulated tyrosine phosphorylation of all four ErbB receptors , the main intracellular signal was mediated by ErbB 4 and / or EGFR . ^^^ Our findings indicate that ErbB 4 and EGFR are receptors for epiregulin , and suggest that EGF related ligands transduce signals for different biological responses by the hierarchical mechanism . . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| By employing a set of factor dependent cell lines engineered to express individual ErbBs or their combinations , we found that epiregulin is the broadest specificity EGF like ligand so far characterized : not only does it stimulate homodimers of both ErbB 1 and ErbB 4 , it also activates all possible heterodimeric ErbB complexes . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Each member of the group formed by BTC , heparin binding EGF ( HB EGF ) and epiregulin ( EP ) can interact with both the EGF receptor ( EGFR ) and heregulin receptors ( ErbB 3 and ErbB 4 ) , and are hence called `` bispecific ' ' ligands . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Epiregulin is a broad specificity epidermal growth factor family member that activates ErbB 1 and ErbB 4 homodimers and all possible heterodimeric ErbB complexes . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| The ErbB 4 protein plays a role as a receptor for the neuregulins , a large group of structurally related molecules and a few other epidermal growth factor ( EGF ) related polypeptides , such as heparin binding EGF , betacellulin and epiregulin . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| In this study , the effects of a putative erbB / HER ligand , gp 30 , on estrogen receptor ( ER ) concentration and activity was investigated in the estrogen receptor positive human breast cancer cells , BT 474 and MCF 7 , which express either high or low levels of erbB 2 and erbB 4 , respectively . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Patients with ER positive , HER 1 3 positive tumours had a significantly poorer survival ( p < 0 . 001 ) than those with ER positive / HER negative or HER 4 positive tumours . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| The expression of transcripts encoding the cleavable ErbB 4 isoforms associated with estrogen receptor alpha ( ER ) expression ( P < 0 . 001 ) and a high histologic grade of differentiation ( P < / = 0 . 002 ) in real time reverse transcription PCR analysis of 62 breast cancer samples . ^^^ High ErbB 4 protein expression levels , as assessed by immunohistochemistry , associated with a favorable outcome in ER positive cases from a series of 458 breast cancer patients ( P = 0 . 01 ) , whereas no association between ErbB 4 expression and survival was found among women with ER negative cancer ( P = 0 . 86 ) . ^^^ In vitro , overexpression of a cleavable ErbB 4 isoform in ER positive breast cancer cells resulted in translocation of a proteolytically released intracellular ErbB 4 receptor fragment into the nucleus , as well as , enhanced proliferation , anchorage independent growth , and estrogen response element mediated transcriptional activity . ^^^ These results suggest that the association of ErbB 4 expression with clinical outcome is dependent on the subcellular localization of ErbB 4 and that a proteinase cleavable ErbB 4 isoform promotes growth of ER positive breast cancer and enhances ER mediated gene transcription . . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Phosphorylated ERBB 2 correlated with EGFR and ERBB 2 , and inversely with oestrogen receptor ( ER ) , progesterone receptor ( PgR ) and ERBB 4 expression levels . ^^^ |
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| Interacting proteins: O14944 and Q15303 |
Pubmed |
SVM Score :0.0 |
| Six genes were over expressed ( ERBB 2 , TGFA , HB EGF , AREG , EREG and EPGN ) , 3 were under expressed ( ERBB 1 , ERBB 4 and NRG 4 ) and 2 were over or under expressed ( ERBB 3 and BTC ) . ^^^ |
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